Clinical aspects of rheumatoid arthritis

Khurana, Rohit; Berney, S.M.

doi:10.1016/j.pathophys.2005.07.009

Cited by 70 publications

(56 citation statements)

References 53 publications

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“…Rheumatoid arthritis (RA) is a very common autoimmune disease which affects 1-1.5% of the world population, with high prevalence in women 1,2 . nevertheless, it can occur at any age, with more frequent beginning in adults aged 40-60 years 1 .…”

Section: Introductionmentioning

confidence: 99%

“…nevertheless, it can occur at any age, with more frequent beginning in adults aged 40-60 years 1 . RA i a chronic disorder, systemic and of unknown etiology, marked by inflammatory alterations in the synovial membrane (synovitis) and in the articular structures, characterized by the development of autoantibodies and by the presence of pannus -a granulation tissue made in the synovia by proliferation of fibroblasts and inflammatory cells which invade and destroy the structures close to the articulation, such as the articular cartilage, the subchondral bone, the tendons and the ligaments 3 .…”

Section: Introductionmentioning

confidence: 99%

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Evidências de que um protocolo de atividade física pode reduzir a contagem de leucócitos sinoviais de ratos artríticos

Gomes

Bressan

Silva

et al. 2013

Rev Bras Med Esporte

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ABSTRACTintroduction: physical activity is thought to be beneficial to arthritis, delaying disability and/or improving joint function. in vivo studies using experimental models of arthritis may provide useful information about such benefits. Objective: The aim of the present study was to evaluate the effects of the low-intensity exercise on a model of CFA-induced arthritis in rats. Methods: Articular incapacitation was measured by the paw elevation time in 1-min periods of stimulated walk. Edema was evaluated by the knee-joint diameter. Synovial exudate was sampled after 10 days for leukocyte count. The exercise protocol consisted of a 2-min period of stimulated walk in the 1st day, 10 min in the 2nd day, and 20 min from the 3rd to the 10th day; The control animals were submitted to 1-min period of stimulated walk once a day over 10 days. Corticosteroid involvement was assessed by treating the animals with aminoglutethimide. Results: The exercise protocol produced a slight but sustained reduction of disability and joint swelling associated with a large reduction in the synovial leukocyte count. Aminoglutethimide only prevented the effect on synovial leukocyte count. Conclusion: These results suggest that a low-intensity physical activity does not aggravate the symptoms of arthritic animals, in fact showing a slight improvement, and still can markedly reduce the migration of leukocytes into the synovial space.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidências de que um protocolo de atividade física pode reduzir a contagem de leucócitos sinoviais de ratos artríticos

Gomes

Bressan

Silva

et al. 2013

Rev Bras Med Esporte

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“…The fact that RF might be positive in healthy individuals and that it might be in high levels in other rheumatoid disorders have led to the search for new autoantibodies. As a result, in recent years, there has been an increase in the search for possible tests, which might give new insights about the early diagnosis and prognosis of RA [12][13][14][15][16] . Anti-RA33 was the first identified autoantibody in distinguishing early phases of RA from other forms of arthritis and rheumatoid disorders.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of the anti-RA33 level in patients with rheumatoid arthritis

Türkmen

Hayta²,

Elden³

et al. 2016

Cumhuriyet Medical Journal

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The early diagnosis of Rheumatoid Arthritis (RA) is of due significance for the prevention of possible damage to the joint tissue by means of treatment. Laboratory tests are very important for monitoring RA activity and for the evaluation of the patients' response to the treatment. Rheumatoid factor, so far the most commonly used test for the cases with suspected RA, is not a specific parameter despite its sensitivity to RA. The measurement of other autoantibodies might be helpful to the diagnosis particularly for the cases with low RF titer or with suspected diagnosis. The measurement of anti-RA33 autoantibodies is one of the tests used in the diagnosis of the RA cases. The present study was conducted to compare anti-RA33 levels of healthy individuals with long-term RA cases and to evaluate the value of anti-RA33 test for the RA diagnosis. Method: Total 40 patients (28 female and 12 male) identified with RA at least for the last five years according to the classification criteria of American College of Rheumatology (ACR) reviewed in 1987 and 40 healthy controls included in the present study. Results: AntiRA-33 level was determined as 12.47±4.97 U/mL for the patients with RA and as 1.96±1.82 U/mL for the healthy controls, and there is no statistically significant difference between the groups. Conclusions: As a result AntiRA-33 level was evaluated in RA patients and no difference was found compared to control group.

