Clinical characteristics and risk factors for SARS-CoV-2 infection in pregnant women attending a third level reference center in Mexico City

Hernández-Cruz, Rosa Gabriela; Sánchez-Cobo, Daniela; Acevedo‐Gallegos, Sandra; Helguera-Repetto, Addy Cecilia; Rodríguez-Bosch, Mario Roberto; Ramírez-Santes, Víctor Hugo; Villegas-Mota, Isabel; Cardona-Pérez, Arturo; Cortés-Bonilla, Manuel; Irles, Claudine; Mateu-Rogell, Paloma; Villanueva-Calleja, Job; Villavicencio-Carrisoza, Oscar; Estrada-Gutiérrez, Gaudalupe; Sosa, Salvador Espino Y; Torres-Torres, Johnatan; Martinez‐Portilla, R.J.

doi:10.1080/14767058.2021.1902500

Cited by 7 publications

(10 citation statements)

References 13 publications

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“…Our findings are in agreement with reports showing that most SARS-CoV-2-positive pregnant women are asymptomatic or have mild disease [19][20][21] . The most frequently reported symptom in our group after discharge was headache, which has been associated with COVID-19 22 , but is also a common postpartum symptom.…”

Section: Discussionsupporting

confidence: 93%

Evidence of possible SARS‐CoV‐2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women

Sevilla-Montoya¹,

Hidalgo-Bravo²,

Estrada-Gutiérrez

et al. 2021

Ultrasound in Obstet & Gyne

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The findings of this study provide evidence of possible vertical transmission of severe acute respiratory sydrome coronavirus 2 (SARS-CoV-2) in asymptomatic pregnant women, using the novel World Health Organizaton criteria for the establishment of mother-to-child transmission of SARS-CoV-2. The presence of SARS-CoV-2 RNA in amniotic fluid and its persistence in the neonate 24 h after birth was demonstrated. What are the clinical implications of this work?This work highlights the importance of testing more than one sample for SARS-CoV-2 in neonates of asymptomatic infected women in order to increase the detection rate in positive cases. Identification of neonatal SARS-CoV-2 infection might help clinicians to understand better the long-term effects or complications of the disease.

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Section: Discussionsupporting

confidence: 93%

Evidence of possible SARS‐CoV‐2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women

Sevilla-Montoya¹,

Hidalgo-Bravo²,

Estrada-Gutiérrez

et al. 2021

Ultrasound in Obstet & Gyne

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“…Previous studies reported relatively higher prevalence of COVID-19 infection among pregnant women all over the world, ranging 1·3%~30·74% [10] , [11] . In one study from the United States, tests of all pregnant women who admitted to two New-York based delivery hospitals confirmed 15·6% of COVID-19 infection, including 1·9% of symptomatic pregnant women and 13·7% of asymptomatic COVID-19 infection [13] .…”

Section: Discussionmentioning

confidence: 91%

“…Until now, there is a paucity of information regarding the actual prevalence of COVID-19 infection in pregnant women compared to non-pregnant women. Previous studies from United States, United Kingdom, and other countries throughout the world reported relatively higher prevalence of COVID-19 among pregnant women (ranged from 1·3%~30·74% [10] , [11] ). However, the studies focused only on pregnant women, limiting comparability of actual prevalence between pregnant and non-pregnant women.…”

Section: Introductionmentioning

confidence: 89%

Impact of COVID-19 on pregnant women in South Korea: Focusing on prevalence, severity, and clinical outcomes

Kim

Choi

Lee

et al. 2022

Journal of Infection and Public Health

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Background In the era of coronavirus disease 2019 (COVID-19) pandemic, there is a paucity of information regarding actual prevalence of COVID-19 in pregnant women compared to non-pregnant women. The purpose of this study was to investigate the prevalence of COVID-19 infection and clinical outcome in pregnant women and non-pregnant women. Methods This is a nationwide cross-sectional study in South Korea between January 2020 and February 2021 using the claim database. The primary outcome was the prevalence of COVID-19 in pregnant women, and the secondary outcome was the occurrence of severe COVID-19 illness among infected patients. Severity of COVID-19 was classified into four categories according to WHO ordinal scale. Results The prevalence of COVID-19 infection was lower in pregnant women than non-pregnant women aged 20-44 (0·02% vs. 0·14%, p<0.0001). However, among COVID-19 positive women at age 20-44, pregnant women was at higher risk of oxygen therapy after hospitalization (score 4 in WHO ordinal scale: 6.4% vs. 1.6%, p<0.05). There were no deaths or hospitalized severe disease in pregnant women with COVID-19, although the majority of them (96·2%) were admitted to hospital. On the other hand, 42·3% of non-pregnant women at 20-44 age were admitted to hospital and 0·04% of them died and 0·1% had hospitalized severe disease. Conclusions The prevalence of COVID-19 infection in pregnant women was lower than non-pregnant women in Korea, resulting in relatively small cases of fatality. It has implications that public health policy, such as an effective response to COVID-19 and a powerful preemptive strategy for pregnant women, can lower risk of COVID-19 infection and better clinical outcomes in pregnant women with COVID-19.

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“…This large referral center for perinatal health care has one of the highest prevalences of SARS-CoV-2 among pregnant women, around 30%. However, less than 3% of patients were symptomatic [ 13 , 14 ]. The mild to moderate symptoms associated with SARS-CoV-2 infection were headache, dyspnea, myalgia, and olfactory/gustatory dysfunction [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, less than 3% of patients were symptomatic [ 13 , 14 ]. The mild to moderate symptoms associated with SARS-CoV-2 infection were headache, dyspnea, myalgia, and olfactory/gustatory dysfunction [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

Laresgoiti-Servitje

Cardona–Pérez

Hernández-Cruz

et al. 2021

Viruses

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(1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (CT) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and CT values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between CT values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low CTs (<25; p < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or CT values (p < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation.

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Clinical characteristics and risk factors for SARS-CoV-2 infection in pregnant women attending a third level reference center in Mexico City

Cited by 7 publications

References 13 publications

Evidence of possible SARS‐CoV‐2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women

Evidence of possible SARS‐CoV‐2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women

Impact of COVID-19 on pregnant women in South Korea: Focusing on prevalence, severity, and clinical outcomes

COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

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