Clinical Characteristics of Myositis Associated with Graft-Versus-Host Disease

Limaye, Sandhya; Limaye, Vidya

doi:10.1007/s11926-021-00996-x

Cited by 10 publications

(2 citation statements)

References 57 publications

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“…Myositis is characterized by proximal muscle weakness and is often associated with chronic GVHD. It can occur in 2-3% of HCT recipients (Limaye and Limaye 2021). Previous exposure to immune checkpoint inhibitor may increase the risk of developing myositis.…”

Section: Myositismentioning

confidence: 99%

Neurological Complications

Duléry,

Schmidt-Hieber,

Sharrack

2024

The EBMT Handbook

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Neurological complications of allogeneic hematopoietic cell transplantation are frequent and often highly challenging to manage. These complications can stem from various causes, including neurotoxic drugs, infectious pathogens, cerebrovascular illness, metabolic encephalopathy, hematological disease relapse, immune-mediated disorders, thrombotic microangiopathy, and post-transplant lymphoproliferative disorder. While many of these complications are transient, a substantial subset is potentially fatal. Therefore, prompt diagnosis and treatment, guided by a neurologist, can be crucial in reducing the risks of irreversible complications, impairment of the quality of life, and transplantation-related mortality.

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Section: Myositismentioning

confidence: 99%

Neurological Complications

Duléry,

Schmidt-Hieber,

Sharrack

2024

The EBMT Handbook

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“…Chronic GVHD occurring in allogeneic hemopoietic stem cell transplantation is a multisystem disorder of immune dysregulation. The muscle may become a target of the immune response, and myositis is a well known manifestation of the disorder [30]. IMNM may occasionally be the pathological substrate in these patients, although is difficult to distinguish between GVHD-associated myositis, which usually appears several months after transplantation and is accompanied by involvement of other organs (e.g.…”

Section: Chronic Graft-versus-host Diseasementioning

confidence: 99%

Differential diagnosis of necrotizing myopathy

Selva-O’Callaghan¹,

Trallero-Araguás²,

Milisenda

et al. 2021

Current Opinion in Rheumatology

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Purpose of reviewNecrotizing myopathy is a broad term. It includes patients with the recently described immune-mediated necrotizing myopathies (IMNM) who have specific antibodies, such as anti-hydroxy-3-methylglutaryl-CoA reductase or anti-signal recognition particle, seronegative phenotypes that can be associated with cancer, and other types of myositis and connective tissue diseases involving necrotic muscle fibers as a characteristic pathologic feature. Necrotizing myopathies that are not immune-mediated, such as those caused by drugs, dystrophies, infections, or even hypothyroidism are also included. The purpose of this review is to address the differential diagnosis of these disorders.Recent findingsNew IMNM have been described over the last few years, some of them related with checkpoint inhibitors, drugs that are being increasingly used in cancer treatment. Necrotizing myopathy has also been reported in association with specific phenotypes and autoantibodies (e.g. anti-Mi2 dermatomyositis, antisynthetase syndrome, and myositis associated with antimitochondrial antibodies). Rarer cases associated with graft-versus-host disease and severe acute respiratory syndrome coronavirus 2 infection are also emerging.SummaryDifferentiation between patients with IMNM and those without the superimposed autoimmune phenomena helps clinicians determine the best individualized approach to use and the appropriate immunosuppressive therapy, whenever needed.

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Neurologic Considerations in Critically Ill Hematopoietic Stem Cell Transplantation Patients

Ume

Dhar

2023

Pulmonary and Critical Care Considerations of Hematopoietic Stem Cell Transplantation

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Clinical Characteristics of Myositis Associated with Graft-Versus-Host Disease

Cited by 10 publications

References 57 publications

Neurological Complications

Neurological Complications

Differential diagnosis of necrotizing myopathy

Neurologic Considerations in Critically Ill Hematopoietic Stem Cell Transplantation Patients

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