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“…RA can be observed in all age groups with a peak incidence at 40-60 years of age. Genetic and environmental factors have been implied in the etiology [1,2]. Ankylosing spondylitis (AS) is a chronic inflammatory illness that particularly affected the spine, enthesis areas and the peripheral joints.…”

Section: Introductionmentioning

confidence: 99%

Association of Vitamin D with Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis

2015

Ann Clin Anal Med

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ÖzetAmaç: Vitamin D eksikliğinin, romatoid artrit (RA) ve ankilozan spondilit (AS) gibi otoimmun hastalıklarda başlatıcı bir neden mi yoksa hastalık aktivitesiyle ilişkili mi olduğu hala merak edilen bir konudur. Çalışmamızın amacı, Th1 baskın hastalıklardan olan RA ve AS hastalarında serum vitamin D seviyeleri ile hastalık aktiviteleri arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntem: Çalışmamız, retrospektif olarak 92 RA'li hasta, 100 AS'li hasta ve 62 sağlıklı kontrolün dosyalarından elde edilmiş bilgileri içermektedir. Çalışmaya alınan-ların yaşı, cinsiyeti, hastalık süreleri, kullandığı ilaçlar, vitamin D seviyeleri, kalsiyum, C-reaktif protein (CRP) ve eritrosit sedimentasyon hızı (ESH) değer-leri kayıt edildi. Hastalık aktiviteleri RA'li hastalarda hastalık aktivite skoru-28 (DAS28) ile, AS'li hastalarda ise bath ankilozan spondilit hastalık aktivite indeksi (BASDAİ) ile değerlendirildi. Bulgular: Vitamin D seviyeleri tüm gruplarda düşüktü. AS hastalarında, vitamin D seviyeleri ile BASDAİ, ESH ve CRP arasında istatiksel olarak negatif korelasyon yoktu (sırasıyla, r=-0.059, p=0.560, r=-0.072, p=0.473, r=-0.112, p=0.268). RA'li hastalarda ise vitamin D düze-yi ile DAS28 arasında anlamlı negatif korelasyon yoktu (r=-0.090, p=0.392). Tartışma: Çalışmamızda, tüm gruplarda vitamin D seviyeleri düşük bulundu ve bu vitamin D eksikliğinin, RA ve AS'in etyolojisinden ziyade hastalık aktivitesi ile ilişkili olabileceğini akla getirmektedir. Anahtar KelimelerVitamin D; Romatoid Artrit; Ankilozan Spondilit; Hastalık Aktivitesi Abstract Aim: Vitamin D deficiency in autoimmune disorders such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS), whether an initiator cause or associated with disease activity is still wondered. The aim of our study is to investigate the association between serum vitamin D levels and disease activity in subjects with RA and AS which are known to be Th1 dominant diseases. Material and Method: The study included the data of 92 patients with RA, 100 patients with AS and 62 healthy controls, which were retrospectively obtained from the patient files. The age, gender, duration of the disease, medications, levels of vitamin D, calcium, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were recorded. Disease activities were evaluated by Disease Activity Score-28 (DAS28) in patients with RA and Bath Ankylosing Spondylitis Disease Index (BASDAI) in patients with AS. Results: Vitamin D levels were low in all groups. In AS patients, there was no statistical negative correlation among vitamin D levels and BASDAI, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) (r=-0.059, p=0.560, r=-0.072, p=0.473, r=-0.112, p=0.268, respectively). In RA patients, there was also no significant negative correlation between vitamin D levels and DAS28 (r=-0.090, p=0.392). Discussion: In our study, low serum vitamin D levels were found in all groups, and it is suggested that vitamin D deficiency may be associated with the disease activity rather than the etiology of RA and ...

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Clinical aspects of rheumatoid arthritis

Cited by 70 publications

References 53 publications

Evidências de que um protocolo de atividade física pode reduzir a contagem de leucócitos sinoviais de ratos artríticos

Evidências de que um protocolo de atividade física pode reduzir a contagem de leucócitos sinoviais de ratos artríticos

The clinical significance of the anti-RA33 level in patients with rheumatoid arthritis

Association of Vitamin D with Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis

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