Clinical characteristics of coronavirus disease 2019 in Gansu province, China

Abstract

Background: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has outbreak in the world. Little is known about the clinical characteristics of patients with SARS-CoV-2 infection in the high-altitude region of China. We reported the clinical characteristics of patients with coronavirus disease 2019 in Gansu province, China.Methods: In this retrospective study, patients with laboratory-confirmed SARS-CoV-2 infection were consecutively enrolled from January 21, 2020 to February 11, 2020. The information on the epidemiological, clinical characteristics, laboratory tests, radiological features on admission, treatment and outcome were obtained with the final follow-up of March 13, 2020. On the basis of the median length of hospital stay, patients were further analyzed in two groups (long-vs. short-hospital stay).Results: Of the 86 patients of COVID-19 in 11 cities of Gansu Province, the median hospital stay was 14.0 days (interquartile rang, 11.0-19.0 days). In the overall cohort, the median age was 41.0 years (interquartile rang, 31.0-54.3 years), and 48 (55.8%) patients were female. Forty (46.5%) had a history of exposure to epidemic regions, but none exposed to the Huanan seafood market in Wuhan. Common symptoms included fever (41, 47.7%), and cough (38, 44.2%). On admission, 30 (34.9%) and 58 (67.4%) patients had leukopenia and lymphopenia. According to chest CT scans, 53 (66.3%) of 80 patients showed bilateral pneumonia, and 19 (23.8%) of 80 patients showed unilateral pneumonia. Of the 15 asymptomatic cases, 10 (66.6%) cases were found CT findings of pneumonia. Besides, there were 65 (75.6%) patients with mild and moderate type of COVID-19. All 86 patients received antiviral and traditional Chinese medicine therapy, 53 (61.6%) received antibacterial therapy, and 3 (3.5%) patients received invasive ventilator mechanical ventilation. The proportion of patients received antibiotic treatment in long-hospital stay group was significantly higher than that in the short-hospital stay group (P=0.045). As of March 13, 2020, 84 (97.7%) patients were discharged, and two (2.3%) cases died.Conclusions: In the Gansu province cohort of 86 patients of COVID-19, most patients were with mild or moderate type, and most asymptomatic cases showed CT imaging findings of SARS-CoV-2 related pneumonia.

SARS‐CoV‐2 and hypertension

“…As a sign of worse disease progression, patients show leukopenia and lymphopenia (Guan et al, 2020; Yue et al, 2020). Chest computed tomography scans (CTs) of some patients with SARS‐CoV‐2 infection show bilateral pneumonia (Du et al, 2020; Guan et al, 2020; Wang, Yin, et al, 2020; Yue et al, 2020). Pneumonia is a common clinical manifestation of the COVID‐19 and can lead to acute respiratory distress syndrome (ARDS).…”

Dengue Myocarditis Complicated by COVID-19: A Case Report on Dual Viral Infection

“…The characteristics of both the viruses in terms of epidemiological and clinical presentation are shown in Table 2 [ 8 ]. A study by Yue et al showed a huge overlap between clinical spectrums of both diseases, with fever and headache being the most common symptoms in both [ 2 ]. Our patient had presented with fever and bleeding manifestation with no respiratory and cardiovascular symptoms at presentation or no exposure to COVID-19, and hence the possibility for a tropical illness was significant.…”

“…Novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a lethal global pandemic [ 1 ]. It exhibits varied clinical manifestations, potentially affecting every organ system, although fever remains a common symptom [ 2 ]. In India, dengue virus (DENV) infection, transmitted by Aedes aegypti , is one of the most common causes of acute undifferentiated febrile illness (AUFI) with endemicity, usually during the monsoon and post-monsoon seasons.…”

From advanced disease to transplantation: an overview of the liver at the time of COVID-19 pandemic

“…Available data from Chinese studies indicate that chronic liver diseases can be diagnosed in 2–11% of subjects with COVID-19 [ 11 – 17 ]. In Italy, Grasselli et al [ 18 ] reported that among 1591 patients in intensive care units in the Lombardy region, 3% had a history of liver disease.…”