Clinical Characteristics and Frequency of the Hereditary Restless Legs Syndrome in a Population of 300 Patients

Restless leg syndrome as co-morbidity in type 2 diabetes mellitus

“…Diabetics in our study frequently described RLS symptoms as "urge to move", but only those with polyneuropathy described their symptoms as painful, burning or electric, as also suggested by Winkelmann et al 20 In diabetics RLS appeared as a long-term complication of diabetes, many years after T2DM onset. RLS causes unpleasant sensations causing severe difficulty in initiating and maintaining sleep in subjects, disrupting sleep.…”

Restless legs syndrome: a new entity of neuropathic pain? Treatment with prolonged release oxycodone/naloxone combination

“…1 The prevalence of pain in RLS patients has been very differently rated, ranging from 17% 9 to 80%. 10 A prevalence of about 60% seems reasonable, according to some studies with more robust methodological procedures. 3,8 It should be noted, however, that RLS typically presents as an intermittent condition.…”

“…Accordingly, it has been estimated that up to 80% of patients with RLS report that the sensations are sometimes painful. 10 As for descriptors of sensation associated with RLS, a recent study 8 showed that "burning" was the most frequent sensory discriminator in patients with painful RLS (44% of clinically examined RLS patients, and 37% of a larger sample of the French RLS Association). It is perplexing that the descriptor "burning" was not mentioned at all in other studies.…”

Restless Legs Syndrome

“…The mean age of onset fell from 51.5 years in the second generation to 19.8 years in the fourth generation. Winkelmann et al 25 analysed 300 patients from 16 families and found 42.3% of patients with idiopathic and 11.7% with uremic RLS as de®nite hereditary RLS. They also found that patients with familial RLS had their onset of symptoms at a younger age and signi®cant worsening of symptoms during pregnancy.…”