Clinical comparison of three liver scanning agents

Abstract

The biological distributions of 99mTc-sulphur colloid, 99mTc-tin colloid and 99mTc phytate colloid were quantitatively compared in a randomised trial. All three radiopharmaceuticals gave satisfactory liver images. There is evidence to suggest that the phytate colloid significantly underestimates splenic uptake. The tin colloid was easier to dispense than the sulphur colloid and was found to be the most suitable radiopharmaceutical.

Choline treatment affects the liver reticuloendothelial system and plasma fatty acid composition in diabetic rats

“…In the present study, the effect of choline treatment on liver functions in diabetic rats was investigated using two nuclear medicine techniques: technetium‐99m‐labelled Tin (II) colloid [ 99m Tc‐Tin (II) Colloid (TIN)] and technetium‐99m‐labelled mebrofenin [bromo‐iminodiacetic acid (BrIDA) or commonly known as HIDA] hepatobiliary scintigraphy. TIN imaging has been used to study the phagocytic reticuloendothelial system (RES) in the liver, which permits an early detection of changes in liver function in the patients who do not show obvious clinical abnormalities such as liver cirrhosis (Adams et al ., ; Al‐Hussoni et al ., ; Nelson & Klopper, ; Royal et al ., ). TIN imaging is also useful for delineation of overall organ size and determinations of the presence of focal lesions and the degree of hepatocellular dysfunction in the diffuse fatty liver disease (Duman et al ., ).…”