Clinical Characteristics of Patients with COVID-19 in Saudi Arabia - A Single Center Experience

Saleemi, Sarfraz; Mohammed, Ahmed; Reem, Almaghrabi; Fahad, Alrabiah; Faisal, Albaiz; Rayan, Alfadda; Edathodu, Jameela

doi:10.36959/719/568

Cited by 3 publications

(2 citation statements)

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“…The predominant symptoms were fever, cough, and dyspnea. Our cohort showed a higher percentage of dyspnea (65%) compared to other reports from KSA (27%) (Sarfraz et al, 2020), Turkey (27.8%) (Altunok et al, 2020), and China (6.9%) (Tian et al, 2020). Regarding the 160 patients admitted to the ICU, the fatality rate (CFR) was 47.6%.…”

Section: Discussioncontrasting

confidence: 53%

Clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak of the pandemic

Barry

Althabit

Akkielah

et al. 2021

International Journal of Infectious Diseases

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Objective To describe the clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak months of the pandemic. Design A single-center case series of hospitalized individuals with confirmed SARS-CoV-2 infections in King Saud University Medical City (KSUMC), an academic tertiary care hospital in Riyadh, KSA. Clinical and biochemical markers were documented. Risks for ventilatory support, intensive care unit (ICU) admission, and death are presented. Results Out of 12,688 individuals tested for SARS-CoV-2 by RT-PCR, 2,683 (21%) were positive for COVID-19. Of the latter, 605 (22%) patients required hospitalization with a median age of 55 years, and 368 (61%) were male. The most common comorbidities were hypertension (43%) and diabetes (42%). Most patients presented with fever (66%), dyspnea (65%), cough (61%), elevated IL-6 (93.5%), D-dimer (90.1%), CRP (86.1%), and lymphopenia (41.7%). No MERS-CoV co-infection was detected. Overall 91 patients (15%) died, risk factors associated with mortality were age of 65 years or older OR 2.29 [CI 1.43–3.67], presence of two or more comorbidities OR 3.17 [CI 2.00–5.02], symptoms duration of seven days or less OR 3.189 [CI (1.64 – 6.19]) lymphopenia OR 3.388 [CI 2.10–5.44], high CRP OR 2.85 [CI 1.1–7.32], high AST OR 2.95 [CI 1.77–4.90], high creatinine OR 3.71 [CI 2.30–5.99], and high troponin-I OR 2.84 [CI 1.33–6.05]. Conclusion There is a significant increase in severe cases of COVID-19. Mortality was associated with older age, shorter symptom duration, high CRP, low lymphocyte count, and end-organ damage.

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Section: Discussioncontrasting

confidence: 53%

Clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak of the pandemic

Barry

Althabit

Akkielah

et al. 2021

International Journal of Infectious Diseases

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“…Approximately 77% of our patients were younger than 65 years. The finding that younger adults represent the majority of hospitalized patients with COVID-19 was also found by another local study from a center in the capital of Saudi Arabia, where 66% of patients were younger than 60 years [ 17 ]. The median age of our patients was 53 years, which is similar to a systemic review of six studies conducted in China, where the median age was 55.5 years [ 18 ].…”

Section: Discussionsupporting

confidence: 58%

Factors associated with poor outcomes among hospitalized patients with COVID-19: Experience from a MERS-CoV referral hospital

Barry¹,

Alotaibi²,

Almohaya³

et al. 2021

Journal of Infection and Public Health

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Background Coronavirus disease 2019 (COVID-19) has resulted in millions of deaths, including more than 6000 deaths in the Kingdom of Saudi Arabia (KSA). Identifying key predictors of intensive care unit (ICU) admission and mortality among infected cases would help in identifying individuals at risk to optimize their care. We aimed to determine factors of poor outcomes in hospitalized patients with COVID-19 in a large academic hospital in Riyadh, KSA that serves as a Middle East Respiratory Syndrome coronavirus (MERS-CoV) referral center. Methods This is a single-center retrospective cohort study of hospitalized patients between March 15 and August 31, 2020. The study was conducted at King Saud University Medical City (KSUMC). COVID-19 infection was confirmed using real-time reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-COV-2. Demographic data, clinical characteristics, laboratory, radiological features, and length of hospital stay were obtained. Poor outcomes were, admission to ICU, need for invasive mechanical ventilation (IMV), and in-hospital all-cause mortality. Results Out of 16,947 individuals tested in KSUMC, 3,480 (20.5%) tested positive for SARS-CoV-2 and of those 743 patients (21%) were hospitalized. There were 62% males, 77% were younger than 65 years. Of all cases, 204 patients (28%) required ICU admission, 104 (14%) required IMV, and 117 (16%) died in hospital. In bivariate analysis, multiple factors were associated with mortality among COVID-19 patients. Further multivariate analysis revealed the following factors were associated with mortality: respiratory rate more than 24/min and systolic blood pressure < 90 mmHg in the first 24 hours of presentation, lymphocyte count <1 × 10 9 /L and aspartate transaminase level > 37 units/L in the first 48 hours of presentation, while a RT-PCR cycle threshold (Ct) value ≤24 was a predictor for IMV. Conclusion Variable factors were identified as predictors of different outcomes among COVID-19 patients. The only predictor of IMV was a low initial Ct values of SARS-CoV-2 PCR. The presence of tachypnea, hypotension, lymphopenia, and elevated AST in the first 48 hours of presentation were independently associated with mortality. This study provides possible independent predictors of mortality and invasive mechanical ventilation. The data may be helpful in the early identification of high-risk COVID-19 patients in areas endemic with MERS-CoV.

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Features and Outcomes of Confirmed COVID-19 Patients Presenting to the Emergency Department

Bokhary¹,

Bokhary²,

Seadawi³

et al. 2022

Cureus

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Clinical Characteristics of Patients with COVID-19 in Saudi Arabia - A Single Center Experience

Cited by 3 publications

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Clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak of the pandemic

Clinical characteristics and outcomes of hospitalized COVID-19 patients in a MERS-CoV referral hospital during the peak of the pandemic

Factors associated with poor outcomes among hospitalized patients with COVID-19: Experience from a MERS-CoV referral hospital

Features and Outcomes of Confirmed COVID-19 Patients Presenting to the Emergency Department

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