Survival rates after liver transplantation using hypertensive donor grafts: an analysis of the Scientific Registry of Transplant Recipients database

Hu, Zhenhua; Mei, Shengmin; Xiang, Jie; Zhou, Jié; Li, Zhiwei; Zhou, Lin; Yan, Sheng; Wang, Weilin; Zheng, Shusen

doi:10.1002/jhbp.466

Cited by 2 publications

(2 citation statements)

References 30 publications

(26 reference statements)

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“…In comparison, Hu et al . [ 33 ] reported a much lower 5-year survival rate of 39.2% among postliver transplant patients. This discrepancy in findings may once again be due to age differences between cohorts.…”

Section: Discussionmentioning

confidence: 99%

Predictors of survival among patients with chronic hepatitis C at a tertiary care center in Oman

Al-Shuaili,

Al-Busafi,

Al-Naamani

et al. 2023

Saudi Journal of Gastroenterology

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Background: Chronic hepatitis C (CHC) is a leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. This study aimed to determine rates and predictors of survival among Omani patients with CHC at a tertiary hospital in Muscat, Oman. Methods: This ambidirectional cohort study included all CHC patients who presented to the Sultan Qaboos University Hospital between January 2009 and December 2017. Baseline demographic, clinical, laboratory, and radiological data were analyzed. Patients were followed-up until death or the endpoint of the study (April 2022) to determine survival and associations with other parameters. Results: A total of 702 CHC patients were included, of which 398 (56.7%) were under 50 years of age and 477 (67.9%) were male. Overall, 180 patients (25.6%) died by the study endpoint. The mean duration of follow-up was 93.3 ± 48.0 months. The 5-year survival rate was estimated to be 80.5%, while the 10-year survival was 73%. Sustained virological response and the absence of diabetes mellitus, chronic kidney disease, HCC, or other malignancies were associated with significantly better overall survival. The 3- and 5-year survival rate of patients with hepatitis C virus (HCV)-related HCC was 46.5% and 27.6%, respectively, with a median survival of 29.5 months. Co-infection with hepatitis B was associated with poor survival among this subgroup; conversely, early HCV screening and the presence of a single HCC lesion were associated with better overall survival. Conclusions: National policies for early CHC screening and rapid treatment are needed to improve survival rates in this population.

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Section: Discussionmentioning

confidence: 99%

Predictors of survival among patients with chronic hepatitis C at a tertiary care center in Oman

Al-Shuaili,

Al-Busafi,

Al-Naamani

et al. 2023

Saudi Journal of Gastroenterology

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“…Alamo et al [ 13 ] found donor hypertension was suggestive of poor prognostic factors in liver transplant recipient survival. Recently, in an analysis of the SRTR database, Hu et al [ 25 ] found that liver transplant recipients of HTN donor grafts have poorer graft and patient survival than those of non-HTN donor grafts. However, in the present study, we found that having a donor with hypertension is not a poor prognostic factor for patient survival and liver graft survival in SLKT recipients.…”

Section: Discussionmentioning

confidence: 99%

Receiving Hypertensive Donor Grafts Is Associated with Inferior Prognosis in Simultaneous Liver-Kidney Transplantation Recipients

et al. 2018

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BackgroundThe impact of hypertensive (HTN) donor grafts on the prognosis of simultaneous liver-kidney transplantation (SLKT) patient is not known, and an applicable risk scoring system for SLKT patient survival is lacking. This study aimed to evaluate the impact of donor HTN on patient survival of SLKT recipients and to identify independent risk factors.Material/MethodsData from 3844 adult SLKT recipients receiving deceased donor grafts from March 2002 to December 2014 in the Scientific Registry of Transplant Recipients (SRTR) database were retrospectively analyzed. Kaplan-Meier analysis was used to compare patient and graft survival. Multivariate Cox proportional hazard models were built to identify independent risk factors associated with patient and graft survival.ResultsSLKT patients receiving HTN donor grafts had significantly shorter 5-year patient survival and kidney graft survival rates than did those receiving non-HTN donor grafts (50.1% vs. 63.2%, p<0.0001 and 45.4% vs. 67.8%, p<0.0001, respectively). Multivariate analysis identified HTN donor, donor age, donation after cardiac death, cold ischemia time, recipient age, recipient condition at transplant, recipient hepatitis C infection, need for life support, and recipient pre-transplant albumin level as independent risk factors associated with inferior patient survival in SLKT recipients. A risk scoring model that predicted excellent stratification of prognostic subgroups was established (AUC, 0.762; 95% CI, 0.739–0.785).ConclusionsAn SLKT patient receiving a graft from an HTN donor has an inferior prognosis. A risk scoring system applicable to patient survival in SLKT recipients was developed.

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Survival rates after liver transplantation using hypertensive donor grafts: an analysis of the Scientific Registry of Transplant Recipients database

Abstract: The present study shows that graft and patient survivals were lower in recipients of hypertensive donor grafts, and highlights the importance of appropriately screening donors for HTN.

Cited by 2 publications

References 30 publications

Predictors of survival among patients with chronic hepatitis C at a tertiary care center in Oman

Predictors of survival among patients with chronic hepatitis C at a tertiary care center in Oman

Receiving Hypertensive Donor Grafts Is Associated with Inferior Prognosis in Simultaneous Liver-Kidney Transplantation Recipients

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