Monographs of 99mTc Pharmaceuticals

Zolle, I.; Bremer, P. O.; Jánoki, Győző A.

doi:10.1007/978-3-540-33990-8_12

Cited by 11 publications

(30 citation statements)

References 175 publications

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“…1, are similar to the values obtained in previous studies, with a radiochemical purity of greater than 95% [6]. The radiochemical purity of 99m Tc-GSH found in this study meets the requirements for the radiopharmaceutical, which is ≥ 90% [9], and shows good reproducibility, as seen from the small standard deviation. The GSH kits prepared in a freeze-dried form (lyophilized kit) have a long shelf life, ranging from several months to years [10].…”

Section: Resultssupporting

confidence: 89%

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Physicochemical and Biological Analysis of <sup>99m</sup>Tc-Glutathione Radiopharmaceuticals

Sriyani

Zainuddin

2013

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Glutathione 99m Tc 99m Tc-glutation ( 99m Tc-GSH) radiopharmaceutical is available in the GSH lyophilized-kit in which ready to use directly after adding 99m Tc radionuclide. In nuclear medicine, 99m Tc-GSH diagnostic kit is a radiopharmaceutical commonly utilized for cancer diagnoses using imaging method. This paper described the physicochemical and biological characteristics as well as the quality of 99m Tc-GSH diagnostic kit prepared from the GSH lyophilized-kit. The radiochemical purity was determined with thin layer chromatography (TLC) method, performed on a TLC-SG stationary phase with a mobile phase of a dried acetone and 0,9% of NaCl solution. Studies on the effect of volume and radioactivity of Na 99m TcO 4 solution to the radiochemical purity of 99m Tc-GSH were carried out. The sterility of GSHlyophilized kit and toxicity of 99m Tc-GSH were also investigated. The stability test on GSH lyophilized kit and 99m Tc-GSH in several storage conditions, as well as the plasma stability of 99m Tc-GSH was performed. The analysis result showed that the GSH lyophilized-kit was sterile; the 99m Tc-GSH was non toxic with 99.54 ± 0.01% of radiochemical purity and remained stable 5 hours either at room temperature or 4 o C. The volume more than 4 mL of Na 99m TcO 4 solution on the labeling of GSH could decreased the 99m Tc-GSH radiochemical purity, while the radioactivity more than 20 mCi in 7 mL of volume extended the incubation time. In-vitro stability test of 99m Tc-GSH in plasma showed that in the two hours of storage, the radiochemical purity decreased to 51.84 ± 2.52%, and until 5 hours of storage it did not change significantly. From the result, it can be concluded that the GSH lyophilized-kit was remained stable after 13 month of storage either at room temperature or at 4 o C with 99% of 99m Tc-GSH radiochemical purity.

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Section: Resultssupporting

confidence: 89%

“…2). It can be stated that the dry GSH kit remained stable and still met the requirement of radiochemical purity being no less than 90% [5,9]. The results of the toxicity testing of 99m Tc-GSH with five white mice are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical and Biological Analysis of <sup>99m</sup>Tc-Glutathione Radiopharmaceuticals

Sriyani

Zainuddin

2013

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“…86,87 (N,S,N) donors include diaminothioether and diaminothiol ligands ( Figure 17). The diaminothioether ligands yield cationic [ 99m Tc(CO) 3 Figures 16.4 and 17). Both the (N,S,N) and (N,S,O) chelators may lead to diasteromers due to the prochirality of thioether sulfur if there is an additional chiral center.…”

Section: Tridentate Ligandsmentioning

confidence: 99%

“…The isolobal to Cp − ligand nidocarborane is prepared from dicarba-closododecaboranes followed by deprotonation. The labeling with the [ 99m Tc I (CO) 3 ] + core is performed in aqueous solution at MW/195°C for 5 minutes and yields the anionic [(CO) 3 .10). 109,110 Carboranes have similar size to the phenyl ring and demonstrate low toxicity.…”

Section: Carboranesmentioning

confidence: 99%

“…Following the radiolabeling reaction, the RCY is determined, mostly by radiochromatography ( Figure 1). 3 Suitable chromatographic systems are acetone as a mobile phase on paper chromatography or silica gel (TLC/ITLC) as stationary phases, where the unreacted pertechnetate is detected as the radioactive band that migrates to the front of the solvent. A second chromatographic system used is an aqueous solution developed on paper chromatography or (I)TLC by which the presence of colloidal TcO 2 is determined as the radioactive band that remains at the origin of the strip.…”

Section: Introductionmentioning

confidence: 99%

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Technetium‐99m radiochemistry for pharmaceutical applications

Papagiannopoulou

2017

Labelled Comp Radiopharmac

116

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Technetium-99m ( Tc) is a widely used radionuclide, and the development of Tc imaging agents continues to be in demand. This overview discusses basic principles of Tc radiopharmaceutical preparation and design and focuses on the Tc radiochemistry relevant to its pharmaceutical applications. The Tc complexes are described based on the most typical examples in each category, keeping up with the state-of-the-art in the field. In addition, the main current strategies to develop targeted Tc radiopharmaceuticals are summarized.

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