Clinical association between non‐alcoholic fatty liver disease and the development of hypertension

Ryoo, Jae‐Hong; Suh, Young Ju; Shin, Ho Cheol; Cho, Yong Kyun; Choi, Joong-Myung; Park, Sung Keun

doi:10.1111/jgh.12643

Cited by 107 publications

(81 citation statements)

References 38 publications

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“…In a large occupational cohort of Korean men, baseline NAFLD was prospectively associated with incident hypertension [27]. Another study of this Korean cohort, including both men and women, also showed that NAFLD was associated with the new onset of hypertension [28].…”

Section: Discussionmentioning

confidence: 99%

Bi-directional analysis between fatty liver and cardiovascular disease risk factors

Hwang

Pedley

et al. 2017

Journal of Hepatology

180

145

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Background & Aims The relations of non-alcoholic fatty liver disease to cardiovascular disease (CVD) risk factors are not fully understood. The objective of our study is to explore the bi-directional relationships of fatty liver to CVD risk factors. Methods We prospectively evaluated whether liver fat predicted the development of CVD risk factors and whether CVD risk factors predicted new onset fatty liver during 6 years of follow up in middle- to older-aged Framingham Heart Study participants. We estimated liver fat using multi-detector computed tomography. Results We included 1,051 participants (mean age 45 ± 6 years, 46% women). The prevalence of fatty liver was 18% at baseline. In participants without fatty liver at baseline, 101 participants developed incident fatty liver over approximately 6 years. Baseline liver fat (per standard deviation increase) was associated with increased odds of incident hypertension (OR 1.42; 95% CI 1.15-1.76; p=0.001) and incident type 2 diabetes (OR 1.43; 95% CI 1.09-1.88, p<0.001). In a parallel analysis, individuals with hypertension (OR 3.34; 95% CI 2.04-5.49), hypertriglyceridemia (OR 3.04; 95% CI:1.84-5.02), impaired fasting glucose (OR 2.92; 95% CI 1.76-4.82), or type 2 diabetes (OR 4.15; 95% CI 1.19-14.46) at baseline had higher odds of incident fatty liver compared to individuals without those conditions (all p<0.03). In both analyses, the observed associations remained similar after additional adjustments for measures of adiposity. Conclusions The present study demonstrated bi-directional relationships between fatty liver and CVD risk factors among middle- to older-aged Framingham Heart Study participants.

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Section: Discussionmentioning

confidence: 99%

Bi-directional analysis between fatty liver and cardiovascular disease risk factors

Hwang

Pedley

et al. 2017

Journal of Hepatology

180

145

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“…Supporting a dose-response relationship, the investigators reported that hypertension was particularly common in those who had moderate-to-severe NAFLD at baseline. 93 So closely are increased serum uric acid (SUA) levels associated with other features of the MetS [94][95][96][97][98] that they can be considered an additional feature of the MetS. There is a graded, positive association between SUA levels and NAFLD severity and elevated SUA levels predict NAFLD risk independently of coexisting MetS features in different ethnicities.…”

Section: Metabolic Syndromementioning

confidence: 99%

“…A recent retrospective cohort study conducted in 11,448 South Korean people without hypertension at baseline elegantly supports the notion that development of new or resolution of pre-existing fatty liver over 5 years strongly affects the risk of incident hypertension 92 . Another large prospective cohort study has shown that the risk of developing hypertension increased substantially in those with NAFLD and the risk, although attenuated, remained significant after adjustment for covariates 93 . Supporting a dose-response relationship, the investigators reported that hypertension was particularly common in those who had moderate-to-severe NAFLD at baseline.…”

Section: Metabolic Syndromementioning

confidence: 99%

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Lonardo

Bellentani

Argo

et al. 2015

Digestive and Liver Disease

400

318

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We aimed to illustrate the epidemiology of nonalcoholic fatty liver disease in high-risk groups, which were identified based on existing literature. To this end, PubMed was searched to retrieve original articles published through May 2015 using relevant and pertinent keywords "nonalcoholic fatty liver disease" and "diabetes", "obesity", "hyperlipidemia", "familial heterozygous hypobelipoproteinemia", "hypertension", "metabolic syndrome", "ethnicity", "family history" or "genetic polymorphisms".We found that age, sex and ethnicity are major physiologic modifiers of the risk of nonalcoholic fatty liver disease, along with belonging to "nonalcoholic fatty liver disease families" and carrying risk alleles for selected genetic polymorphisms. Metabolic syndrome, diabetes, obesity, mixed hyperlipidaemia and hypocholesterolemia due to familial hypobetalipoproteinaemia are the major metabolic modifiers of nonalcoholic fatty liver disease risk. Compared to these metabolic conditions, however, arterial hypertension appears to carry a relatively more modest risk of nonalcoholic fatty liver disease.A better understanding of the epidemiology of nonalcoholic fatty liver disease may result in a more liberal policy of case finding among high-risk groups.

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“…Furthermore, several studies have shown that HTN was independently associated with non‐alcoholic fatty liver disease , which is a major risk factor for chronic liver disease worldwide . Patients with non‐alcoholic fatty liver disease might progress to cirrhosis, fibrosis and liver failure, which can subsequently result in poor graft function .…”

Section: Discussionmentioning

confidence: 99%

Survival rates after liver transplantation using hypertensive donor grafts: an analysis of the Scientific Registry of Transplant Recipients database

Mei

Xiang

et al. 2017

J Hepato Biliary Pancreat

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Clinical association between non‐alcoholic fatty liver disease and the development of hypertension

Abstract: Development of hypertension is more potentially associated with the more progressive NAFLD than normal or milder state. In addition, NAFLD was an independent risk factor for hypertension.

Cited by 107 publications

References 38 publications

Bi-directional analysis between fatty liver and cardiovascular disease risk factors

Bi-directional analysis between fatty liver and cardiovascular disease risk factors

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Survival rates after liver transplantation using hypertensive donor grafts: an analysis of the Scientific Registry of Transplant Recipients database

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