Clinical application of ¹⁸F-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography for cancer cells in lung cancer

Synthesis and In Vitro Biological Evaluation of New Pyrido[2,3‐b]pyrazinone‐Based Cytotoxic Agents and Molecular Docking as BRAF Inhibitors

“…Cyclization of acid hydrazide Schiff bases 4 a-c with acetic anhydride provided oxadiazole in addition to acylation of NH of oxadiazole compounds 5 a-c. 1 H NMR spectrum showed additional singlet signal at 2.33-2.34 ppm assigned to COCH 3 protons with disappearance of azomethane proton, as well as the exchangeable NH protons.…”

“…Triazol-5-ones / Triazol-5-thione 8 a-c were obtained by refluxing equimolar amounts of the acid hydrazide 3 and appropriate isocyanate or isothiocyanate in absolute ethanol for 24 h. IR spectrum showed a band at 1270 cm À 1 attributed to C=S for compound 8 c. 1 H NMR spectrum showed additional multiplet signals at 6.60-8.10 ppm corresponding to aromatic protons. In addition to a singlet signal at 4.00-4.31 ppm exchanged with D 2 O corresponding to NH protons.…”

“…Cancer occur by a series of successive mutation in genes, resulting in cell function change, proliferation and differentiation. [1][2][3] Both cell proliferation and differentiation are regulated by MAPK signaling pathway (Ras-Raf-MEK-ERK cascade). RAF protein kinase family (ARAF, BRAF and CRAF) is a potential key element in the activation of MAPK signaling pathway.…”