Clinical Application of the Forced Oscillation Technique

Shirai, Toshihiro; Kurosawa, Hájíme

doi:10.2169/internalmedicine.55.5876

Cited by 89 publications

(100 citation statements)

References 46 publications

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“…However, correlation coefficients in these previous reports showed only fair–moderate agreement. Shirai and Kurosawa reported that FOT is not a surrogate test for spirometry, because the tests are not identical 16. Consistently with previous reports, the present study demonstrated that most FOT indices are significantly correlated with spirometric indices, but the correlation is only fair–moderate.…”

Section: Discussionsupporting

confidence: 89%

“…Respiratory impedance was measured using a commercially available multifrequency FOT device (MostGraph-01; Chest MI, Tokyo, Japan) as previously reported12–14 and following standard recommendations 16,17. Briefly, oscillatory signals generated by a loudspeaker at 0.25-second intervals were applied to the respiratory system through a mouthpiece during tidal breathing at rest.…”

Section: Methodsmentioning

confidence: 99%

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Use of the forced-oscillation technique to estimate spirometry values

Yamamoto¹,

Miyoshi²,

Katayama³

et al. 2017

COPD

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PurposeSpirometry is sometimes difficult to perform in elderly patients and in those with severe respiratory distress. The forced-oscillation technique (FOT) is a simple and noninvasive method of measuring respiratory impedance. The aim of this study was to determine if FOT data reflect spirometric indices.Patients and methodsPatients underwent both FOT and spirometry procedures prior to inclusion in development (n=1,089) and validation (n=552) studies. Multivariate linear regression analysis was performed to identify FOT parameters predictive of vital capacity (VC), forced VC (FVC), and forced expiratory volume in 1 second (FEV1). A regression equation was used to calculate estimated VC, FVC, and FEV1. We then determined whether the estimated data reflected spirometric indices. Agreement between actual and estimated spirometry data was assessed by Bland–Altman analysis.ResultsSignificant correlations were observed between actual and estimated VC, FVC, and FEV1 values (all r>0.8 and P<0.001). These results were deemed robust by a separate validation study (all r>0.8 and P<0.001). Bias between the actual data and estimated data for VC, FVC, and FEV1 in the development study was 0.007 L (95% limits of agreement [LOA] 0.907 and −0.893 L), −0.064 L (95% LOA 0.843 and −0.971 L), and −0.039 L (95% LOA 0.735 and −0.814 L), respectively. On the other hand, bias between the actual data and estimated data for VC, FVC, and FEV1 in the validation study was −0.201 L (95% LOA 0.62 and −1.022 L), −0.262 L (95% LOA 0.582 and −1.106 L), and −0.174 L (95% LOA 0.576 and −0.923 L), respectively, suggesting that the estimated data in the validation study did not have high accuracy.ConclusionFurther studies are needed to generate more accurate regression equations for spirometric indices based on FOT measurements.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Use of the forced-oscillation technique to estimate spirometry values

Yamamoto¹,

Miyoshi²,

Katayama³

et al. 2017

COPD

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“…R5‐R20, often termed frequency dependence of resistance, correlated significantly to R tot , S acin and LCI at most time‐points before and after the inhaled allergen challenge and to S cond 23 hours post‐challenge. R5‐R20 has in some publications been interpreted as an index of peripheral airway resistance, while others have stated that it should be viewed as a heterogeneity of ventilation . Based on our findings, we hypothesize that both peripheral airway resistance and ventilation heterogeneity are associated with an increased R5‐R20.…”

Section: Discussionsupporting

confidence: 66%

Small airway involvement in the late allergic response in asthma

Stenberg

Diamant

Ankerst

et al. 2017

Clin Experimental Allergy

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“…Wheezing during resting expiration is considered to be a more severe symptom than that during forced expiration [16]; thus, if the patient is found to have wheezing in a clinical interview, which is assumed that asthma is inadequately controlled, the treatment strategy would be re-evaluated. The respiratory reactance indicators Fres and AX are considered to primarily reflect the elastic properties of the respiratory system [17], and are associated with small-airway dysfunction in asthma [18]; however, the clinical significance Open Journal of Respiratory Diseases of Fres and AX remains unclear. Both Fres and AX were high, not only in the groups with inadequately controlled asthma, but also in the high-score groups for limitation of normal daily activities and shortness of breath, which are exercise-induced symptoms.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Asthma Symptoms to Assess Asthma Control Status in a Primary Care Setting: An Exploratory Analysis of Pooled Data from Three Trials

Hozawa¹,

Terada²,

Hozawa³

2018

OJRD

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Background: Primary care physicians in Japan see many patients in a given day; consequently, they find it challenging to devote sufficient time for detailed clinical consultation and evaluation of asthma control status. The aim of this study was to investigate asthma symptoms that reveal the presence of inadequately controlled asthma. Methods: A pooled analysis of baseline data from 100 patients with asthma treated with inhaled corticosteroid(s) (ICS) alone or ICS/long-acting beta-agonist who participated in three previous clinical trials was performed. Asthma control status and asthmatic symptoms were determined using a five-item Asthma Control Questionnaire, and whether asthmatic symptoms reflect clinical markers was investigated. Results: Nocturnal awakening owing to asthmatic symptoms was observed only in the uncontrolled asthma group. Patient-reported wheezing was not observed in the group with well-controlled asthma, but was observed in all patients in the uncontrolled asthma group. Virtually all patients, irrespective of asthma control status, reported symptoms in the morning, limitation of normal daily activities, and shortness of breath. Conclusions: The presence of nocturnal awakening due to asthma and wheezing likely reflected uncontrolled asthma. These results will lead to re-recognition that clinical interview, querying nocturnal awakening from asthma and wheezing is a simple and useful approach to assess asthma control status in a primary care setting.

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Clinical Application of the Forced Oscillation Technique

Cited by 89 publications

References 46 publications

Use of the forced-oscillation technique to estimate spirometry values

Use of the forced-oscillation technique to estimate spirometry values

Small airway involvement in the late allergic response in asthma

Evaluation of Asthma Symptoms to Assess Asthma Control Status in a Primary Care Setting: An Exploratory Analysis of Pooled Data from Three Trials

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