Clinical characteristics and outcome in patients with antisynthetase syndrome associated interstitial lung disease: a retrospective cohort study

Jensen, M.L.; Løkke, Anders; Hilberg, Ole; Hyldgaard, Charlotte; Bendstrup, Elisabeth; Tran, Dan B.

doi:10.1080/20018525.2019.1583516

Cited by 18 publications

(18 citation statements)

References 21 publications

(31 reference statements)

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“…Characteristically, the lesions occur over the metacarpophalangeal and interphalangeal joints and more rarely in the elbows, knees, and/or feet [42]. Gottron's papules have been observed in about 50% of patients with ASS [43] and in up to 87% of patients with DM and are considered a pathognomonic sign of this disease [44,45].…”

Section: Gottron's Papules and Gottron's Signmentioning

confidence: 99%

Patients with Interstitial Lung Disease Secondary to Autoimmune Diseases: How to Recognize Them?

Sambataro

Pignataro³

et al. 2020

Diagnostics

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The diagnostic assessment of patients with Interstitial Lung Disease (ILD) can be challenging due to the large number of possible causes. Moreover, the diagnostic approach can be limited by the severity of the disease, which may not allow invasive exams. To overcome this issue, the referral centers for ILD organized Multidisciplinary Teams (MDTs), including physicians and experts in complementary discipline, to discuss the management of doubtful cases of ILD. MDT is currently considered the gold standard for ILD diagnosis, but it is not often simple to organize and, furthermore, rheumatologists are still not always included. In fact, even if rheumatologic conditions represent a common cause of ILD, they are sometimes difficult to recognize, considering the variegated clinical features and their association with all possible radiographic patterns of ILD. The first objective of this review is to describe the clinical, laboratory, and instrumental tests that can drive a diagnosis toward a possible rheumatic disease. The secondary objective is to propose a set of first-line tests to perform in all patients in order to recognize any possible rheumatic conditions underlying ILD.

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Section: Gottron's Papules and Gottron's Signmentioning

confidence: 99%

Patients with Interstitial Lung Disease Secondary to Autoimmune Diseases: How to Recognize Them?

Sambataro

Pignataro³

et al. 2020

Diagnostics

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“…For example, in a previous study of our research group, we reported that in our ASSD cohort, the most frequent HRCT pattern was OP, followed by NSIP (1). Conversely, other studies have shown that NSIP is the most frequent tomographic pattern (7,9,22). This finding could be due to differences in the sample size, different inclusion criteria, and distinct population characteristics.…”

Section: Discussionmentioning

confidence: 57%

Genetic Susceptibility to Antisynthetase Syndrome Associated With Single-Nucleotide Variants in the IL1B Gene That Lead Variation in IL-1β Serum Levels

et al. 2020

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The antisynthetase syndrome (ASSD) is an autoimmune disorder characterized by myositis, arthritis, mechanic's hands, fever, Raynaud phenomenon, and interstitial lung disease (ILD). We aimed to evaluate single-nucleotide polymorphisms in the interleukin 1B (IL1B) gene and their association between ILD with antisynthetase autoantibodies, as well as IL-1β serum levels. The most frequent antisynthetase autoantibody was anti-Jo1. The most frequent tomographic pattern was non-specific interstitial pneumonia, whereas in the anti-Jo1 subjects, it was organized pneumonia. Anti-Jo1 patients tend to have more significant arthritis, and Raynaud phenomenon have higher levels of creatinine phosphokinase. In the IL1B gene, the GG genotype and G allele of rs1143634 [odds ratio (OR) = 2.21 and OR = 2.60, respectively, p < 0.05] are associated with an increased risk, as well as with the dominant and recessive models (p < 0.05). This finding is maintained after logistic regression analysis adjusting for potential confounding variables (p < 0.05). Subjects with the rs16944/AG heterozygous genotype had higher serum levels of IL-1β compared to homozygous (p < 0.05). In conclusion, rs1143634 is associated with a higher risk of ASSD. Also, the GA genotype is associated with higher levels of IL-1β in ASSD patients.

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“…The antibody usually causes anti-synthetase syndrome, interstitial lung disease and myositis. 39,40,42,43 Anti-centromere and c-ANCA in ON have been occasionally reported in systemic sclerosis and granulomatosis with polyangiitis, respectively. 44,45 Idiopathic-ON had some special characteristics, such as severe visual loss, abnormal enhancement of the chiasm and tract, and involvement of the long segment of the optic nerve.…”

Section: Discussionmentioning

confidence: 99%

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

Vanikieti

Janyaprasert

Lueangram

et al. 2020

OPTH

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Purpose: To analyze the demographic patterns, clinical characteristics and etiologies of acute optic neuritis (ON). Methods: This retrospective observational study included patients with acute ON who presented to a university hospital in Bangkok, Thailand, between January 2010 and March 2020. The demographic details, clinical characteristics and etiologies of acute ON were evaluated. Results: A total of 171 patients were included in the study (78.4% [n=134] female; mean age 45 years [standard deviation 15.4 years]; 32.2% [n=55] bilateral involvement). The most common type of acute ON was idiopathic (51.5%), followed by neuromyelitis optica spectrum disorder (NMOSD, 30.9%), other autoimmune disorders (9.9%), myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD, 5.3%), multiple sclerosis (MS, 1.8%), and postinfection (0.6%). In the other autoimmune disorders group, 2 patients developed systemic lupus erythematosus (1.2%), 2 Sjogren's syndrome (1.2%), 1 RA (0.6%), 1 anti-NMDAR (0.6%), 3 anti-Jo1 (1.8%), 2 c-ANCA (1.2%), 1 anti-centromere (0.6%), and 5 nonspecific autoimmune disorders (2.9%). In the idiopathic group, 38.6% developed single isolated ON, 1.8% relapsing isolated ON and 11.1% chronic relapsing inflammatory optic neuropathy. Conclusion: The most common form of acute ON in this study, similar to other Asian countries, was idiopathic. Idiopathic-ON shared some phenotypes with NMOSD and MOGAD. We also reported patients with anti-NMDAR, anti-Jo1, c-ANCA and anti-centromere disorders. Improvements in antibody detection have widened the range of possible etiologies of acute ON. The study highlighted the important role of antibodies in creating effective treatments in the future.

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Clinical characteristics and outcome in patients with antisynthetase syndrome associated interstitial lung disease: a retrospective cohort study

Cited by 18 publications

References 21 publications

Patients with Interstitial Lung Disease Secondary to Autoimmune Diseases: How to Recognize Them?

Patients with Interstitial Lung Disease Secondary to Autoimmune Diseases: How to Recognize Them?

Genetic Susceptibility to Antisynthetase Syndrome Associated With Single-Nucleotide Variants in the IL1B Gene That Lead Variation in IL-1β Serum Levels

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

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