Childhood Leukemias in Khyber Pakhtunkhwa and Afghan Children Visiting to Hayatabad Medical Complex Hospital

Khan, Shahtaj; Mir, Awal; Khattak, Baber Rehman; Rehman, Ansa Kalsoom; Zeb, Asif

doi:10.21767/2254-6081.1000149

Cited by 7 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the subtypes of AML, the most frequent was AML with maturation similar to the reported literature. 19 Most published data indicated predominance of acute myeloid leukaemia with and without maturation similar to our study. TdT is a precursor lymphocyte marker, aberrantly expressed in AML.…”

Section: Discussionsupporting

confidence: 91%

“…Our study reported incidence (80.4%) of B-ALL which was similar to other Pakistani studies (78.5-87%) 10,15 as well as an Indian study by Madhumathi et al 16 However studies from West 10,14,17 reported between 72.9 and 91% frequency. Among lymphoblastic leukaemia, 13-23% of T-ALL cases were reported in other studies from Pakistan in last 10 years 10,11,15,18,19 while similar distribution was reported from India 12,13 with concordant distribution reported in the present study. Studies from West reported a relatively lower frequency.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Distribution of subtypes and immunophenotypic characterization of 1379 cases of paediatric acute leukaemia

et al. 2021

View full text Add to dashboard Cite

Objectives: Acute leukaemia is the most common and highly curable childhood malignancy; subtyping and identification of antigens via immunophenotyping helps in treatment plan as well as minimal residual disease monitoring. Methods: This retrospective study was conducted at the Haematology section of the clinical laboratories of Ziauddin University Hospital and The Indus Hospital, Karachi conducted at January 1st, 2012 to December 31st, 2017. The study included 1379 cases of de novo acute leukemia from 2012 to 2017. Among these, 80% were diagnosed by using four color flowcytometry (FACS Calibur), 9% and 11% via immunohistochemistry on bone marrow trephine biopsy samples and morphological examination respectively. Results: The mean age of patients was 7.4 ± 4.3 years while male to female ratio was 1.75:1. Lymphoblastic leukaemia accounted for 77.2% and myeloid leukaemia 21.2%. Amongst lymphoblastic lineage, B-ALL was 80.4% while T-ALL was 19.6%. Among the phenotypic expression of B-ALL, CD79a (99.8%) had the highest positivity. In B-ALL, CD13 (29.8%) was the most common aberrant myeloid marker. Aberrant expression of CD79a observed in 11.1% of T-ALL cases. In non APL AML, aberrant expression of CD79a and CD19 was observed in 6.6% and 5.5% of cases respectively. Conclusion: Overall immunophenotypic profile, expression of aberrant phenotypes and subtype distribution in our patients was similar to international literature except for a relatively high frequency of T-ALL which was discordant from the western data. doi: https://doi.org/10.12669/pjms.37.3.3552 How to cite this:Jamal S, Meraj F, Mansoor N, Parveen S, Shaikh A, Jabbar N. Distribution of subtypes and immunophenotypic characterization of 1379 cases of paediatric acute leukaemia. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3552 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Distribution of subtypes and immunophenotypic characterization of 1379 cases of paediatric acute leukaemia

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Khan, Mir, Khattak, Rehman, & Zeb, 2017). Mushtaq and colleagues reported B cell leukemia in 87% and T cell ALL in 13% of their patients (Mushtaq, Fadoo, & Naqvi, 2013). In this study, acute myelogenous leukemia was found in 10 (11.1%) with subtypes including AML-M5 (5.6%), AML-M2 and AML-M3 (2.2%), AML-M0 2 (2.2%) and AML-M2 (1.1%) (Table 4).…”

Section: Introductionmentioning

confidence: 51%

“…Childhood leukemia is one of the common malignancies in the pediatric population in Pakistan and globally, but local data on childhood leukemia is scarce. Khan, Mir, Khattak, Rehman, & Zeb, 2017). Mushtaq and colleagues reported B cell leukemia in 87% and T cell ALL in 13% of their patients (Mushtaq, Fadoo, & Naqvi, 2013).…”

