Clinical applications of growth factors in bone injuries: Experience with BMPs

Ronga, Mario; Fagetti, Alessandro; Canton, Gianluca; Paiusco, Elia; Surace, Michele Francesco; Cherubino, Paolo

doi:10.1016/s0020-1383(13)70008-1

Cited by 89 publications

(48 citation statements)

References 39 publications

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“…BMPs have revealed a promising future in the field of Bioengineering and Regenerative Medicine (Einhorn & Gerstenfeld, 2015). Numerous studies support the use of BMPs in nonunions in oral surgery, sinus lift bone grafting, and periodontal regeneration ( Table 2; Carreira, Lojudice, et al, 2014;Ronga et al, 2013). Table 3 shows BMPs approved in the United States and European Union.…”

Section: Approaches For Delivering Recombinant Bmpmentioning

confidence: 99%

Bone Morphogenetic Proteins

Carreira

Zambuzzi

Rossi

et al. 2015

Vitamins &Amp; Hormones

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Section: Approaches For Delivering Recombinant Bmpmentioning

confidence: 99%

Bone Morphogenetic Proteins

Carreira

Zambuzzi

Rossi

et al. 2015

Vitamins &Amp; Hormones

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“…Generally, these recombining proteins are being utilized as supporting parts in the bone loss treatments [111,112]. It is known that the BMP-2 and BMP-7 are being evaluated in clinical trials, but only a limited number of patients have been treated so far with long-term follow ups [113][114][115].…”

Section: Gene Therapy: Another Manner For Accelerating Bone Repairmentioning

confidence: 99%

Cellular behavior as a dynamic field for exploring bone bioengineering: A closer look at cell–biomaterial interface

Gemini-Piperni

Takamori²,

Sartoretto

et al. 2014

Archives of Biochemistry and Biophysics

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“…BMPs are extensively studied and widely recognized as key factors in a variety of chondrogenic and skeletogenic functions during normal embryonic development [5]. BMPs belong to the transforming growth factor β (TGF-β) super family and are considered to be a diverse group of phylogenetically conserved GFs, 20 members of which have been identified so far [6].…”

Section: Introductionmentioning

confidence: 99%

Clinical application of bone morphogenetic proteins for bone healing: a systematic review

Krishnakumar

Roffi

Reale

et al. 2017

International Orthopaedics (SICOT)

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Purpose This paper documents the existing evidence on bone morphogenetic proteins (BMPs) use for the treatment of bone fractures, non-union, and osteonecrosis, through a review of the clinical literature, underlying potential and limitations in terms of cost effectiveness and risk of complications. Methods A systematic review was performed on the PubMed database using the following string: (bone morphogenetic proteins OR BMPs) and (bone repair OR bone regeneration) including papers from 2000 to 2016. The search focused on clinical trials dealing with BMPs application to favor bone regeneration in bone fractures, non-union, and osteonecrosis, in English language, with level of evidence I, II, III, and IV. Relevant data (type of study, number of patients, BMPs delivery material, dose, site, follow-up, outcome, and adverse events) were extracted and analyzed. Results Forty-four articles met the inclusion criteria: 10 randomized controlled trials (RCTs), 7 comparative studies, 18 case series, and 9 case reports. rhBMP-2 was documented mainly for the treatment of fractures, and rhBMP-7 mainly for non-unions and osteonecrosis. Mixed results were found among RCTs and comparative papers: 11 reported positive results for BMPs augmentation, 3 obtained no significant effects, and 2 showed negative results. The only study comparing the two BMPs showed a better outcome with rhBMP-2 for non-union treatment. Conclusion Clinical evidence on BMPs use for the treatment of fractures, non-union, and osteonecrosis is still controversial, with the few available reports being mainly of low quality. While positive findings have been described in many studies, mixed results are still present in the literature in terms of efficacy and adverse events. The difficulties in drawing clear conclusions are also due to the studies heterogeneity, mainly in terms of different BMPs applied, with different concomitant treatments for each bone pathology. Therefore, further research with well-designed studies is needed in order to understand the real potential of this biological approach to favour bone healing.

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Clinical applications of growth factors in bone injuries: Experience with BMPs

Cited by 89 publications

References 39 publications

Bone Morphogenetic Proteins

Bone Morphogenetic Proteins

Cellular behavior as a dynamic field for exploring bone bioengineering: A closer look at cell–biomaterial interface

Clinical application of bone morphogenetic proteins for bone healing: a systematic review

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