Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial

Abstract

BackgroundImpacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery.MethodsFifty-six patients (23 male, 33 female) who provide the inclusion criteria were selected to participate in this study. The evaluation of the facial swelling was performed by using a horizontal and vertical guide. The pain was evaluated in the postoperative period using a visual analog scale (VAS) of 100 mm.ResultsHorizontal and vertical measurements showed more swelling at the control side (without PRF) in 3th day postoperatively (p < 0.05). There were no statistically significant differences regarding pain among the groups.ConclusionAs a conclusion, PRF seems to be effectiveness on postoperative horizontal swelling after third molar surgery. PRF could be used on a routine basis after third molar extraction surgery.

Trombositten zengin fibrinin gömülü yirmi yaş dişi cerrahisi sonrası postoperatif komplikasyonların azaltılmasına etkisi: prospektif, randomize kontrollü klinik araştırma

“…In the present study, we did not find significant differences between the two groups regarding pain, swelling, and trismus. Our findings are consistent with the findings of two previous studies 10,13 but different from the findings of one study. 4 Different results have been presented in the literature on the effects of PRF on postoperative pain, swelling, and trismus after third molar surgery.…”

“…4 Different results have been presented in the literature on the effects of PRF on postoperative pain, swelling, and trismus after third molar surgery. 4,10,13 The disparities may be related to the use of subjective data in these studies. 3,4,13 In the aforementioned studies, postoperative antibiotics were prescribed.…”

“…They reported that the application of PRF decreased pain, swelling, and trismus on the first postoperative day. Ozgul et al 10 also investigated the efficacy of PRF in the reduction of pain and swelling after impacted third molar surgery, and they reported more swelling in the control group on the third postoperative day; however, there was no significant difference regarding pain between the groups. Singh et al 13 also indicated that the use of PRF did not reduce postoperative pain.…”

“…[7][8][9] However, there are only few studies regarding the effect of PRF on complications following third molar surgery. 4,10 The aim of this study was to evaluate the effect of PRF on postoperative pain, swelling, and trismus following impacted third molar surgery. Furthermore, patient's quality of life (QOL) was assessed postoperatively.…”

The use of platelet‐rich fibrin to enhance the outcomes of implant therapy: A systematic review

“…There are numerous studies assessing PRF effect on pain with mandibular third molar extraction (Al‐Hamed et al., 2017). However, only few studies used a blinded protocol (Afat, Akdogan, & Gonul, 2017; Ozgul et al., 2015). In consequence, patient‐reported outcomes such as pain must be interpreted with caution.…”