Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation

Ye, Guangming; Pan, Zhenyu; Pan, Yunbao; Deng, Qiaoling; Chen, Liangjun; Jin, Li; Li, Yirong; Wang, Xinghuan

doi:10.1016/j.jinf.2020.03.001

Cited by 335 publications

(381 citation statements)

References 7 publications

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“…To date, it is not proven that a patient that recovered from a previous infection to COVID-19 developed a complete and lasting immunity to the disease. In fact, reactivation of the disease [34] or even reinfection have been reported [35]. Our suggested preventive measures should be followed until herd immunity is achieved and the following patient categories are properly identified: * People aged 70 or older, people under 70 with an underlying health condition (chronic respiratory diseases, chronic heart disease, chronic kidney disease, chronic liver disease, chronic neurological conditions, diabetes, problems with spleen, a weakened immune system due to conditions such as HIV and AIDS or medicines, a body mass index (BMI) of 40 or above), pregnant women [36].…”

Section: Covid-19 Prevention In Dentistrymentioning

confidence: 99%

Dentistry during the COVID-19 Epidemic: An Italian Workflow for the Management of Dental Practice

Peditto

Scapellato

Marcianó

et al. 2020

IJERPH

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Section: Covid-19 Prevention In Dentistrymentioning

confidence: 99%

Dentistry during the COVID-19 Epidemic: An Italian Workflow for the Management of Dental Practice

Peditto

Scapellato

Marcianó

et al. 2020

IJERPH

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“…A recently identified clinical phenomenon is reactivation of COVID‐19 infection in a subset of patients following recovery from initial disease. Although it has not yet been widely reported in the peer‐review medical literature, a report by Ye et al 8 identified reactivation in five patients from a cohort of 55 patients from China. Notably, influenza and H7 avian influenza virus were excluded by additional testing, but repeat testing for COVID‐19 does not appear to have been performed.…”

Section: Introduction: Epidemiology and Clinical Features Of The 2019mentioning

confidence: 99%

COVID‐19 and the clinical hematology laboratory

Frater

Zini

D’Onofrio

et al. 2020

Int J Lab Hematology

250

275

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The ongoing COVID-19 pandemic originated in Wuhan, Hubei Province, China in December 2019. The etiologic agent is a novel coronavirus of presumed zoonotic origin with structural similarity to the viruses responsible for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Like SARS and MERS, COVID-19 infection manifests most frequently with lower respiratory symptoms. A minority of patients progress to acute respiratory distress syndrome/ diffuse alveolar damage. In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. The purpose of this review is to 1) provide background context about the origins and course of the pandemic 2) discuss the laboratory's role in the diagnosis of COVID-19 infection 3) summarize the current state of biomarker analysis in COVID-19 infection, with an emphasis on markers derived from the hematology laboratory 4) comment on the impact Accepted Article of COVID-19 on hematology laboratory safety, and 5) describe the impact the pandemic has had on organized national and international educational activities worldwide.

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“…Unfortunately, though, SARS-CoV-2 reactivation and clinical deterioration have been reported in patients after hospital discharge 9 . Besides, some recovered patients can still excrete SARS-CoV-2, as demonstrated by the presence of viral nucleic acids in throat specimens 10 .…”

Section: Introductionmentioning

confidence: 99%

Virologic and clinical characteristics for prognosis of severe COVID-19: a retrospective observational study in Wuhan, China

Song

et al. 2020

Preprint

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Background:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has progressed to a pandemic associated with substantial morbidity and mortality. The WHO and the United States Center for Disease Control and Prevention (CDC) have issued interim clinical guidance for management of patients with confirmed coronavirus disease (COVID-19), but there is limited data on the virologic and clinical characteristics for prognosis of severe COVID-19. Methods:A total of 50 patients with severe COVID-19 were divided into good and poor recovery groups. The dynamic viral shedding and serological characteristics of SARS-CoV-2 were explored. The risk factors associated with poor recovery and lung lesion resolutions were identified. In addition, the potential relationships among the viral shedding, the pro-inflammatory response, and lung lesion evolutions were characterized. Results:A total of 58% of the patients had poor recovery and were more likely to have a prolonged interval of viral shedding. The longest viral shedding was 57 days after symptom onset. Older age, hyperlipemia, hypoproteinemia, corticosteroid therapy, consolidation on chest computed-tomography (CT), and prolonged SARS-CoV-2 IgM positive were all associated with poor recovery. Additionally, the odds of impaired lung lesion resolutions were higher in patients with hypoproteinemia, hyperlipemia, and elevated levels of IL-4 and ferritin. Finally, viral shedding and proinflammatory responses were closely correlated with lung lesion evolutions on chest CT. : medRxiv preprint ConclusionsPatients with severe COVID-19 have prolonged SARS-CoV-2 infection and delayed intermittent viral shedding. Older age, hyperlipemia, hypoproteinemia, corticosteroid usage, and prolonged SARS-CoV-2 IgM positive might be utilized as predicative factors for the patients with poor recovery.

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Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation

Cited by 335 publications

References 7 publications

Dentistry during the COVID-19 Epidemic: An Italian Workflow for the Management of Dental Practice

Dentistry during the COVID-19 Epidemic: An Italian Workflow for the Management of Dental Practice

COVID‐19 and the clinical hematology laboratory

Virologic and clinical characteristics for prognosis of severe COVID-19: a retrospective observational study in Wuhan, China

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