Clinical applications of Gallium-68

Banerjee, Sangeeta Ray; Pomper, Martin G.

doi:10.1016/j.apradiso.2013.01.039

Cited by 200 publications

(169 citation statements)

References 97 publications

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“…Among in vivo, functional imaging techniques, Positron Emission Tomography is one of the most sophisticated methods that also makes it possible to detect tumors with high accuracy and sensitivity followed by easy quantification (Wester 2007 Ga-generators and offers a well-established complexation chemistry for the labeling of biomolecules (Velikyan 2013;Smith et al, 2013;Banerjee and Pomper 2013). To our knowledge, only a few 68 Ga-labeled NGR conjugates were evaluated under preclinical circumstances for CD13-expression-imaging (Zhang et al, 2014;Shao et al, 2014b).…”

Section: Introductionmentioning

confidence: 99%

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

Máté

Kertész

Enyedi

et al. 2015

European Journal of Pharmaceutical Sciences

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Purpose: Aminopeptidase N (APN/CD13) plays an important role in tumor neoangiogenic process and the development of metastases. Furthermore, it may serve as a potential target for cancer diagnosis and therapy. Previous studies have already shown that asparagine-glycinearginine (NGR) peptides specifically bind to APN/CD13. The aim of the study was to synthesize and investigate the APN/CD13 specificity of a novel 68

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Section: Introductionmentioning

confidence: 99%

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

Máté

Kertész

Enyedi

et al. 2015

European Journal of Pharmaceutical Sciences

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“…In current clinical practice, 68 Ga and 111 In are common radiolabels used in the preoperative evaluation of lesions using PET-or SPECT-based imaging, respectively (6).…”

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confidence: 99%

Evaluation of a Fluorescent and Radiolabeled Hybrid Somatostatin Analog In Vitro and in Mice Bearing H69 Neuroendocrine Xenografts

et al. 2016

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In the treatment of neuroendocrine tumors (NETs), complete surgical removal of malignancy is generally desirable, because it offers curative results. Preoperative guidance with radiolabeled somatostatin analogs, commonly used for NET diagnosis and preoperative planning, is limited by its low resolution, with the risk that tumor margins and small metastases will be incompletely resected with subsequent recurrence. A single hybrid probe combining radiotracer and optical dye would enable high-resolution optical guidance, also during surgery. In the current study, the hybrid labeled somatostatin analog Cy5-DTPA-Tyr 3 -octreotate (DTPA is diethylene triamine pentaacetic acid) was synthesized and evaluated for its ability to specifically trace NET cells in vitro and in an animal model. The performance of the hybrid tracer was compared with that of octreotate with only radiolabel or only optical label. Methods: The binding affinity and internalization capacity of Cy5-DTPA-Tyr 3 -octreotate were assessed in vitro. Biodistribution profiles and both nuclear and optical in vivo imaging of Cy5-111 In -DTPA-Tyr 3 -octreotate were performed in NET-bearing mice and compared with the performance of 111 In-DTPA-Tyr 3 -octreotate. Results: In vitro studies showed a low receptor affinity and internalization rate for Cy5-DTPA-Tyr 3 -octreotate. The dissociation constant value was 387.7 ± 97.9 nM for Cy5-DTPA-Tyr 3 -octreotate, whereas it was 120.5 ± 18.1 nM for DTPA-Tyr 3 -octreotate. Similarly, receptor-mediated internalization reduced from 33.76% ± 1.22% applied dose for DTPA-Tyr 3 -octreotate to 1.32% ± 0.02% applied dose for Cy5-DTPA-Tyr 3 -octreotate. In contrast, in vivo and ex vivo studies revealed similar tumor uptake values of Cy5-111 In-DTPA-Tyr 3 -octreotate and 111 In -DTPA-Tyr 3 -octreotate (6.93 ± 2.08 and 5.16 ± 1.27, respectively). All organs except the kidneys showed low background radioactivity, with especially low activities in the liver, and high tumor-to-tissue ratios were achieved-both favorable for the tracer's toxicity profile. Hybrid imaging in mice confirmed that the nuclear and fluorescence signals colocalized. Conclusion: The correlation between findings with the optical and the nuclear probes underlines the potential of combining SPECT imaging with fluorescence guidance and shows the promise of this novel hybrid peptide for preoperative and intraoperative imaging of NET.

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“…7 In this case, it helped us confirming neuroendocrine origin of the pancreatic mass that was later discovered, not visualized in initial exams, and its relation to pulmonary nodules due to the same imaging profile with this technique. Biopsy, in addition to this information, confirmed the diagnosis.…”

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confidence: 67%

Neuroendocrine Tumor, diagnostic difficulties

Oliveira¹,

Ferreira²,

Rocha³

2017

Gal. Clin.

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Ectopic adrenocorticotropic hormone (ACTH) secretion is a rare disease. A 51 years old woman, with a Cushing syndrome secondary to ectopic ACTH secretion, diagnosed in 2009, with mediastinal lymphadenopathy, whose biopsy was compatible with lung small cell carcinoma, staged as IIIB using TNM classification. No other lesions were found in patient study. The patient was submitted to chemotherapy, associated to ketoconazole 200 mg twice daily, with partial remission of both conditions. Three years later was admitted with an aggravation of Cushing syndrome. There was no evidence of progression of pulmonary disease. A cystic lesion in the pancreatic uncinated process was found by abdominal CT scan and with avid uptake by DOTANOC PET discreet in anterior mediastinal lymphadenopathy. Biopsy of pancreatic mass revealed a neuroendocrine tumor. Pulmonary masses were biopsied again and was in favor of neuroendocrine tumor. It was assumed the diagnosis of pancreatic neuroendocrine tumor with mediastinal metastasis. The patient initiated lanreotid (120 mg, monthly, subcutaneous) in association with ketoconazole. After 5 months of therapy, patient died with sepsis secondary to pneumonia. Neuroendocrine tumours are rare, difficult to diagnose and with poor prognosis when associated with ectopic ACTH secreting Cushing syndrome.

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Clinical applications of Gallium-68

Cited by 200 publications

References 97 publications

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

Evaluation of a Fluorescent and Radiolabeled Hybrid Somatostatin Analog In Vitro and in Mice Bearing H69 Neuroendocrine Xenografts

Neuroendocrine Tumor, diagnostic difficulties

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