Clinical Characteristics and Bacteriological Profile of Moraxella Keratitis

Inoue, Hidenori; Suzuki, Takashi; Inoue, Tomoyuki; Hattori, Takaaki; Nejima, Ryohei; Todokoro, Daisuke; Hoshi, Saichi; Eguchi, Hiroshi; Miyamoto, Hitoshi; Ohashi, Yuichi

doi:10.1097/ico.0000000000000470

Cited by 35 publications

(38 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moraxella species on the other hand, are a rarer causative pathogen for keratitis with a reported rate of 3.0-3.9% of all cultured proven bacterial keratitis. 3,17 Inoue et al 18 reviewed 30 cases of Moraxella keratitis retrospectively and found that contact lens wear was one of the predisposing factors for this infection but other ocular comorbidities including the use of steroid eye drops and poor ocular surface were also significant contributing factors. When patient age was more than 60 years, systemic comorbidities, such as diabetes, were an important predisposing factor.…”

Section: Discussionmentioning

confidence: 99%

Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital

Tan

Walkden

et al. 2017

Eye

101

114

View full text Add to dashboard Cite

PurposeTo investigate the frequencies, trends, and in vitro drug susceptibilities of the causative pathogens in microbial keratitis in Manchester Royal Eye Hospital.Patients and methodsCorneal scrape results recorded by the microbiology service between 2004 and 2015 were extracted from an established database. A total of 4229 corneal scrape specimens were identified from an established database. First-line antibiotic treatment in our centre during the study period was ofloxacin and second line was cefuroxime and gentamicin.ResultsMean age was 45.9±21.0. A total of 1379 samples (32.6%) were culture positive. One hundred forty-eight (10.7%) specimens cultured multiple organisms. Of the 1539 organisms identified, 63.3% were Gram-positive bacteria, 27.3% Gram-negative bacteria, 7.1% fungi, and 2.3% Acanthamoebae. A decreasing trend in Gram-positive isolates was found together with a stable trend in Gram negatives and an increasing trend in Acanthamoeba and fungi. There appeared to be a significant increasing trend of Moraxella infection (P=0.001). In all, 83.1 and 90.8% of Gram-positive and -negative isolates tested were susceptible to ofloxacin, respectively. Cefuroxime covered 86.6% of Gram-positive and 61.4% of Gram-negative isolates, whereas gentamicin covered 88.8 and 96.5% of Gram-positive and -negative isolates, respectively.ConclusionWe found a change in the type of Gram-negative organisms isolated over time, with the Moraxella species on the rise. Reassuringly, no significant increase in resistance was observed in vitro for any of the commonly used antibiotics. Ofloxacin remains a good first-line antibiotic treatment but duo-therapy does have broader coverage and should be considered in non-responsive cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital

Tan

Walkden

et al. 2017

Eye

101

114

View full text Add to dashboard Cite

show abstract

“…As first described by Morax [1], the genus, Moraxella , appears to have a specific tropism as an ocular pathogen for keratitis [2,3,4,5], conjunctivitis [6], and endophthalmitis [7]. Moraxella keratitis appears to be on the rise based on recent reports [2,3,4,5,8]. Bacterial conjunctivitis is generally self-limiting, but Moraxella conjunctivitis can persist for weeks and presents as a follicular conjunctivitis which can be misdiagnosed as inclusion conjunctivitis due to Chlamydia [6,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Moraxella nonliquefaciens and M. osloensis Are Important Moraxella Species That Cause Ocular Infections

et al. 2019

View full text Add to dashboard Cite

Moraxella is an ocular bacterial pathogen isolated in cases of keratitis, conjunctivitis, and endophthalmitis. Gram-negative brick-shaped diplobacilli from ocular specimens, and slow growth in culture, are early indications of Moraxella ocular infection; however, identifying Moraxella to species can be complex and inconsistent. In this study, bacteria consistent with Moraxella were identified to species using: (1) DNA sequencing coupled with vancomycin susceptibility, (2) MALDI-TOF mass spectrometry, and (3) the Biolog ID system. Study samples consisted of nine ATCC Moraxella controls, 82 isolates from keratitis, 21 isolates from conjunctivitis, and 4 isolates from endophthalmitis. The ATCC controls were correctly identified. For keratitis, 66 (80.5%) were identified as M. nonliquefaciens, 7 (9.0%) as M. lacunata, 5 (6%) as M. osloensis, 2 (2.5%) as Acinetobacter lwoffii, 1 (1.0%) as M. bovis/nonliquefaciens, and 1 (1.0%) as M. osloensis/nonliquefaciens. For conjunctivitis, 9 (43.0%) were identified as M. osloensis, 6 (29.0%) as M. nonliquefaciens, 3 (14.3%) as Roseomonas, 2 (9.5%) as Acinetobacter (parvus, junii), and 1 (4.5%) as M. catarrhalis/nonliquefaciens. From endophthalmitis, 3 of 4 of the isolates were M. nonliquefaciens. Overall, M. nonliquefaciens and M. osloensis were identified in 70% (75 of 107) and 13% (14 of 107) of cases, respectively, totaling 83% (89 of 107). M. nonliquefaciens and M. osloensis are important bacterial pathogens of the eye as determined by DNA sequencing, MALDI-TOF MS, and Biolog. Although Moraxella catarrhalis is a clinical pathogen, other species of Moraxella appear to have a prominent role in eye infections.

show abstract

“…Tan et al [1] recently reported a 12-year analysis of microbial keratitis in a tertiary eye centre (Manchester) in which they found a significant decreasing trend in Gram-positive keratitis along with an increasing trend in Moraxella keratitis. According to the literature and our experience, Moraxella keratitis is known for its chronicity and slow response to treatment [2,3]. In view of their findings, we performed a 10year retrospective analysis (January 2008-December 2017) on the microbiological profiles of microbial keratitis in Sunderland Eye Infirmary (one of the three main eye centres in the North East of England) to determine if the changing trend of microbial keratitis was similar across the UK.…”

mentioning

confidence: 99%