Clinical aspects of supportive perfusion

Ak, Yates

doi:10.1002/bjs.1800541323

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1971

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“…In a large number of publications the notion that partial bypass of the left ventricle is likely to reduce left ventricular work has been challenged (Small, 1967). If work of the ventricle is related to the tension time index almost entirely, there can be no reduction in cardiac work without a lowering of systemic pressure (Yates, 1967).…”

Section: Discussionmentioning

confidence: 99%

Prolonged partial left heart bypass in sheep: successful use of a new type of pump

Temple

Ritchie

Wright

et al. 1971

Thorax

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A method of partial left heart bypass is described. A non-pulsatile atraumatic pump capable of handling 2 to 4 litres of blood a minute has been developed and tested. It lends itself to easy adjustment to meet changes in left atrial and systemic pressures and can function for many hours without adjustment. Partial left heart bypass for 24 hours was carried out on sheep. No damage to the blood resulted from its use and air em(bolism was completely excluded. Initial difficulties associated with 24 hours' anaesthesia were solved by maintaining the animal erect in a cage. In the last series of experiments only one out of 11 sheep had an unexplained death that could have been associated with bypass. The equipment appears to be suitable for clinical trial.

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Section: Discussionmentioning

confidence: 99%