Clinical characteristics and outcomes of COVID-19 hospitalized patients with diabetes in the United Kingdom: A retrospective single centre study

Alkundi, Alamin; Mahmoud, Ibrahim; Musa, Abdelmajid; Naveed, Saima; Alshawwaf, Mohammed

doi:10.1530/endoabs.70.aep1051

Cited by 18 publications

(27 citation statements)

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“…Likewise, among the 4 patients described by Goldman [4], 2 patients died, and one patient remained in critical unit at the end of 30 days follow-up. Unexpectedly, in the series reported by Akundo et al [5] in UK, COVID-19 patients with DKA were more likely to survive (87.1%) compared with patients without DKA (50.6%) P = 0.046. The reasons of the latter finding are unclear, but may be related to differences in patients' characteristics, co-morbidities, and severity of COVID-19.…”

Section: Journal Of Clinical Research and Reportsmentioning

confidence: 86%

“…In one retrospective study from UK, 4 of 218 patients (1.8%) admitted with COVID-19 presented with DKA [4]. In another UK series, 8 of 232 patients (3.4%) with COVID-19 had DKA [5]. In one retrospective study from Wuhan, China, including 658 patients with COVID-19 admitted to the hospital, only 3 patients (0.45%) had DKA [6].…”

Section: Prevalence Of Hyperglycemic Crises In Covid-19mentioning

confidence: 99%

“…In one retrospective study from Wuhan, China, including 658 patients with COVID-19 admitted to the hospital, only 3 patients (0.45%) had DKA [6]. Therefore, available data suggests that prevalence of DKA associated with COVID-19 is not common and ranges from 0.45% to 3.4% [3][4][5][6].…”

Section: Prevalence Of Hyperglycemic Crises In Covid-19mentioning

confidence: 99%

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Hyperglycemic Crises in Patients with Covid-10

Mikhail¹

2020

JCRR

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Background: It is unclear whether the 2 hyperglycemic crises, diabetic ketoacidosis (DKA), and hyperosmolar hyperglycemic state (HHS) have different characteristics in patients with COVID-19. Objective: to describe prevalence, outcomes, and management of hyperglycemic crisis specifically in patients with COVID-19. Methods: English literature search of electronic databases supplemented by manual search up to July 31st, 2020. Search terms included hyperglycemic crises, diabetic ketoacidosis, COVID-19, ARDS, dexamethasone, mortality, safety. Since no randomized trials are available, all pertinent observational studies, case reports and major organization guidelines were reviewed. Results: DKA occurs in 0.45 to 3.4% of patients with COVID-19 admitted to the hospital, and results in approximately 50% mortality rate. Excessive intravenous hydration should be avoided in patients at risk or having acute respiratory distress syndrome (ARDS) to avoid volume overload. In patients presenting with hyperglycemic crisis and COVID-19 requiring oxygen or on mechanical ventilation, dexamethasone may be given after resolution of hyperglycemic crisis. Insulin doses need to be increased by 50-100% to control dexamethasone-induced hyperglycemia. Selected patients with non-complicated both DKA and COVID-19 may be safely managed by subcutaneous rapid-acting insulin in a step-down unit with blood glucose monitoring every 2 hours. This strategy may spare beds in the intensive care unit (ICU) and personal protective equipment (PPE), and decrease nursing time at bedside. Conclusions: Hyperglycemic crises with COVID-19 are uncommon but carry high mortality rate. Uncomplicated cases may be managed ia step-down unit. Dexamethasone can be given after resolution of hyperglycemic crisis.

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Section: Journal Of Clinical Research and Reportsmentioning

confidence: 86%

Section: Prevalence Of Hyperglycemic Crises In Covid-19mentioning

confidence: 99%

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Hyperglycemic Crises in Patients with Covid-10

Mikhail¹

2020

JCRR

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“…Some studies have shown that there is no significant relationship between mortality in patients with COVID-19 and diabetes and the most important cause of mortality in these patients was age [36,37]. Older people and people with underlying diseases are more likely to be infected with COVID-19 virus [38,39].…”

Section: Discussionmentioning

confidence: 99%

The effect of underlying diabetes disease on clinical outcome and survival in patients with Covid-19: a propensity score matching study

Ghadamgahi

Tapak

Bashirian

et al. 2021

J Diabetes Metab Disord

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“…10,11 Percebe-se que não foi o fato de estar internado em uma instituição pública ou privada que determinou o desfecho 'óbito' e sim as condições prévias à entrada no sistema de saúde, entre as quais as comorbidades associadas à COVID-19, como tabagismo, diabetes mellitus, hipertensão e obesidade, entre outras. 12,13 O tabagismo, por exemplo, enquanto um comportamento reconhecido como mais prevalente na população brasileira de baixa renda, 14 mostrou-se mais prevalente em indivíduos notificados por instituições públicas. É possível que o tabagismo contribua para uma pior evolução da COVID-19, uma vez que, além do dano pulmonar, o hábito de fumar está associado às doenças cardiovasculares, incluindo a predisposição para trombose.…”

Section: Discussionunclassified

Fatores associados ao óbito hospitalar por COVID-19 no Espírito Santo, 2020

Maciel

Jabor

Gonçalves

et al. 2020

Preprint

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Objetivo: Analisar os fatores associados ao óbito em indivíduos internados por COVID-19 em hospitais do Espírito Santo, Brasil. Métodos: Estudo transversal, com dados secundários. Modelos de regressão logística foram empregados para estimar razões de chance (odds ratio: OR) brutas e ajustadas. Resultados: Até 14 de maio de 2020, 200 indivíduos receberam alta e 220 foram a óbito. Do total de pessoas estudadas, 57,1% eram do sexo masculino, 46,4% maiores de 60 anos de idade, 57,9% foram notificados por instituição privada e 61,7% apresentaram mais de 1 comorbidade. Na análise ajustada, a mortalidade hospitalar foi maior entre aqueles nas faixas etárias de 51 a 60 (OR=4,33 -IC 95% 1,50;12,46) e mais de 60 anos (OR=11,84 -IC 95% 4,31;32,54), notificados por instituição pública (OR=8,23 -IC 95% 4,84;13,99) e com maior número de comorbidades (duas [OR=2,74 -IC 95% 1,40;5,34] e três [OR=2,90 -IC 95% 1,07;7,81]). Conclusão: Observa-se maior mortalidade em idosos, com comorbidades e usuários de hospitais públicos.

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Clinical characteristics and outcomes of COVID-19 hospitalized patients with diabetes in the United Kingdom: A retrospective single centre study

Cited by 18 publications

References 0 publications

Hyperglycemic Crises in Patients with Covid-10

Hyperglycemic Crises in Patients with Covid-10

The effect of underlying diabetes disease on clinical outcome and survival in patients with Covid-19: a propensity score matching study

Fatores associados ao óbito hospitalar por COVID-19 no Espírito Santo, 2020

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