Early and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database

Coulon, Nathalie; Godin, O.; Bulzacka, E.; Dubertret, Caroline; Mallet, J.; Fond, Guillaume; Brunel, L.; Andrianarisoa, M.; Anderson, Geoffrey M.; Chéreau, Isabelle; Denizot, H.; Rey, Romain; Dorey, Jean‐Michel; Lançon, Christophe; Faget, Catherine; Roux, Paul; Passerieux, Christine; Dubreucq, Julien; Leignier, Sylvain; Capdevielle, Delphine; Meynier, André; Aouizerate, Bruno; Misdrahi, D.; Berna, Fabrice; Vidailhet, Pierre; Leboyer, Marion; Schürhoff, Franck

doi:10.1002/brb3.1495

Cited by 43 publications

(38 citation statements)

References 67 publications

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“…A long duration of untreated psychosis (DUP), compared to EOS, due to the difficult diagnosis and the hesitation in starting pharmacotherapy, further worsens the risk of negative prognosis [ 75 ]. The DUP for EOS lasts until 5–3 times more than the duration of untreated psychosis of adult SCZ [ 76 ].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Although VEOS and EOS are rare compared to the adult onset SCZ, and differ in some clinical features, diagnostic criteria are grossly the same, and allow timely diagnosis and treatment, with positive implications on short- and long-term prognosis. Close monitoring of UHR subjects can further increase the implementation of effective treatments, allowing us for an early recognition and more timely treatments in those who convert to fully developed psychosis (who should be the only to receive a pharmacological treatment) [ 76 ].…”

Section: Pharmacological Treatments In Early Onset Schizophreniamentioning

confidence: 99%

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A Neurodevelopment Approach for a Transitional Model of Early Onset Schizophrenia

Berardis

Filippis²,

Masi

et al. 2021

Brain Sciences

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In the last decades, the conceptualization of schizophrenia has dramatically changed, moving from a neurodegenerative process occurring in early adult life to a neurodevelopmental disorder starting be-fore birth, showing a variety of premorbid and prodromal symptoms and, in relatively few cases, evolving in the full-blown psychotic syndrome. High rates of co-occurring different neurodevelopmental disorders such as Autism spectrum disorder and ADHD, predating the onset of SCZ, and neurobio-logical underpinning with significant similarities, support the notion of a pan-developmental disturbance consisting of impairments in neuromotor, receptive language, social and cognitive development. Con-sidering that many SCZ risk factors may be similar to symptoms of other neurodevelopmental psychi-atric disorders, transition processes from child & adolescent to adult systems of care should include both high risk people as well as subject with other neurodevelopmental psychiatric disorders with different levels of severity. This descriptive mini-review discuss the need of innovative clinical approaches, re-considering specific diagnostic categories, stimulating a careful analysis of risk factors and promoting the appropriate use of new and safer medications.

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Pharmacological Treatments In Early Onset Schizophreniamentioning

confidence: 99%

A Neurodevelopment Approach for a Transitional Model of Early Onset Schizophrenia

Berardis

Filippis²,

Masi

et al. 2021

Brain Sciences

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“…Saat ini, terdapat sejumlah penelitian yang membandingkan skor skala PANSS (total skor, skala positif, skala negatif, psikopatologi umum) pada skizofrenia awitan remaja dan dewasa, namun tidak membandingkan setiap item dari setiap skala pada instrumen PANSS. [9][10][11] Penelitian ini bertujuan untuk mengetahui karakteristik demografi dan membandingkan skor PANSS (total skor, skala positif, skala negatif, skala psikopatologi umum) serta setiap item dari masing-masing skala antara pasien skizofrenia awitan remaja dan awitan dewasa.…”

