Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children

Hsing, Tzu-Yun; Lu, Chun‐Yi; Chang, Luan‐Yin; Liu, Yun-Chung; Lin, Hsiao-Chi; Chen, Li-Lun; Liu, Yucheng; Yen, Ting‐Yu; Chen, Jong-Min; Lee, Ping–Ing; Huang, Li‐Min; Lai, Feipei

doi:10.1016/j.jfma.2021.07.012

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…Previous studies demonstrated a link between bacterial coinfection and worse outcomes in viral respiratory tract infection. 19 Among the various bacteria coinfections, noninvasive S. aureus infection was an independent risk factor. The role of noninvasive bacterial isolates is intriguing and it seemed specifically apply to S. aureus , which was at a high rate of antibiotic resistance.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children

Ma,

Lin,

Liu

et al. 2024

Pediatric Infectious Disease Journal

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Background: Respiratory syncytial virus (RSV) is a common cause of bronchiolitis and pneumonia in infants and young children. Starting in December 2010, RSV monoclonal antibody (RSV mAb) was endorsed by Taiwan National Health Insurance and given to children with prematurity and/or congenital heart diseases, which are considered high-risk factors for severe RSV diseases. Investigating other important contributing risk factors is warranted. Methods: We conducted a cohort study at National Taiwan University Hospital to determine the rate of severe outcomes among children hospitalized due to RSV infection from 2008 to 2018. Adjusted for age, sex and birth cohorts born before and after RSV mAb endorsement, we identified risk factors for severe RSV infection, defined as the requirement of invasive ventilator support. Results: There were 1985 admissions due to RSV infections. Among them, 66 patients (3.3%) had severe RSV infection. The proportion of severe RSV infections decreased significantly after RSV mAb endorsement. Multivariable analysis revealed that age <1.5 months and cardiovascular and congenital/genetic diseases were high-risk underlying conditions. In addition, bacterial coinfections, elevated creatinine levels and initial abnormal chest radiograph findings posed warning signs for severe RSV infection. Conclusions: Children younger than 1.5 months of age with cardiovascular or congenital/genetic diseases were predisposed to severe RSV infection and might benefit from RSV mAb prophylaxis.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children

Ma,

Lin,

Liu

et al. 2024

Pediatric Infectious Disease Journal

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“…Research shows that children are in the stage of growth and development, and their special respiratory anatomical structure, physiological characteristics, and immune system are easy to cause pneumonia, which has become one of the most common diseases in the process of children’s growth. − Strengthening the investigation of the causes of pneumonia in children is conducive to disease prevention and treatment and improving the treatment effect. , There are many causes for pediatric pneumonia, among which, pediatric pneumonia is considered as the most important high-risk factor for pediatric pneumonia progression. The present data first suggest that Avenanthramide C protects pediatric pneumonia and reduced inflammation in the mice model.…”

Section: Discussionmentioning

confidence: 99%

Avenanthramide C from Oats Protects Pyroptosis through Dependent ROS-Induced Mitochondrial Damage by PI3K Ubiquitination and Phosphorylation in Pediatric Pneumonia

Shen

Zhang

et al. 2022

J. Agric. Food Chem.

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Oat containing rich β-glucan, polyphenols, flavonoids, saponins, alkaloids, and other substances shows good biological activities. Therefore, the present study aimed to uncover the possible mechanism and therapeutic effect of Avenanthramide C in lessening inflammatory responses in pediatric pneumonia. Pediatric pneumonia was induced by liposaccharide (LPS) for vivo model and vitro model. Macrophage was performed to determine the mechanism and effects of Avenanthramide C in pediatric pneumonia. NLRP3 activity participated in the effects of Avenanthramide C in pediatric pneumonia. Avenanthramide C induced p-PI3K and p-Akt expressions and reduced ubiquitination of PI3K expression in pediatric pneumonia. On the other hand, Avenanthramide C integrated serine at 821 sites of the PI3K protein function. Avenanthramide C reduced ROS (reactive oxygen species)-induced mitochondrial damage by PI3K/AKT function in a model of pediatric pneumonia. Avenanthramide C protects pyroptosis in a model of pediatric pneumonia by PI3K/AKT/Nrf2/ROS signaling. Taken together, our results demonstrated that Avenanthramide C protects pyroptosis through dependent ROS-induced mitochondrial damage by PI3K ubiquitination and phosphorylation in a model of pediatric pneumonia, suggesting its potential use for the treatment of pediatric pneumonia and other inflammatory diseases.

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“…autorių atliktame tyrime, nagrinėjant 2017-2019 metų vaikų gripo duomenis, pastebėta, kad gripu sergančių vaikų CRB kiekis buvo mažesnis, lyginant su gripo neigiama grupe [11]. Keletas kitų atliktų tyrimų pabrėžia, kad padidėjusi CRB koncentracija yra dažniau susijusi su sunkiu A tipo gripu arba su antrine bakterine infekcija [18]. Vaikų su bakterine infekcija CRB yra aukštesnis, nei vaikų su A tipo gripu, o pacientų su A tipo gripu CRB aukštesnis, nei sveikų vaikų [19].…”

Section: Klinikinių Požymių Ir Laboratorinių Rodiklių Pokyčių Reikšmė...unclassified

Klinikinių Požymių Ir Laboratorinių Rodiklių Pokyčių Reikšmė Vaikų Gripo Diagnostikai

Vaikšnoraitė

2023

Health Sciences

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Nors šiuo metu gripo greitieji testai (antigeno nustatymo testas, greitas PGR testas) ir toliau išlieka auksiniu standartu gripo diagnostikoje, ankstyvas klinikinių požymių bei labaratorinių kraujo tyrimų rezultatų vertinimas galėtų padėti sveikatos priežiūros specialistams greičiau įtarti gripo infekciją. Atliktos mokslinės literatūros apžvalgos rezultatai parodė, kad vaikų gripui, labiau nei kitoms ūminėms respiracinėms infekcijoms, būdinga sloga, galvos ir raumenų skausmai. Svarbu atkreipti dėmesį ir į gripui mažiau specifinius simptomus, tokius kaip vėmimas, viduriavimas, pilvo skausmas, kurie labiau būdingi vaikams, nei suaugusiems. Vertinant gripu sergančių vaikų labaratorinius kraujo tyrimus, sumažėjęs arba normalus leukocitų kiekis, limfopenija, trombocitopenija, mažesnis CRB kiekis yra būdingesni gripui, nei kitoms ūminėms respiracinėms infekcijoms. Literatūroje retai minami LYM*PLT, LMS ir NLS rodiklių pokyčiai gali padėti anksti įtarti gripo infekciją ir diferencijuoti ją nuo kitų susirgimų.

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Clinical characteristics of influenza with or without Streptococcus pneumoniae co-infection in children

Cited by 11 publications

References 29 publications

Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children

Risk Factors for Severe Respiratory Syncytial Virus Infection in Hospitalized Children

Avenanthramide C from Oats Protects Pyroptosis through Dependent ROS-Induced Mitochondrial Damage by PI3K Ubiquitination and Phosphorylation in Pediatric Pneumonia

Klinikinių Požymių Ir Laboratorinių Rodiklių Pokyčių Reikšmė Vaikų Gripo Diagnostikai

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