Clinical Comparison of Dexketoprofen Trometamol and Dipyrone in Postoperative Dental Pain

Bagán, José; Arranz, J. S. López; Valencia, Eduardo; Santamaría, Joseba; Eguidazu, Isabel; Horas, Manuel; Forns, Mònica; Zapata, A.; Artigas, Remei; Mauleón, David

doi:10.1002/jcph.1998.38.s1.55

Cited by 37 publications

(21 citation statements)

References 18 publications

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“…These include non-steroid anti-inflammatory drugs (NSAIDs), laser treatment, steroids and ultrasound [6–9]. However, the amount and intensity of edema, pain and trismus occurring after surgical extraction cannot be eliminated completely.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial

Özgül

Şenses

et al. 2015

Head Face Med

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BackgroundImpacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery.MethodsFifty-six patients (23 male, 33 female) who provide the inclusion criteria were selected to participate in this study. The evaluation of the facial swelling was performed by using a horizontal and vertical guide. The pain was evaluated in the postoperative period using a visual analog scale (VAS) of 100 mm.ResultsHorizontal and vertical measurements showed more swelling at the control side (without PRF) in 3th day postoperatively (p < 0.05). There were no statistically significant differences regarding pain among the groups.ConclusionAs a conclusion, PRF seems to be effectiveness on postoperative horizontal swelling after third molar surgery. PRF could be used on a routine basis after third molar extraction surgery.

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Section: Introductionmentioning

confidence: 99%

Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial

Özgül

Şenses

et al. 2015

Head Face Med

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“…Studies on the analgesic effect of metamizole sodium that have been conducted so far demonstrate that it has a similar or higher analgesic efficacy compared to classic, non-narcotic agents; it proves as efficient as powerful nonsteroid drugs such as ketoprophen and diclofenac or exerts an even stronger analgesic effect (9,10,11). Comparable studies on metamizole sodium and paracetamol administered at the same doses revealed a stronger analgesic effect and an earlier increase of pain threshold (an earlier beginning of action) when metamizole sodium was applied (12,13).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Analgesic Effect of Metamizole Sodium in Patients Operated on for Goitre

Srebrzyński

Ziółkowski

Płużańska

et al. 2008

Polish Journal of Surgery

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The aim of the study was to evaluate the analgesic effect of metamizole sodium administered intravenously during the day after surgery in patients operated on for nodular goitre -using the 11-point NAS scale (Numeric Analog Scale). Material and methods. The study was comprised of 114 patients who had undergone surgery for nontoxic: 84 (73.7%) or toxic: 30 (26.3%) nodular goitre. The goitre size, according to the WHO classification ranged between III and I° (2). I° goitre was found in 31 (27%) patients, II° goitre -in 46 (40.4%) patients and III° goitre -in 37 (32.4%) patients. The age of patients ranged between 22 and 75 years (median 53, IQR 43-61). The goitre was localized in the neck in 103 (90.4%) patients and it partially reached the superior aperture of the thorax with its lower poles in 11 (9.6%) patients. Patients with coexisting diseases such as diabetes mellitus or peripheral neuropathy were excluded from the study. Patients were randomly assigned to 4 groups. Group I included 38 subjects in whom metamizole sodium was applied at a dose of 1 g intravenously every 6 hours for a day after surgery; the first dose was administered at the moment of surgical wound closure. Group II included 37 patients in whom metamizole sodium was applied according to the above-mentioned regimen and, additionally the surgical wound was injected with 10 ml of bupivacaine 0.25%. Group III consisted of 36 patients in whom 1 g of metamizole was first administered intravenously thirty minutes before surgery and the subsequent doses were systematically repeated at time intervals of 6 hours (preemptive analgesia), avoiding buvacaine wound infiltration. Group IV included 40 patients in whom ketoprophen was administered intravenously at a dose of 0.1 g every 6 hours for a day after the procedure. Surgical wounds were not injected with buvacaine in these patients, similarly as in groups III and I. In case of severe pain patients could additionally receive morphine 1 mg on-demand. Results. Pain intensity was analyzed every 6 hours on NAS scale and pain scores ranged from 1 to 5.5. At all time points, the highest pain intensity scores were found in patients who received metamizole as monotherapy (group I) or ketoprofen (group IV), while the lowest were found in the groups where surgical wound was additionally injected with bupivacaine solution (group II) or additional metamizole dose was used before the procedure (group III). Patients from group II rated their pain intensity as slightly higher or similar to that in group III (statistically insiginficant). Similarly patients from group I had pain scores slightly higher or similar to scores reported in group IV (statistically insiginficant). Conclusions. 1. The most intense pain was observed during the first 12 hours after thyroid surgery. 2. Administration of metamizole sodium according to the regimen that was applied in groups II and III provided sufficient analgesia. 3. Infiltration of the surgical wound with buvacaine or administration of an additional dose of metamizole sodium prior ...

