Amine Oxidases and Their Impact on Neurobiology 1990
DOI: 10.1007/978-3-7091-9113-2_28
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Clinical, biochemical and psychometric findings with the new MAO-A-inhibitors moclobemide and brofaromine in patients with major depressive disorder

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Cited by 7 publications
(8 citation statements)
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“…During the 1980s, controlled studies provided evidence that MAOIs are very effective in the treatment of so-called therapy-resistant depressions, atypical depressions, phobias, panic disorders and anxiety states (3,4). In addition, factors such as low cardiotoxicity, absence of anticholinergic side-effects and mood-activating properties may represent advantages of MAOIs over tricyclic antidepressants (5).…”
Section: Introductionmentioning
confidence: 99%
“…During the 1980s, controlled studies provided evidence that MAOIs are very effective in the treatment of so-called therapy-resistant depressions, atypical depressions, phobias, panic disorders and anxiety states (3,4). In addition, factors such as low cardiotoxicity, absence of anticholinergic side-effects and mood-activating properties may represent advantages of MAOIs over tricyclic antidepressants (5).…”
Section: Introductionmentioning
confidence: 99%
“…Monoamine oxidase inhibitors (MAOIs) are mainly used in psychiatry for the treatment of depressive and anxiety disorders and in neurology for the treatment of Parkinson's disease and Alzheimer's disease [1][2][3] . Honey, pollen and propolis are all natural bee products, new therapeutic characteristics of which are emerging every day.…”
Section: Introductionmentioning
confidence: 99%
“…When considering efficacy, there is now ample evidence to show that the reversible MAOA inhibitors are effective antidepressants and are as efficacious as the tricyclic reuptake inhibitors (eg see Laux et al, 1989;Kissling et al, 1989;Moller et al, 1989). Since the irreversible MAOIs were often administered at doses below the therapeutic threshold because of the risk of adverse side-effects, the reversible MAOA inhibitors can be generally regarded as more efficacious in real terms than the first generation drugs.…”
Section: Monoamine Oxidase Inhibitorsmentioning
confidence: 99%
“…Consequently, the second generation MAOIs may provide a genuine alternative for patients who do not improve when receiving monoamine reuptake inhibitors. The only question concerning the efficacy of the reversible MAOA inhibitors is whether the effect is maintained after long-term treatment (Laux et al, 1989;Udabe et al, 1989) and this issue needs to be meaningfully resolved.…”
Section: Monoamine Oxidase Inhibitorsmentioning
confidence: 99%