Clinical Characteristics and Reproductive Outcomes in Infertile Men With Testicular Early and Late Maturation Arrest

Tsai, M.C.; Cheng, Yu‐Sheng; Lin, Tsung-Yen; Yang, Wen-Horng; Lin, Yung Ming

doi:10.1016/j.urology.2012.06.054

Cited by 25 publications

(18 citation statements)

References 26 publications

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“…We found a higher SRR rate in men who had late MA, compared with men who had early MA (6,7). Men who had late MA in our series were almost twice as likely to have sperm retrieved, compared with men who had early MA (78% vs. 40%).…”

Section: Discussioncontrasting

confidence: 38%

“…Although previous studies have looked at men who have MA (6,7,10), no well-defined criteria have been established for determining if a patient is considered to have diffuse or focal MA. Thus, we established a classification scheme intended to delineate the 2 groups.…”

Section: Methodsmentioning

confidence: 99%

“…Both Tsai et al (6) and Weedin et al (7) found that, compared with men with late MA, those diagnosed with early MA had a decreased probability of successful sperm retrieval. Due to the limited number of cases in prior publications, histopathology could not be used to predict successful TESE.…”

Section: Introductionmentioning

confidence: 98%

“…It is further delineated into early and late MA, based on the mostmature cell type noted on histology. In early MA, spermatogenic arrest occurs at the spermatogonia or spermatocyte stage; in late MA, arrest occurs at the spermatid stage (5)(6)(7). Late MA is distinguished from hypospermatogenesis in that no condensed, oval spermatids are seen in late MA.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Outcomes of microdissection testicular sperm extraction in men with nonobstructive azoospermia due to maturation arrest

Bernie

Shah

Halpern

et al. 2015

Fertility and Sterility

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Section: Discussioncontrasting

confidence: 38%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outcomes of microdissection testicular sperm extraction in men with nonobstructive azoospermia due to maturation arrest

Bernie

Shah

Halpern

et al. 2015

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…1 Several factors have been evaluated and reported for prediction of sperm retrieval rates including but not limited to FSH 2,3,4 , however no one single factor has been found to correlate with success. Men with NOA usually have smaller testicles than men with obstructive azoospermia 5 , except those with early or late maturation arrest histology 6 . Studies to date, however, have only shown poor correlations between testicular size and sperm retrieval rates, 7,8 though no study has specifically evaluated the effectiveness of micro-TESE in men with severe testicular atrophy.…”

Section: Introductionmentioning

confidence: 98%

Severe testicular atrophy does not affect the success of microdissection testicular sperm extraction

Ramasamy

Bryson

Palermo

et al. 2013

Fertility and Sterility

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Challenges in differential diagnosis between obstructive and non‐obstructive azoospermia

Gamidov,

Shatylko,

Tambiev

et al. 2024

UroPrecision

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BackgroundSome cases of non‐obstructive azoospermia (NOA) are characterized by normal clinical parameters, including testicular volume and levels of reproductive hormones, mimicking obstructive azoospermia (OA).MethodsWe performed a retrospective review of a consecutive series of 1417 patients undergoing primary surgical sperm retrieval between 2014 and 2023. Follicle‐stimulating hormone (FSH) level below 7.6 IU/l and normal testicular size with a long axis measurement >4.6 cm were used as criteria to suspect OA.ResultsFour hundred and eighteen patients with normal testicular volume and FSH levels had an initial diagnosis of OA. Among them, 243 (58.1%) had histological signs of spermatogenic dysfunction, and 175 (41.9%) had true OA. One hundred eleven patients had long‐standing obstruction (median: 16.5 years) with a median Bergmann–Kliesch score (BKS) of 5 (interquartile range [IQR]: 4–6) and 100% sperm retrieval rate (SRR), though some required microdissection testicular sperm extraction (microTESE). Fifty‐eight patients with a history of epididymo‐orchitis had a median BKS of 4 (IQR: 2–6) and 100% SRR. Twenty patients with a history of unjustified medical treatment for male infertility had a median BKS of 3 (IQR: 1–4) and 80% SRR. Fifty‐four patients had uniform maturation arrest with a 5.5% SRR on microTESE.ConclusionMen with normal testicular volume and FSH level may have evidence of spermatogenic failure on pathology. Patients with complicated seminal tract obstruction commonly have hypospermatogenesis, but true NOA caused by uniform maturation arrest may also be observed. Patient counseling for suspected OA should not be overly optimistic, and couples should be warned about possibility of conversion to microTESE and risks of negative sperm retrieval.

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Clinical Characteristics and Reproductive Outcomes in Infertile Men With Testicular Early and Late Maturation Arrest

Cited by 25 publications

References 26 publications

Outcomes of microdissection testicular sperm extraction in men with nonobstructive azoospermia due to maturation arrest

Outcomes of microdissection testicular sperm extraction in men with nonobstructive azoospermia due to maturation arrest

Severe testicular atrophy does not affect the success of microdissection testicular sperm extraction

Challenges in differential diagnosis between obstructive and non‐obstructive azoospermia

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