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“…The results however, are comparable to other analgesia studies in emergency departments that have used the VAS alone, 15 as well as other studies using dexketoprofen in a similar dose. [16][17][18][19][20] Our study showed that there was an earlier onset of analgesic efficacy with dexketoprofen compared with diclofenac, which may be attributable to more rapid absorption due to the trometamol base. Study participants given dexketoprofen were significantly more likely to have a reduction in pain score of >1 or >2 points on the scale at any intervals studied, up to one hour from oral ingestion, though this was a post hoc analysis.…”

Section: Discussionmentioning

confidence: 99%

Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury

Leman

Kapadia²,

Herington³

2003

Emergency Medicine Journal

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Objective: To assess the time of onset and difference in analgesic efficacy of oral dexketoprofen compared with oral diclofenac in patients with acute lower limb injury. Design: A prospective, double blind, randomised controlled trial. Interventions: Patients who fitted the study criteria were given either 25 mg oral dexketoprofen trometamol or 50 mg sodium diclofenac immediately after triage; baseline and 15 minute pain scores were then recorded for one hour. Results: 122 patients were studied (diclofenac = 57 and dexketoprofen = 65). There were no significant differences in age, sex, type of injury, or baseline pain scores between the two groups. The differences in group mean pain scores between diclofenac and dexketoprofen at 15, 30, 45, and 60 minutes were; 0.53 (95% confidence intervals 20.03 to 1.09), 0.70 (0.16 to 1.24), 0.89 (0.32 to 1.47), and 0.83 (0.21 to 1.45). Odds ratios for a decrease in pain score of at least 1 from baseline (on the 11 point scale) when given dexketoprofen rather than diclofenac at 15, 30, 45, and 60 minutes were; 2.66 (1.19 to 5.98), 3.52 (1.60 to 7.73), 4.48 (1.72 to 11.65), and 5.54 (1.90 to 16.15). Corresponding odds ratios for a decrease in pain score of >2 were; 6.88 (1.48 to 32.0), 3.79 (1.59 to 9.01), 5.19 (2.29 to 11.78), and 5.87 (2.68 to 12.88). Conclusions: Dexketoprofen trometamol is an effective and rapidly acting analgesic for the treatment of acute musculoskeletal injuries. D exketoprofen trometamol is the water soluble salt of the S-isomer of the racemic non-steroidal anti-inflammatory (NSAID) drug ketoprofen.1 S-isomers rotate polarised light to the right, while R isomers rotate it to the left. Dexketoprofen acts by inhibition of cyclooxygenase, thus diminishing prostaglandin synthesis. It has been shown that the stereo-isomer of ketoprofen is about 3000 times more potent than the R-isomer at doing this. 2 3 Additionally in vitro studies have shown greater COX-1 inhibition with this Sisomer of ketoprofen, compared with other racemic NSAIDs. 4 The trometamol salt form of dexketoprofen was formulated to improve the pharmacokinetics of the orally administered drug. The maximum concentration is greater and the time to it less, with the trometamol salt compared with the free acid form of dexketoprofen. This study was designed to assess whether this new form of NSAID using enantiomer selectivity would perform more effectively in the ED setting than a standard NSAID. The criteria for effectiveness were time of onset of effect and size of effect. Diclofenac was chosen as the comparator as it is the most widely used NSAID in England.

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Clinical Comparison of Dexketoprofen Trometamol and Dipyrone in Postoperative Dental Pain

Cited by 37 publications

References 18 publications

Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial

Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial

Analysis of the Analgesic Effect of Metamizole Sodium in Patients Operated on for Goitre

Randomised controlled trial of the onset of analgesic efficacy of dexketoprofen and diclofenac in lower limb injury

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