Clinical characteristics and antibiotic resistance of Shigella gastroenteritis in Ankara, Turkey between 2003 and 2009, and comparison with previous reports

Özmert, Elif Nursel; Ince, Osman Tolga; Örün, Emel; Yalçın, S. Songül; Yurdakök, Kadriye; Gür, Deniz

doi:10.1016/j.ijid.2011.08.008

Cited by 30 publications

(27 citation statements)

References 21 publications

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“…Another related reason might be that much fewer patients with diarrhea desired to go to the hospital, which decreased the chances of acquiring lethal SARS infections. Another important finding was that S. sonnei replaced S. flexneri to become the predominant subgroup causing shigellosis in the Beijing area, which was similar to the trends and patterns reported in industrialized countries (Bonfiglio et al, 2002;Ekdahl and Andersson, 2005;Filliol-Toutain et al, 2011;Gupta et al, 2004;Ozmert et al, 2011).…”

Section: Discussionsupporting

confidence: 78%

Genotypes and antimicrobial profiles of Shigella sonnei isolates from diarrheal patients circulating in Beijing between 2002 and 2007

Bao

Chen

et al. 2012

Diagnostic Microbiology and Infectious Disease

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Shigella sonnei has become the dominant serotype causing shigellosis in Asian countries in recent years. In this study, we characterize the increasing trend of antibiotic resistance profiles and genotypes of S. sonnei isolates in the Beijing area. From January 2002 to December 2007, a total of 1108 Shigella isolates including 362 S. sonnei were recovered from diarrhea patients at the 302nd Hospital in Beijing. While the frequency of S. flexneri gradually decreased, S. sonnei gradually increased and became the dominant species. A total of 362 S. sonnei isolates were further analyzed for their antimicrobial profiles and 272 revived isolates were selected for genotyping analysis, respectively. High-level antimicrobial resistances were observed in sulfamethoxazole/trimethoprim (94.5%), ampicillin (40.3%), piperacillin (36.5%), and ceftriaxone (12.8%) with significant single- and multiple-drug resistance increase trends from 2002 to 2007 (P = 0.0000). Pulsed-field gel electrophoresis analysis indicated that 263 (96.7%) S. sonnei belonged to 1 clonal genotype A, which were further divided into A1-A6 subtypes. While subtype A2 was dominant in the early stage of study years, subtype A4 started to emerge and increased significantly in later years. Antimicrobial resistance rates are statistically different among the 6 subtypes (P = 0.0000), and A4 possessed the highest resistance rates to ampicillin (83.7%) and piperacillin (81.4%). Subtype A3 was highly clustered in inpatients compared to other subtypes (P = 0.0145). This study indicates that a clonal S. sonnei strain has become dominant in the Beijing area, and subtype A4 is responsible for increased antibiotic resistance.

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Section: Discussionsupporting

confidence: 78%

Genotypes and antimicrobial profiles of Shigella sonnei isolates from diarrheal patients circulating in Beijing between 2002 and 2007

Bao

Chen

et al. 2012

Diagnostic Microbiology and Infectious Disease

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“…In recent years, antimicrobial resistant Shigella strains have been commonly identified, threatening and complicating effective treatment of bacillary dysentery. Our study shows that Shigella isolated in China tend to have a higher resistance to nalidixic acid, ampicillin, tetracycline, and sulfamethoxazole than that found in many other countries [38, 39]. These antibiotics were previously used as first-line treatments and are still commonly prescribed to treat bacillary dysentery.…”

Section: Discussionmentioning

confidence: 74%

The changing epidemiology of bacillary dysentery and characteristics of antimicrobial resistance of Shigella isolated in China from 2004–2014

Chang

Zhang

et al. 2016

BMC Infect Dis

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BackgroundBacillary dysentery caused by bacteria of the genus Shigella is a significant public health problem in developing countries such as China. The objective of this study was to analyze the epidemiological pattern of bacillary dysentery, the diversity of the causative agent, and the antimicrobial resistance patterns of Shigella spp. for the purpose of determining the most effective allocation of resources and prioritization of interventions.MethodsSurveillance data were acquired from the National Infectious Disease Information Reporting System (2004–2014) and from the sentinel hospital-based surveillance system (2005–2014). We analyzed the spatial and temporal distribution of bacillary dysentery, age and sex distribution, species diversity, and antimicrobial resistance patterns of Shigella spp.ResultsThe surveillance registry included over 3 million probable cases of bacillary dysentery during the period 2004–2014. The annual incidence rate of bacillary dysentery decreased from 38.03 cases per 100,000 person-years in 2004 to 11.24 cases per 100,000 person-years in 2014. The case-fatality rate decreased from 0.028% in 2004 to 0.003% in 2014. Children aged <1 year and 1–4 years were most affected, with higher incidence rates (228.59 cases per 100,000 person-years and 92.58 cases per 100,000 person-years respectively). The annual epidemic season occurred between June and September. A higher incidence rate of bacillary dysentery was found in the Northwest region, Beijing and Tianjin during the study period. Shigella flexneri was the most prevalent species that caused bacillary dysentery in China (63.86%), followed by Shigella sonnei (34.89%). Shigella isolates were highly resistant to nalidixic acid (89.13%), ampicillin (88.90%), tetracycline (88.43%), and sulfamethoxazole (82.92%). During the study period, isolates resistant to ciprofloxacin and cefotaxime increased from 8.53 and 7.87% in 2005 to 44.65 and 29.94% in 2014, respectively.ConclusionsThe incidence rate of bacillary dysentery has undergone an obvious decrease from 2004 to 2014. Priority interventions should be delivered to populations in northwest China and to individuals aged <5 years. Antimicrobial resistance of Shigella is a serious public health problem and it is important to consider the susceptibility profile of isolates before determining treatment.

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“…A possible limitation of this study could be that the numbers of S. dysenteriae and S. boydii, isolated in the area of Amsterdam, are relative low. Low incidence of S. dysenteriae and S. boydii is seen in throughout the world (Kotloff et al, 1999;von Seidlein et al, 2006;Zaidi et al, 2013;Ozmert et al, 2011;Sivapalasingam et al, 2006). The prevalence of S. flexneri, S. sonnei, S. boydii, and S. dysenteriae were 60%, 15%, 6%, and 6% in developing countries; and 16%, 77%, 2%, and 1% in industrialized countries, respectively (Kotloff et al, 1999), indicating that the distribution of the strains included in the study is similar to the distribution of Shigella species in the (industrialized) world.…”

Section: Discussionmentioning

confidence: 99%

Rapid and reliable discrimination between Shigella species and Escherichia coli using MALDI-TOF mass spectrometry

Paauw¹,

Jonker

Roeselers³

et al. 2015

International Journal of Medical Microbiology

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Clinical characteristics and antibiotic resistance of Shigella gastroenteritis in Ankara, Turkey between 2003 and 2009, and comparison with previous reports

Cited by 30 publications

References 21 publications

Genotypes and antimicrobial profiles of Shigella sonnei isolates from diarrheal patients circulating in Beijing between 2002 and 2007

Genotypes and antimicrobial profiles of Shigella sonnei isolates from diarrheal patients circulating in Beijing between 2002 and 2007

The changing epidemiology of bacillary dysentery and characteristics of antimicrobial resistance of Shigella isolated in China from 2004–2014

Rapid and reliable discrimination between Shigella species and Escherichia coli using MALDI-TOF mass spectrometry

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