Clinical Characteristics of Becker’s Nevus in Children: Report of 118 Cases from Italy

Patrizi, Annalisa; Medri, Matelda; Raone, Beatrice; Bianchi, Federica; Aprile, Sylvia; Neri, Iria

doi:10.1111/j.1525-1470.2012.01734.x

Cited by 36 publications

(44 citation statements)

References 11 publications

(15 reference statements)

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“…However, there are only a few systematic studies of its clinicopathologic features234. The immunohistochemical observations of other indexes are nearly unavailable in BN except androgen receptor and melanocyte25.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus

et al. 2016

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BackgroundAlthough Becker's nevus (BN) is a relatively common disease, the systematic studies of clinicopathological and immunohistochemical results are poorly reported.ObjectiveTo investigate the clinicopathological features and immunohistochemical alterations of keratinocyte proliferation, melanocyte density, smooth muscle hyperplasia and nerve fiber distribution in BN.MethodsClinical and pathological data were collected in 60 newly-diagnosed BN cases. Immunohistochemical stain of Ki-67, Melan-A, keratin 15, smooth muscle actin and protein gene product 9.5 was performed in 21 cases.ResultsThe median diagnostic and onset age was 17 and 12 years, respectively. Skin lesions usually appeared on the upper trunk and upper limbs. The pathological features included the rete ridge elongation and fusion and basal hyperpigmentation. Epidermal Ki-67, Melan-A and keratin 15 expression and dermal nerve fiber length were significantly higher in lesional and perilesional skin than in normal skin (p<0.05~0.01), while smooth muscle actin expression was upregulated only in skin lesion (p<0.05).ConclusionAlthough the clinical diagnosis of BN is often straightforward, histopathology is helpful to differentiate from other pigmentary disorders. The hyperproliferation of keratinocytes, melanocytes, arrector pili muscle and dermal nerve fibers could be involved in the pathogenesis of BN.

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Section: Introductionmentioning

confidence: 99%

Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus

et al. 2016

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“…Becker nevi are occasionally congenital but more commonly appear during adolescence due to a localized increase in androgen receptor sensitivity within the nevus [61]. A recent retrospective study of 118 children in Italy with a diagnosed Becker nevus showed a nearly equal distribution among sexes (47 % male) in contrast to the common assumption of predominance in adolescent males [62]. Hypertrichosis also was present in only one-third of cases as compared to the presence of terminal hairs in the Becker nevi of 70 % of young Italian men [63].…”

Section: Other Pigmented Lesionsmentioning

confidence: 83%

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012

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Pigmented lesions and melanocytic nevi are commonly evaluated lesions in pediatric dermatology clinics and the rising incidence of melanoma has increased public awareness of malignant potential. Diagnosis and management of pigmented lesions, especially dysplastic nevi, medium and large congenital melanocytic nevi (CMN), and Spitz nevi, can be particularly challenging. We summarize the recent literature for melanocytic nevi and pigmented lesions as relevant to the practice of pediatric dermatology with particular attention to dermatoscopic techniques, histopathologic interpretation, molecular biology, and management recommendations for CMN and Spitz nevi.

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“…Most studies in adults show a five times greater incidence in men than women, but few other studies have revealed a female predominance [2]. The higher incidence in men reported in adult case studies has not been found in children [3]. Histological evaluation reveals acanthosis, epidermic hyperpigmentation, papillomatosis, arrector pili muscle hyperplasiam and melanophages in dermis [4].…”

Section: Discussionmentioning

confidence: 99%

Becker’s Nevus Syndrome in a Pediatric Female Patient

Hernandez-Quiceno

Uribe-Bojanini

Ramírez-Jiménez

et al. 2016

Case Reports in Pediatrics

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Becker's nevus syndrome is part of the epidermal nevus syndromes and has been described with a phenotype that includes Becker's nevus, ipsilateral breast hypoplasia, and variable skeletal malformations. It is more frequent in males than in females (5 : 1) but is more relevant in females. The diagnosis is clinically based and the skin lesion must be present and no other numbered criteria have been established, but with more criteria being present the possibility of the diagnosis is higher. Regarding the treatment of breast hypoplasia, the use of antiandrogen medication has demonstrated adequate clinical response in a dose of 50 mg/day of spironolactone.

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Clinical Characteristics of Becker’s Nevus in Children: Report of 118 Cases from Italy

Cited by 36 publications

References 11 publications

Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus

Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

Becker’s Nevus Syndrome in a Pediatric Female Patient

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