Section: Pendahuluanunclassified

“…19 Dari hasil penelitian ini, ditemukan bahwa tidak ada perbedaan skor PANSS antara skizofrenia awitan remaja dan awitan dewasa (Tabel 2). Pada penelitian sebelumnya oleh Coulon et al (2020), ditemukan perbedaan pada skala negatif, skala psikopa- Populasi skizofrenia dengan awitan remaja (rentang usia 13-18 tahun) jumlahnya lebih sedikit, oleh karena skizofrenia pada umumnya muncul pada usia dewasa. 24 Menurut beberapa penelitian empiris, skizofrenia dengan awitan remaja didominasi oleh laki-laki, pendidikan rendah, lebih banyak kelainan struktur pada otaknya, dan memiliki gejala negatif yang lebih besar.…”

Section: Diskusiunclassified

Perbandingan Skor Positive and Negative Syndrome Scale Antara Skizofrenia Awitan Remaja dan Awitan Dewasa

Gracianita¹,

Pandia

Iskandar

et al. 2020

J Indon Med Assoc

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Pendahuluan: Skizofrenia awitan remaja meliputi sebagian kecil dari populasi pasien skizofrenia, namun memiliki derajat keparahan gejala yang lebih berat sehingga mempengaruhi kualitas hidup penderitanya. Salah satu instrumen yang dapat mengukur keparahan gejala skizofrenia adalah Positive and Negative Syndrome Scale (PANSS). Penelitian ini bertujuan untuk mengetahui karakteristik demografi dan membandingkan skor PANSS antara pasien skizofrenia awitan remaja dan awitan dewasa. Metode: Penelitian ini merupakan penelitian deskriptif dengan rancangan potong lintang yang dilakukan pada November 2019–Februari 2020. Penelitian ini menggunakan data sekunder dari rekam medik pasien skizofrenia yang dirawat di Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin tahun 2018 dengan metode total sampling dan menggunakan uji statistik Mann-Whitney U test.Hasil: Karakteristik demografi pasien skizofrenia awitan remaja mayoritas adalah laki-laki, berpendidikan sekolah menengah, tidak bekerja, dan belum menikah. Tidak ditemukan perbedaan antara skizofrenia awitan remaja dan awitan dewasa pada skala positif, skala negatif, skala psikopatologi umum, dan total skor PANSS. Namun demikian, ditemukan skizofrenia awitan remaja lebih besar daripada awitan dewasa dalam skor “isi pikiran yang tidak biasa” dalam PANSS skala psikopatologi umum (p=0,01).Kesimpulan: Tidak ada perbedaan Skor PANSS antara skizofrenia awitan remaja dan awitan dewasa. Namun demikian, ditemukan “isi pikiran yang tidak biasa” pada skala psikopatologi umum lebih berat pada skizofrenia awitan remaja.

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“…Very early-onset schizophrenia (VEOS) is a rare clinical entity that is associated with poor outcomes overall, particularly in securing effective and sustainable care plans for patients suffering from this condition, due to a lack of mental health services and child and adolescent psychiatrists [ 1 ]. The World Health Organization reported in 2017 that worldwide, the number of child psychiatrists is less than 0.1 per 100,000 children and adolescents in all income levels except for in high-income countries where the number reaches 1.19 per 100,000 [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Lack of Resources for Aftercare for Children With Psychosis: A System’s Failure

Shirk

Horn

Williams

et al. 2020

Cureus

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Very early-onset schizophrenia (VEOS) is a rare disorder that is associated with poor outcomes, especially with securing aftercare plans that will lead to stabilization of illness and prevent recidivism. There is a scarcity of resources available to patients with VEOS and their families once they leave inpatient treatment to achieve long-term success. Here we report a case of a 12-year-old-female who was diagnosed with VEOS at age 11 and since that diagnosis has struggled with finding appropriate resources to meet her needs, requiring frequent hospitalizations and displaying a continued decline in functioning.

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Early and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database

Cited by 43 publications

References 67 publications

A Neurodevelopment Approach for a Transitional Model of Early Onset Schizophrenia

A Neurodevelopment Approach for a Transitional Model of Early Onset Schizophrenia

Perbandingan Skor Positive and Negative Syndrome Scale Antara Skizofrenia Awitan Remaja dan Awitan Dewasa

Lack of Resources for Aftercare for Children With Psychosis: A System’s Failure

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