Clinical application of Hg-free piezo-ICSI using fluorinert

Morita, H.; Kamihata, M.; Hirosawa, Takayasu; Kuwahata, A.; Ochi, Manami; Horiuchi, Toshitaka

doi:10.1016/j.fertnstert.2012.07.587

Cited by 2 publications

(3 citation statements)

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“…However, assuming the clinical application of P‐ICSI to humans, mercury is a potential neurotoxin and difficult to handle, store, and manage safely on a clinical field. Modern piezo injectors usually use fluorinert (stable fluorocarbon‐based fluid) instead of mercury . These commercialized safe devices and dedicated pipettes for P‐ICSI are now available in Japan.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the effect of piezo‐intracytoplasmic sperm injection on the laboratory, clinical, and neonatal outcomes

Fujii

Endo

Mitsuhata

et al. 2020

Reprod Medicine & Biology

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Purpose Limited research has been published on the effect of piezo‐assisted intracytoplasmic sperm injection (P‐ICSI). We evaluated the effect of P‐ICSI on the laboratory, clinical, and neonatal outcomes. Methods This retrospective study was based on the data collected between April 2011 and October 2016. Total 1348 mature oocytes from 145 patients were analyzed. Laboratory, clinical, and neonatal outcomes of those given conventional intracytoplasmic sperm injection (C‐ICSI) and those administered P‐ICSI were examined. Results P‐ICSI showed significantly more favorable results, with a survival rate of 97.0% (C‐ICSI: 94.1%, P < .010) and a fertilization rate of 83.5% (C‐ICSI: 70.6%, P < .001). There were no differences in the blastocyst development rate, implantation rate, miscarriage rate, live birth rate, gestational age, birth weight, proportion of male neonates, cesarean section rate, and congenital abnormalities between the two patient groups. Conclusions Our comparison of P‐ICSI with C‐ICSI showed that P‐ICSI significantly improved the survival and fertilization.

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Section: Discussionmentioning

confidence: 99%

“…Modern piezo injectors usually use fluorinert (stable fluorocarbon-based fluid) instead of mercury. 8,28,30 These commercialized safe devices and dedicated pipettes for P-ICSI are now available in Japan. A large number of P-ICSI has already been performed.…”

Section: Information On Neonatal Outcomes Was Obtained In 22 Newbornsmentioning

confidence: 99%

Evaluation of the effect of piezo‐intracytoplasmic sperm injection on the laboratory, clinical, and neonatal outcomes

Fujii

Endo

Mitsuhata

et al. 2020

Reprod Medicine & Biology

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“…Modern piezoelectric injectors use fluorinert (a stable fluorocarbon-based fluid) to avoid the use of mercury (100). Hiraoka and Kitamura (101) showed that piezoelectric ICSI performed with a flat, spiked, extra-thin glass micropipette 0.625 mm in diameter (improved piezoelectric ICSI ) had excellent biologic and clinical outcomes.…”

Section: Oocytesmentioning

confidence: 99%

Are we approaching automated assisted reproductive technology? Sperm analysis, oocyte manipulation, and insemination

Casciani¹,

Galliano

Franasiak

et al. 2021

F&S Reviews

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Assisted reproductive technology (ART) procedures are mostly performed manually and require meticulous attention to details and precision in handling and timing. Automation of ART procedures would allow achieving standardization and reducing performance variability, the cost of medical treatment, and the risk of human error. Some ART diagnostic devices are already available and offer objective tools of evaluation. However, automation of the entire spectrum of ART procedures is yet to come and can only be imagined as a platform capable of integrating all the separate technologies, successfully interconnecting them to guarantee a continued chain of custody of the gametes and embryos. The present update seeks to review the current potential for automation within the in vitro fertilization laboratory, with attention to sperm and oocyte manipulation and selection and to oocyte insemination with standard in vitro fertilization or intracytoplasmic sperm injection. An electronic search of PubMed was performed to identify articles in English that addressed automation in ART. Studies were classified in categories as randomized controlled trials, prospective controlled trials, prospective noncontrolled trials, retrospective studies, and experimental studies. Research and development data from the authors are included.

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Clinical application of Hg-free piezo-ICSI using fluorinert

Cited by 2 publications

References 0 publications

Evaluation of the effect of piezo‐intracytoplasmic sperm injection on the laboratory, clinical, and neonatal outcomes

Evaluation of the effect of piezo‐intracytoplasmic sperm injection on the laboratory, clinical, and neonatal outcomes

Are we approaching automated assisted reproductive technology? Sperm analysis, oocyte manipulation, and insemination

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