Section: Introductionmentioning

confidence: 98%

Acute Leukemia in Children - An Inpatient Descriptive Study

AHMAD,

SALAHUDDIN,

AHMAD

2023

Biol Clin Sci Res J

View full text Add to dashboard Cite

Acute leukemia in children causes unacceptably high morbidity and mortality in the affected patients in our population. This study was undertaken to create local data that could be used to better understand the characteristics of this disease in our set up, provide better management to the affected children and help decrease the high morbidity and mortality associated with this disease. To determine the frequency of the significant classes of acute leukemia, its subclasses and rate of remission in our study population. This study was conducted in Pediatric B Unit, Department of Pediatrics, Hayatabad Medical Complex, Peshawar, from 1st June 2017 to 31st December 2018. Using consecutive sampling technique, 90 cases were selected. All children who underwent bone marrow examination during the study period in this hospital were included in the study. Data on age, gender, indications, and major types and subclasses of leukemia was extracted from bone marrow record forms of these children and analyzed using SPSS version 20. Means and standard deviations were calculated for age and frequency and percentages for gender, types, and subtypes of leukemia and remission. 90 patients were included in this study. TLC was low in 33 (36.7%). Normal in 24 (26.6%) and raised in 33(36.7%). Acute lymphoblastic leukemia- ALL -L1 accounted for 80 (88.9%) of cases, while acute myelogenous leukemia for 10(11.1%). Acute myelogenous leukemia subtypes included AML-M5 in 5 (5.6%), AML-M2 and AML-M3 (2.2%) AML-M0 2 (2.2%), and AML-M2 1 (1.1%). 43 (47.8%) were newly diagnosed cases. 47 (52.2%) were previously diagnosed cases, of which 26 (55.3%) were in remission. Acute lymphoblastic leukemia ALL-L1 was the commonest type of leukemia with ALL-L1 subtype in all patients followed by acute myelogenous leukemia with AML-M5 the commonest subtype. Rate of response to therapy was 55.3%.

show abstract

“…In addition, it was also observed that 210 (74.73%) of them had acute lymphoblastic leukemia, 62 (22.06%) acute myeloid leukemia, 7 (2.44%) chronic myeloid leukemia, 2 (0.71%) had Juvenile Chronic Myelomonocytic Leukemia (JMML) and 1 (0.35%) Chronic Myelomonocytic leukemia (CMML). No specific pattern of occurrence of childhood leukemia in Afghani children could be established form this study [4]. It is recommended that further studies on the same must and should be conducted to get further insights into the matter.…”

mentioning

confidence: 91%

Editorial Note: Archives in Cancer Research Volume 5, Issue 3

Bidwai¹

2017

Arch Can Res

View full text Add to dashboard Cite

Cancer research implies the methodically planned research studies that intend to elucidate any/all aspects of pathogenic, biochemical, molecular as well as pathological basis of carcinogenesis as well as metastasis of cancer cells. Considering the growing medical burden of cancer on a global scale, it becomes imperative that such studies are conducted, and their findings implemented for the development of newer and better anti-cancer therapeutic regimens. The Archives in Cancer Research journal is specifically intended for the global dissemination of such studies and their findings so that they can help in accentuation of the above described process. The current issue of the journal published many research articles and case reports that serve to enhance the persisting levels of clinical knowledge and skills required for the diagnosis and treatment of cancer.

show abstract

Childhood Leukemias in Khyber Pakhtunkhwa and Afghan Children Visiting to Hayatabad Medical Complex Hospital

Cited by 7 publications

References 9 publications

Distribution of subtypes and immunophenotypic characterization of 1379 cases of paediatric acute leukaemia

Distribution of subtypes and immunophenotypic characterization of 1379 cases of paediatric acute leukaemia

Acute Leukemia in Children - An Inpatient Descriptive Study

Editorial Note: Archives in Cancer Research Volume 5, Issue 3

Contact Info

Product

Resources

About