Clinical aspects and self-reported symptoms of sequelae of Yersinia enterocolitica infections in a population-based study, Germany 2009–2010

Rosner, Bettina; Werber, Dirk; Höhle, Michael; Stark, Klaus

doi:10.1186/1471-2334-13-236

Cited by 53 publications

(50 citation statements)

References 34 publications

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“…The two most common sequelae of Y. enterocolitica infection are reactive arthritis and erythema nodosum, an immunologically mediated disease resulting in inflammation of subcutaneous adipose tissue with eruption of painful nodular lesions (205). In one large study of 571 patients, 7% and 3% of 571 patients reported reactive arthritis or erythema nodosum, respectively (205).…”

Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

“…In one large study of 571 patients, 7% and 3% of 571 patients reported reactive arthritis or erythema nodosum, respectively (205). The onset of reactive arthritis generally occurs Ͻ3 weeks after enteritis, and the longer the duration of gastrointestinal symptoms, the greater the likelihood that reactive arthritis will develop (161).…”

Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

“…Bloody stools occur in 20 to 46% of cases, and host susceptibility, number of ingested organisms, and serotype are determining factors for severity of disease (201). Severe cases may require hospitalization due to dehydration; in one study, 27% of 571 patients were hospitalized (205).…”

Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

“…enterocolitica gastrointestinal disease ranges from self-limiting enteritis with diarrhea, low-grade fever, and abdominal pain to severe disease such as terminal ileitis and mesenteric lymphadenitis which also mimics appendicitis (203)(204)(205). Onset is generally 24 to 48 h following ingestion, with illness lasting between 7 and 14 days, but symptoms may persist for up to 2 to 12 months (201,205). Bloody stools occur in 20 to 46% of cases, and host susceptibility, number of ingested organisms, and serotype are determining factors for severity of disease (201).…”

Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

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Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Bacterial Gastroenteritis

2015

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SUMMARY Bacterial gastroenteritis is a disease that is pervasive in both the developing and developed worlds. While for the most part bacterial gastroenteritis is self-limiting, identification of an etiological agent by bacterial stool culture is required for the management of patients with severe or prolonged diarrhea, symptoms consistent with invasive disease, or a history that may predict a complicated course of disease. Importantly, characterization of bacterial enteropathogens from stool cultures in clinical laboratories is one of the primary means by which public health officials identify and track outbreaks of bacterial gastroenteritis. This article provides guidance for clinical microbiology laboratories that perform stool cultures. The general characteristics, epidemiology, and clinical manifestations of key bacterial enteropathogens are summarized. Information regarding optimal specimen collection, transport, and processing and current diagnostic tests and testing algorithms is provided. This article is an update of Cumitech 12A (P. H. Gilligan, J. M. Janda, M. A. Karmali, and J. M. Miller, Cumitech 12A, Laboratory diagnosis of bacterial diarrhea, 1992).

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Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

Section: Yersinia Enterocolitica and Yersinia Pseudotuberculosismentioning

confidence: 99%

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Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Bacterial Gastroenteritis

2015

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“…In contrast, Y. pseudotuberculosis often disseminates deeply to the mesenteric lymph nodes. Clinical presentation is characterized by enterocolitis (diarrhea, abdominal pain, fever, and sometimes vomiting) (2), which predominates in young children and is often self-limiting. However, diarrhea is a predominant symptom of Y. enterocolitica infection whereas abdominal pain is more usual in Y. pseudotuberculosis infection.…”

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confidence: 99%

Fast and Sensitive Detection of Enteropathogenic Yersinia by Immunoassays

et al. 2015

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Yersinia enterocolitica and Yersinia pseudotuberculosis, the two Yersinia species that are enteropathogenic for humans, are distributed worldwide and frequently cause diarrhea in inhabitants of temperate and cold countries. Y. enterocolitica is a major cause of foodborne disease resulting from consumption of contaminated pork meat and is further associated with substantial economic cost. However, investigation of enteropathogenic Yersinia species is infrequently performed routinely in clinical laboratories because of their specific growth characteristics, which make difficult their isolation from stool samples. Moreover, current isolation procedures are time-consuming and expensive, thus leading to underestimates of the incidence of enteric yersiniosis, inappropriate prescriptions of antibiotic treatments, and unnecessary appendectomies. The main objective of the study was to develop fast, sensitive, specific, and easy-to-use immunoassays, useful for both human and veterinary diagnosis. T he genus Yersinia belongs to the family of Enterobacteriaceae and is composed of three human-pathogenic species: Yersinia pestis, the causative agent of the plague, and Yersinia enterocolitica and Y. pseudotuberculosis, responsible for human enteric yersiniosis. Enteric yersiniosis is a foodborne disease caused by consumption of contaminated food or water (1) and can be transmitted between humans through the fecal-oral route. The disease is usually characterized by a self-limiting acute infection beginning in the intestine and is often limited to the ileocecal junction for Y. enterocolitica. In contrast, Y. pseudotuberculosis often disseminates deeply to the mesenteric lymph nodes. Clinical presentation is characterized by enterocolitis (diarrhea, abdominal pain, fever, and sometimes vomiting) (2), which predominates in young children and is often self-limiting. However, diarrhea is a predominant symptom of Y. enterocolitica infection whereas abdominal pain is more usual in Y. pseudotuberculosis infection. Moreover, Y. pseudotuberculosis can also cause different clinical symptoms such as scarlatinoid rash, conjunctivitis, acute organ failure, and toxic shock syndrome often reported in Far East (3). For both enteropathogenic Yersinia species, more-serious infections and sepsis can also occur, particularly in new-born, elderly, and immunocompromised patients. Sometimes, the infection appears as a pseudoappendicular syndrome in which mesenteric lymph nodes are involved, thus possibly leading to unnecessary appendectomies (4). Some secondary complications such as reactive arthritis and erythema nodosum are sometimes observed (5, 6). Rarely, Y. enterocolitica is responsible for a serious sepsis incident after transfusion of contaminated red blood cell preparations (7).Y. enterocolitica and Y. pseudotuberculosis are widespread worldwide, with a higher incidence in cold and temperate regions. pseudotuberculosis serotypes I and III are the prevailing isolated strains (9). The incidence of human enteric yersiniosis has been estimated to...

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