Clinical Case Notes

Abstract

Meningococcal C conjugate vaccines have proved to be safe and highly efficient in preventing group C meningococcal disease. Very few serious side‐effects have been reported. The case is reported of a 14 year‐old boy who developed acute posterior multifocal placoid pigment epitheliopathy 3 days after receiving the vaccine. No other cause of uveitis was detected from history or from investigations. The patient was treated with topical and systemic corticosteroids and his visual acuity improved to near normal in both eyes at 4 months. Meningococcal immunization may have precipitated acute posterior multifocal placoid pigment epitheliopathy in this adolescent.

Acute idiopathic blind spot enlargement syndrome following measles, mumps and rubella vaccination

“…9,11À13 It presents bilaterally in young adults of any gender with asymmetric visual loss associated with photopsia or scotoma. 9,11,13 It may present with a flu-like prodrome. 10,12 Fundus examination reveals placoid lesions, usually less than one disc diameter and located mainly in the posterior pole.…”

Acute posterior multifocal placoid pigment epitheliopathy and granulomatous uveitis following influenza vaccination

“…Although it usually occurs in otherwise healthy young adults, it may occur in association with severe systemic disorders, including tuberculosis, 2 Wegener's granulomatosis, 3 cerebral vasculitis, 4 Lyme disease, 5 and sarcoidosis. 6 In addition, it rarely occurs following vaccination for hepatitis B virus, 7 meningococcus C, 8 varicella zoster virus, 9 and influenza virus. 10 …”

Editor's quiz: GI snapshot

“…APMPPE has been well documented following vaccinations, including the swine flu vaccine, hepatitis B vaccine and meningococcal C conjugate vaccine 2 3. To the best of our knowledge, APMPPE has not been reported following Varivax, a live attenuated varicella virus vaccination.…”