Clinical application of oblique transverse access to bifurcation of the common carotid artery

Mikhailov, I. P.; Lemenev, V L; Kungurtsev, E. V.; Arustamyan, V. A.

doi:10.17116/operhirurg2018223

Cited by 2 publications

(1 citation statement)

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“…[ 34–36 ] Moreover, improved wound contraction and wound debridement were found to be increased with the topical application of a zinc oxide cream in rats full‐thickness wound. [ 37,38 ] Besides, in the later stages of wound healing (e.g., proliferation and remodeling), copper ion (Cu 2+ ) is proved to induce expression of vascular endothelial growth factor, promote angiogenesis and maintain the stability of collagen. [ 16,39 ] Although the application of metal ions presents improvement for wound healing, the uncontrolled administration of single or multiple ions should be avoided.…”

Section: Introductionmentioning

confidence: 99%

Freeze‐Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing

Xiao

Zhou

et al. 2020

Adv Healthcare Materials

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Imbalance of metal ions in the wound microenvironment is a key factor that leads to delayed wound healing. However, single metal administration to enhance wound repair is usually not enough due to the overlapping nature of the wound healing phases. Herein, a facile freeze‐thawing strategy is developed to incorporate chitosan/ions hydrogel into medical gauzes to realize on‐demand release of multiple ions to accelerate wound healing. In vitro study reveals that the gauzes can temporally release multiple metal ions on demand, and the released metal ions show effectiveness in killing bacteria and expediting cell migration. In vivo studies demonstrate that the metal ions loaded gauzes can efficiently enhance infected wound healing. Further histological analysis find that these metal ion‐loaded gauzes accelerate wound healing by promoting granulation formation, collagen deposition and maturation, re‐epithelization, angiogenesis, and inhibiting inflammation via regulating the expression of inflammatory factors (e.g., tumor necrosis factor‐α) and polarization of macrophages. Thus, this novel metal ions delivery system has great potential in infected tissue repair and antibacterial applications.

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Section: Introductionmentioning

confidence: 99%