Clinical Characteristics and Predictors of Outcome of Schizophrenia-Spectrum Psychosis in Children and Adolescents: A Systematic Review

Abstract

EOS patients suffer substantial impairment from significant levels of positive and negative symptoms. Although symptoms and functioning improve significantly over time, pre-/and comorbid conditions are frequent, and longer DUP and poorer premorbid adjustment is associated with poorer illness outcome.

Die Aufmerksamkeitsdefizit- und Hyperaktivitätsstörung (ADHS) in der Erwachsenenpsychiatrie: Erfassung der ADHS-12-Monatsprävalenz, der Risikofaktoren und Komorbidität bei ADHS

“…Die hohe Zahl der Patienten mit Depressionen ist auch dem Umstand geschuldet, dass wir auf der von uns untersuchten Station primär Patienten mit affektiven Störungen aufnahmen. Die Patienten mit ADHS litten häufig an bipolaren Störungen, paranoiden Schizophrenien, Angststörungen, emotional-instabilen und zwanghaften Persönlichkeitsstörungen, Teilleistungsstörungen, Nikotinabhängigkeit, Substanzabhängigkeiten, Substanzmissbräuchen, Restless-legs Syndromen, Essstörungen und Adipositas, was auch andere Autoren beschrieben [2,5,7,10,11,16,17,18,19,20,21,22,23,24,25,26,27]. Bei der schizoaffektiven Störung, Zwangsstörung und organischen Persönlichkeitsstörung fanden sich keine Häufungen.…”

Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

“…A worse premorbid adjustment in patients with schizophrenia is associated with severity of negative symptoms, neurocognitive impairment, and poor functional outcome (8)(9)(10)(11)(12)(13). To further characterize these associations, several studies explored them by taking into account the distinction of premorbid functioning in two separate subdomains (i.e.…”

Early and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database

“…Second, from VEOS to EOS to AOS groups, there was also an increase in severity, with longer DUP (8.1 years vs. 1.8 years and 1.0 years respectively) and more pronounced symptomatology (psychopathology general PANSS score and total PANSS score). Although DUP has been previously investigated in EOS (Diaz‐Caneja et al, ; Joa et al, ; Stentebjerg‐Olesen, Pagsberg, Fink‐Jensen, Correll, & Jeppesen, ), the present study is the first to examine DUP in VEOS patients. This could be partly explained by the difficulty in diagnosing childhood schizophrenia (Gochman et al, ).…”