Clinical characteristics associated with esophageal motility function

Tanaka, Yoshimasa; Ihara, Eikichi; Nakamura, Kazuhiko; Muta, Kazumasa; Fukaura, Keita; Mukai, Kosuke; Bai, Xiaopeng; Takayanagi, Ryoichi

doi:10.1111/jgh.13262

Cited by 20 publications

(20 citation statements)

References 30 publications

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“…Also body weight, height, BMI could be predictive factors of esophageal motility. 47 The limitation of the present study is that almost all subjects were symptomatic although there was no major esophageal motility disorder according to the 3.0 Chicago classification of esophageal motility. Initially we planned to perform this study in age matched normal subjects.…”

Section: Discussionmentioning

confidence: 98%

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Effects of Age on Esophageal Motility: Use of High-resolution Esophageal Impedance Manometry

Shim

Kim

Park

et al. 2017

J Neurogastroenterol Motil

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Background/AimsDisturbances of esophageal motility have been reported to be more frequent the aged population. However, the physiology of disturbances in esophageal motility during aging is unclear. The aim of this study was to evaluate the effects of age on esophageal motility using high-resolution esophageal impedance manometry (HRIM). MethodsEsophageal motor function of 268 subjects were measured using HRIM in 3 age groups, < 40 years (Group A, n = 32), 40-65 years (Group B, n = 185), and > 65 years (Group C, n = 62). Lower esophageal sphincter (LES) and upper esophageal sphincter (UES) pressures, integrated relaxation pressure, distal contractile integral, contractile front velocity, distal latency, and pressures and duration of contraction on 4 positions along the esophagus, and complete bolus transit were measured. ResultsBasal UES pressure was lower in Group C (P < 0.001) but there was no significant difference in the LES pressure among groups. Contractile duration on position 3 (10 cm from proximal LES high pressure zone) was longer in Group C (P = 0.001), and the contractile amplitude on position 4 (5 cm from proximal LES high pressure zone) was lower in Group C (P = 0.005). Distal contractile integral was lower in Group C (P = 0.037). Contractile front velocity (P = 0.015) and the onset velocity (P = 0.040) was lower in Group C. There was no significant difference in impedance values. ConclusionsThe decrease of UES pressure, distal esophageal motility, and peristaltic velocity might be related with esophageal symptoms in the aged population.

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Section: Discussionmentioning

confidence: 98%

“…Recently published studies showed the correlation with esophageal motility and body weight, height, BMI. Study by Tanaka et al 47 described that there was inverse correlation with BMI and DCI, total cholesterol and DCI, BMI, and IRP. Also body weight, height, BMI could be predictive factors of esophageal motility.…”

Section: Discussionmentioning

confidence: 99%

Effects of Age on Esophageal Motility: Use of High-resolution Esophageal Impedance Manometry

Shim

Kim

Park

et al. 2017

J Neurogastroenterol Motil

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“…Comparatively, functional OO with intact peristalsis was observed in only 0.016% among 1000 consecutive HRM studies [19]. The association between high glucose and cholesterols levels, caused by high fat and sugar intake in morbidly obese patients, and the integrated relaxation pressure as well as an increased intraabdominal pressure, may offer an explanation for this difference in prevalence [20]. Nevertheless, therapeutic consequences and impact of bariatric surgery on the evolution of OO still remain unclear [21].…”

Section: Discussionmentioning

confidence: 99%

Modern Esophageal Function Testing and Gastroesophageal Reflux Disease in Morbidly Obese Patients

et al. 2019

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Background The implementation of high-resolution manometry (HRM) and the Lyon Consensus statement facilitate evaluation of gastroesophageal reflux disease and motility disorders in morbidly obese patients. Therefore, we aimed to investigate prevalence and phenotype of (borderline) GERD and esophageal motility disorders in this population. Methods Consecutive morbidly obese (BMI ≥ 35 kg/m 2 ) patients were offered evaluation by means of HRM, ambulatory 24-h pH impedance monitoring, endoscopy, and a clinical examination at our tertiary academic center. Data were collected prospectively.Results Out of 448 eligible individuals, 147 patients (females = 75, 51%) with a median age of 41.6 (33.4; 52.3) years and a BMI of 44 (40.9; 49.4) kg/m 2 were included during the study period. The Chicago Classification revealed motility disorders in 50 (34%) patients, dominated by outflow obstruction (18.4%, n = 27) and a novel disorder (7.5%, n = 11), nicknamed jackhammer esophagus (JE). According to the Lyon Consensus, 52 (35.4%) patients had evidence of true GERD, whereas borderline GERD was noted in another 60 (40.8%). Hypersensitive esophagus was observed in 6.8% (n = 10). Sensitivity and specificity of symptoms for GERD were 53.8% and 68.4%, respectively. Conclusions The current gold standard of assessment revealed that the prevalence of esophageal motility disorders and (borderline) GERD is high in the morbidly obese population. Further longitudinal data are needed to delineate the natural course of novel motility disorders like JE in obesity and to identify risk factors for adverse outcomes following bariatric surgery.

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“…In a separate analysis of reflux scores and dyspepsia scores, however, BMI was associated with more reflux symptom and fewer dyspepsia symptoms. GERD, which is mainly based on reflux symptoms, has a multifactorial pathogenesis, including the presence of excess gastric acid (34), hiatal hernia (35), lower esophageal sphincter (LES) dysfunction (36,37) and esophageal motility dysfunction (38). Aging is a major risk factor for GERD (39).…”

Section: Discussionmentioning

confidence: 99%

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with <i>Miso</i> Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study

Mano

Ikeda

Sato

et al. 2018

Journal of Nutritional Science and Vitaminology

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Dietary habits and lifestyles are considered to affect the frequency of epigastric symptoms. In our previous study, we found that three amino acids in Japanese broth promoted gastric emptying. We hypothesized that a higher consumption of miso soup which was mainly composed of Japanese broth and miso paste would be associated with a lower frequency of epigastric symptoms. We conducted a cross-sectional study of the association between frequency of miso soup intake and reflux or dyspepsia symptoms in a general Japanese population. Sixteen items of dietary habits were assessed using a self-reported questionnaire, and epigastric symptoms were evaluated using the Frequency Scale for Symptoms of Gastroesophageal Reflux Disease (FSSG). We fitted generalized linear models to analyze the association between miso soup intake and FSSG, reflux, or dyspepsia scores adjusted by age, sex, body mass index (BMI), another 15 dietary habits, smoking, drinking alcohol, and unfavorable dietary behaviors. A total of 9,364 subjects were included in the analysis. Trend analysis revealed that higher frequency of miso soup intake was associated with lower FSSG scores (p,0.001). In a generalized linear model, daily intake of miso soup was associated with lower FSSG, reflux, and dyspepsia scores independent of age, sex, BMI, other 15 dietary habits, smoking, drinking alcohol, and unfavorable dietary behaviors (estimate520.

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Clinical characteristics associated with esophageal motility function

Abstract: Both BMI and total cholesterol could be highly predictive factors for esophageal body contractility, while BMI and glucose could be predictive factors for lower esophageal sphincter contractile function.

Cited by 20 publications

References 30 publications

Effects of Age on Esophageal Motility: Use of High-resolution Esophageal Impedance Manometry

Effects of Age on Esophageal Motility: Use of High-resolution Esophageal Impedance Manometry

Modern Esophageal Function Testing and Gastroesophageal Reflux Disease in Morbidly Obese Patients

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with <i>Miso</i> Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study

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