Clinical characteristics of childhood cancer in emergency room in a tertiary hospital in Pakistan

Jawaid, Amna; Arif, Khubaib; Brown, Nick; Fadoo, Zehra

doi:10.5847/wjem.j.1920-8642.2016.04.011

Cited by 4 publications

(3 citation statements)

References 15 publications

(13 reference statements)

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“…Worldwide it is estimated that 1,60,000 new cases are diagnosed every year [1]. Statistically, the most common childhood malignancies are childhood leukemia, CNS tumor and lymphomas, while childhood leukemia is one of frequent malignancy (4-40/100000 children) of childhood in world as well in Pakistan [2]. The actual incidence of childhood leukemia per year is not known because nonexistence of national malignancy registry in Pakistan and Afghanistan [3].…”

Section: Introductionmentioning

confidence: 99%

Childhood Leukemias in Khyber Pakhtunkhwa and Afghan Children Visiting to Hayatabad Medical Complex Hospital

Khan¹,

Mir²,

Khattak³

et al. 2017

Can Res

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Section: Introductionmentioning

confidence: 99%

Childhood Leukemias in Khyber Pakhtunkhwa and Afghan Children Visiting to Hayatabad Medical Complex Hospital

Khan¹,

Mir²,

Khattak³

et al. 2017

Can Res

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“…In another study conducted at The Children's Hospital Lahore, Faizan et al (16) (2018) reported similar higher proportion of males (m:f; 1.7:1) and under 5 years age group (59.0%) among children presenting with abdominal mass. In a similar study conducted at Aga Khan University Hospital, Karachi, Jawaid et al (17) predominance among such children with male to female ratio of 1.5:1. Our results also match with those of Indian studies where Gupta et al (18) (2018) and Mohan et al (19) (2017) observed comparable higher proportion of under 5 year age group and reported it to be 58.0% and 59.9% respectively while Khan et al (20) (2015) and Sharma et al (21) (2014) reported similar male predominance with male to female ratio of 1.9:1 and 2:1 respectively among such children.…”

Section: Discussionmentioning

confidence: 80%

Accuracy of MRI in the Differential Diagnosis of Wilms Tumor

Ashraf¹,

Anjum²,

Tahir³

et al. 2021

PJMHS

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Background & Objective: Renal tumors are a common finding in diagnostic imaging; these lesions usually are solid or cystic, benign or malignant, and the correct diagnosis may be difficult. The current study aims at to determine the diagnostic accuracy of magnetic resonance imaging for the diagnosis of Wilms tumor taking histopathology as gold standard. Methodology: This cross-sectional study was carried at the Department of Radiology, The Children’s Hospital & Institute of Child Health Lahore over 6 months from March 2019 to September 2019. The study involved 125 children of both genders aged between 2 years to 14 years presenting with a neoplastic mass in the retroperitoneum on ultrasound abdomen during initial workup. These children were assessed on MRI for the diagnosis of Wilms tumor. Later the diagnosis was confirmed on histopathology which was taken as gold standard and the diagnosis of MRI was judged accordingly as true/false and positive/negative. A written informed consent was obtained from every patient. Results: The mean age of the children was 5.8±3.9 years having a male predominance with male to female ratio of 1.8:1. Wilms tumor was suspected in 13 (10.4%) children on MRI. The diagnosis of Wilms tumor was confirmed in 13 (10.4%) children on histopathology. MRI was found to be 76.9% sensitive, 97.3% specific and 95.2% accurate with positive and negative predictive values of 76.9% and 97.3% respectively. Conclusion: In the present study, MRI was found to be 95.2% accurate in the differential diagnosis of Wilms tumor in children presenting with retroperitoneal mass which along with its non-invasive and radiation free nature advocates the preferred use of MRI in the diagnostic evaluation of such children in future oncologic practice. Keywords: Retroperitoneal Tumor, Wilms Tumor, MRI, Diagnostic Accuracy

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“…The clinical importance of FLT3 and other mutations in relapsing patients was also studies in the said research and it was unearthed that FLT3 and one other mutation were the only ones linked to a decreased survival rate while NRAS did not exhibit nay mal-effect on clinical outcome or disease prognosis [13,14]. The mean age of the sample stood at 41 years (±19 SD) and the frequency of sample peaked at both extremes with most of the subjects being either ≤ 20 years or ≥ 50 years of age.…”

Section: Discussionmentioning

confidence: 99%

Molecular Characterization of Flt3 Mutation in Acute Leukemia

Ramzan

Aamir

Jamali³

et al. 2021

JPRI

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Background: Fms-like Tyrosine Kinase 3 (FLT3) has an important role to perform in hematopoietic malignancy pathogenesis. Hence the focus of several studies has recently been FLT3. Objective: To determine the molecular characterization of FLT3 mutation in patients of acute leukemia. Methodology: This descriptive analysis was carried out from January 2018 to December 2018 upon a sample of 94 newly diagnosed cases of acute leukemia (chosen via non-probability, consecutive sampling) presenting to the Department of Pathology, Liaquat University of Medical & Health Sciences, Jamshoro. After taking informed written consent, Data were obtained from laboratory records and patient interviews were noted down with the help of structured questionnaire. SPSS v. 20.0 was used for analysis of the obtained data. Results: The mean age of participants was 41 years (±19 SD). 59.57% of the sample comprised of males while the remaining 40.43% were females. Among the total of 94 patients studied, patients with acute lymphoblastic leukemia (ALL) were 41 in number while those with acute myeloid leukemia (AML) were 53. The polymerase chain reaction verified FLT3 mutations in 6 (11.32%) out of 53 AML cases and 2 (4.88%) among 41 ALL cases. In acute myeloid leukemia (AML) FLT3 mutation was more prevalent among the older age set (51 and above), while in acute lymphoblastic leukemia (ALL) the FLT3 mutation was more commonly seen a comparatively younger patient age set (21 to 30 years). Conclusion: It was found out that the FLT3 mutations are not uncommon in our study setting. With a greater prevalence observed among older male patients. AML was more common than ALL, with greater incidence rate of FLT3 mutations observed in the AML patients.

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Clinical characteristics of childhood cancer in emergency room in a tertiary hospital in Pakistan

Cited by 4 publications

References 15 publications

Childhood Leukemias in Khyber Pakhtunkhwa and Afghan Children Visiting to Hayatabad Medical Complex Hospital

Childhood Leukemias in Khyber Pakhtunkhwa and Afghan Children Visiting to Hayatabad Medical Complex Hospital

Accuracy of MRI in the Differential Diagnosis of Wilms Tumor

Molecular Characterization of Flt3 Mutation in Acute Leukemia

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