Clinical characteristics and short-term outcomes of acute pancreatitis among patients with COVID-19

Zhang, Jinchang; Luo, De; Kang, Maoji; Li, Bo; Su, Song

doi:10.1186/s40001-023-01252-x

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Furthermore, the authors believe that these differences were probably due to restrictive measures implemented during the pandemic period, consequent delay in care, and a restriction on surgical treatment indications [34]. Conversely, a more recent study directly compared SARS-CoV-2-positive patients and SARS-CoV-2-negative patients, both diagnosed with AP, and it found no differences regarding mortality rate, severity, or sequelae [35].…”

Section: Discussionmentioning

confidence: 93%

COVID-19 and Acute Pancreatitis: Not Increased Risk but Reduced Care

Cevolani,

Ferronato,

Lizzio

et al. 2023

Gastroenterology Insights

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Background and aim: Over the last few years, SARS-CoV-2 has been reported as a possible cause of acute pancreatitis (AP), but whether it is a relevant clinical–epidemiological entity is still a matter of debate. We aim to evaluate the epidemiological characteristics of AP during the first year of the COVID pandemic (2020) and compare them with the pre-COVID period (2008–2019) to identify any differences and clarify a potential causative role of SARS-CoV-2. Methods: We used a monocentric retrospective study of 132 AP patients during 2020 and 1987 AP patients during 2008–2019. Diagnosis and severity were classified according to the revised Atlanta criteria. Propensity score matching was performed according to clinical–epidemiological features, and outcome analysis was performed on two subgroups of 109 patients. Results: The total number of AP cases in 2020 is one of the lowest in the last 13 years (132 cases, median 161, IQR 146-183). No major epidemiological differences were noted. During 2020, we observed a significant modification of the distribution of etiologies (p < 0.001), mainly based on a decrease in biliary forms (59.6% vs. 43.2%) and an increase in alcoholic forms (6.9% vs. 12.9%). Idiopathic forms remain unchanged (20.5% vs. 21.9%). The proportion of AP of idiopathic etiology and SARS-CoV-2 infection was 0.008%. There were no differences in terms of severity distribution (p = 0.127), length of stay (p = 0.916), need for ICU (p = 0.139), or mortality (p = 0.462). Even among statistically matched groups, there were no differences between the length of stay (9 vs. 10 days, p = 0.890), need for ICU admission (1.8% vs. 3.7%, p = 0.683), or in-hospital mortality (0 vs. 1.8%, p = 0.342). Conclusions: The lower AP diagnoses indicate delayed and likely missed diagnoses, probably because of both hesitancy and organizational problems during the pandemic. The unchanged proportion of idiopathic forms supports the hypothesis that SARS-CoV-2 is not an AP trigger.

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Section: Discussionmentioning

confidence: 93%

COVID-19 and Acute Pancreatitis: Not Increased Risk but Reduced Care

Cevolani,

Ferronato,

Lizzio

et al. 2023

Gastroenterology Insights

View full text Add to dashboard Cite

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“…Nevertheless, retrospective research conducted in Spain indicated a potential correlation between COVID‐19 and a decreased likelihood of AP 28 . A retrospective investigation conducted at a single facility in Sichuan, China, revealed that COVID‐19 did not increase the severity or fatality rates among individuals diagnosed with pancreatitis 29 . According to retrospective research conducted in South Korea, it was shown that the incidence of AP increased in individuals who contracted COVID‐19.…”

Section: Discussionmentioning

confidence: 99%

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Ge,

Luo,

Liu

et al. 2023

Journal of Medical Virology

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The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID‐19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID‐19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID‐19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID‐19 and CP. A direct causal relationship between genetically predicted COVID‐19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID‐19 as a definitive cause of pancreatitis.

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“…Many individuals frequently report experiencing significant fatigue, even when engaging in minimal levels of physical or cognitive activity. The presence of fatigue may be accompanied by a widespread feeling of malaise and a decreased ability to participate in previously habitual activities [ 5 ]. Cognitive impairments, commonly known as "brain fog," are frequently reported by individuals with long COVID.…”

Section: Reviewmentioning

confidence: 99%

Unveiling the Mysteries of Long COVID Syndrome: Exploring the Distinct Tissue and Organ Pathologies Linked to Prolonged COVID-19 Symptoms

Sapna,

Deepa,

Sakshi

et al. 2023

Cureus

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The ongoing battle against the coronavirus disease 2019 (COVID-19) pandemic has encountered a complex aspect with the emergence of long COVID syndrome. There has been a growing prevalence of COVID-19-affected individuals experiencing persistent and diverse symptoms that extend beyond the initial infection phase. The phenomenon known as long COVID syndrome raises significant questions about the underlying mechanisms driving these enduring symptoms. This comprehensive analysis explores the complex domain of long COVID syndrome with a view to shed light on the specific tissue and organ pathologies contributing to its intricate nature. This review aims to analyze the various clinical manifestations of this condition across different bodily systems and explore potential mechanisms such as viral persistence, immune dysregulation, autoimmunity, and molecular mimicry. The goal is to gain a better understanding of the intricate network of pathologies contributing to long COVID syndrome. Understanding these distinct pathological indicators provides valuable insights into comprehending the complexities of long COVID and presents opportunities for developing more accurate diagnostic and therapeutic strategies, thereby improving the quality of patient care by effectively addressing the ever-changing medical challenge in a more focused manner.

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Clinical characteristics and short-term outcomes of acute pancreatitis among patients with COVID-19

Cited by 3 publications

References 41 publications

COVID-19 and Acute Pancreatitis: Not Increased Risk but Reduced Care

COVID-19 and Acute Pancreatitis: Not Increased Risk but Reduced Care

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Unveiling the Mysteries of Long COVID Syndrome: Exploring the Distinct Tissue and Organ Pathologies Linked to Prolonged COVID-19 Symptoms

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