Clinical characteristics of patients with premature acute coronary syndrome and adverse cardiovascular events after PCI

Abstract

Few studies have compared the clinical manifestations of patients with premature acute coronary syndrome (ACS) and late-onset ACS as well as the adverse cardiovascular events following percutaneous coronary intervention (PCI). To investigate the clinicopathological characteristics of patients with premature ACS and adverse cardiovascular events following PCI, a total of 726 patients with ACS undergoing PCI were divided into two groups: A premature ACS group and a late-onset ACS group. Following discharge, all patients were followed-up for an average of 23.5±5.3 months. Clinical characteristics, Gensini scores, vascular lesions and adverse cardiovascular events were compared between the two groups. There were no significant differences in smoking, diabetes, ACS composition ratio, baseline treatment of coronary heart disease, high-density lipoprotein level and C-reactive protein levels between the two groups. Sex and hypertriglyceridemia were determined to be independent risk factors of premature ACS, while age, hypertension and a high Gensini score were independent risk factors for adverse cardiovascular events in patients with ACS following PCI. Furthermore, the prevalence of premature ACS was significantly higher in females. Although serum levels of fasting blood glucose, total cholesterol, triglycerides and low-density lipoprotein were also significantly higher in patients with premature ACS compared with patients with late-onset ACS, patients with premature ACS exhibited fewer vascular lesions compared with patients with late-onset ACS. Furthermore, the incidence of adverse cardiovascular events in patients with ACS following PCI did not differ significantly between premature and late-onset ACS groups. Taken together, these results suggest that female patients should be closely observed for early risk factors of premature ACS to prevent and reduce the occurrence of adverse cardiovascular events in patients with ACS following PCI.

Prevalence of Cardiovascular Risk Factors and Heterozygous Familial Hypercholesterolemia in Premature Atherosclerotic Patients Presenting with Acute Coronary Syndrome

“…Regarding to the age of the patients included in our study, the mean age of was 47.09 ± 6.25 years, there were 75 patients with age <50 y and 25 patients with age ≥50 y. This was concordant with Shi et al, in which the mean age of patients presented with premature ACS was 52.7 ± 7.6 years [7].…”

Risk Factor Analysis and Construction of a Prognostic Model after Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion

“…A large number of studies have discovered that patients with coronary heart disease are prone to adverse cardiovascular events within 1 year after PCI, which greatly affects the prognosis of patients [ 10 , 11 ]. And the occurrence of adverse cardiovascular events is closely associated with the risk factors of coronary heart disease in addition to their own dietary habits and living habits [ 12 ].…”

Correlation between monocyte to high-density lipoprotein ratio and major adverse cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention

“…The lipid metabolism disorder in ACS patients is triggered by the joint action of multiple effector cells and cytokines. 10 In addition, macrophages transformed from monocytes in serum are the initiating cells of plaque formation in ACS. 11 Macrophages phagocytize LDLC and its apolipoprotein ApoB lipid particles and deposits on the vascular endothelium.…”