Clinical Application of Dual-Energy Spectral Computed Tomography in Detecting Cholesterol Gallstones From Surrounding Bile

Chen, Yang; Zhang, Shuang; Jia, Yongjun; Duan, Haifeng; Ma, Genshan; Zhang, Xirong; Yan, Yu; He, Tao

doi:10.1016/j.acra.2016.10.006

Cited by 46 publications

(31 citation statements)

References 15 publications

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“…Because the use of dual-energy CT with virtual monochromatic imaging can facilitate increased conspicuity of noncalcified gallstones, it is logical to deduce that virtual monochromatic imaging can also be used to increase the visualization of stones in the biliary ducts. This benefit also is possible because cholesterol-filled gallstones have an energy-dependent x-ray attenuation curve that is distinctively different from that of bile (23,24). In our experience, a bile duct stone that is isoattenuating to bile at conventional CT or 70-keV dualenergy CT appears with lower attenuation than bile at low-energy 40-keV imaging and with higher attenuation than bile at high-energy 190-keV imaging, similar to stones in the gallbladder.…”

Section: Choledocholithiasismentioning

confidence: 69%

“…Gallstones that are isoattenuating to bile at conventional CT or 70-keV dual-energy CT become more conspicuous on higher-and lowerkiloelectron-volt virtual monochromatic images because cholesterol-containing gallstones have an energy-dependent x-ray attenuation curve that is distinctively different from that of bile (24). Noncalcified cholesterol-containing gallstones appear to have lower attenuation than bile on low-energy 40-keV images, but they appear hyperattenuating on high-energy 190-keV images ( Fig 5).…”

Section: Gallbladder Disease and Associated Complications Cholelithiasismentioning

confidence: 99%

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Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease

et al. 2018

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Imaging of the gallbladder has a key role in the examination of patients with abdominal pain-especially pain localized to the right upper quadrant. Pathologic conditions that affect the gallbladder include cholelithiasis and associated complications such as acute and chronic cholecystitis, choledocholithiasis, gallstone pancreatitis, and cancer. Modalities used to image the gallbladder include ultrasonography (US), computed tomography (CT), magnetic resonance (MR) imaging, and nuclear scintigraphy. US is the primary imaging modality used to evaluate entities suspected of being gallbladder disease, as it is both sensitive and specific for demonstrating gallstones, biliary duct dilatation, and inflammatory features. However, CT is often the first imaging examination performed in patients who present to the emergency department with acute abdominal pain. Because the CT appearance of gallstones is variable, depending on the composition of the stone, pattern of calcification, and presence of gas, gallstones and other gallbladder conditions can be difficult to detect at conventional multidetector CT, with which data are acquired by using a single x-ray energy spectrum. Dual-energy CT, with which one takes advantage of the material-dependent x-ray absorption behavior of concurrently acquired high- and low-kilovolt-peak data, can add value by increasing the conspicuity of noncalcified gallstones and improving the detection of acute cholecystitis and gallbladder malignancy. In addition, MR cholangiopancreatography can be helpful for assessing choledocholithiasis and complicated biliary duct disease. RSNA, 2018.

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Section: Choledocholithiasismentioning

confidence: 69%

Section: Gallbladder Disease and Associated Complications Cholelithiasismentioning

confidence: 99%

Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease

et al. 2018

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“…Our results showed that each of the selected drugs had different X-ray absorption, thus facilitating their assessment in the gastrointestinal tract. These differences result in differences in image densities, which, in addition to their size and shape, should allow the differentiation of medicines from other potential foreign bodies in the gastrointestinal tract, e.g., stones [12][13][14] and bezoars [15][16][17][18]. The pills could easily be measured on abdominal CT images and could be compared with the attenuation and noise of typical medications, as listed in table 1, to narrow down the possible identity of the agent.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography imaging for the characterisation of drugs with radiation density measurements and HU spectroscopy

Sieroń¹,

Steib²,

Suter³

et al. 2018

Swiss Med Wkly

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“…Sämtliche Studien zu anderen Organsystemen, die sich darüber hinaus aus der Literaturrecherche ergaben, behandelten die Fettdetektion und nicht die Fettquantifizierung und wurden entsprechend ebenfalls ausgeschlossen. Beispielhaft wurde die DECT-Fettdetektion in diesen Studien zur Differenzierung von chirurgisch bestätigten Cholesterol-Gallensteinen gegenüber Gallenflüssigkeit [18], zur Differenzierung von Ex-vivo-Herzmuskel oder Blutthromben gegenüber Fett [19], zur Festlegung idealer keV-Werte zur Detektion fetthaltiger und kalkhalti- ger Koronarplaques [20] sowie zur Detektion von im Kaninchen gesetzten pulmonalen Fettembolien [21] genutzt.…”

Section: Methodikunclassified

Dual-Energy Computed Tomography for Fat Quantification in the Liver and Bone Marrow: A Literature Review

Molwitz

Leiderer

Özden

et al. 2020

Rofo

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Background With dual-energy computed tomography (DECT) it is possible to quantify certain elements and tissues by their specific attenuation, which is dependent on the X-ray spectrum. This systematic review provides an overview of the suitability of DECT for fat quantification in clinical diagnostics compared to established methods, such as histology, magnetic resonance imaging (MRI) and single-energy computed tomography (SECT). Method Following a systematic literature search, studies which validated DECT fat quantification by other modalities were included. The methodological heterogeneity of all included studies was processed. The study results are presented and discussed according to the target organ and specifically for each modality of comparison. Results Heterogeneity of the study methodology was high. The DECT data was generated by sequential CT scans, fast-kVp-switching DECT, or dual-source DECT. All included studies focused on the suitability of DECT for the diagnosis of hepatic steatosis and for the determination of the bone marrow fat percentage and the influence of bone marrow fat on the measurement of bone mineral density. Fat quantification in the liver and bone marrow by DECT showed valid results compared to histology, MRI chemical shift relaxometry, magnetic resonance spectroscopy, and SECT. For determination of hepatic steatosis in contrast-enhanced CT images, DECT was clearly superior to SECT. The measurement of bone marrow fat percentage via DECT enabled the bone mineral density quantification more reliably. Conclusion DECT is an overall valid method for fat quantification in the liver and bone marrow. In contrast to SECT, it is especially advantageous to diagnose hepatic steatosis in contrast-enhanced CT examinations. In the bone marrow DECT fat quantification allows more valid quantification of bone mineral density than conventional methods. Complementary studies concerning DECT fat quantification by split-filter DECT or dual-layer spectral CT and further studies on other organ systems should be conducted. Key points: Citation Format

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Clinical Application of Dual-Energy Spectral Computed Tomography in Detecting Cholesterol Gallstones From Surrounding Bile

Cited by 46 publications

References 15 publications

Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease

Multimodality Imaging, including Dual-Energy CT, in the Evaluation of Gallbladder Disease

Computed tomography imaging for the characterisation of drugs with radiation density measurements and HU spectroscopy

Dual-Energy Computed Tomography for Fat Quantification in the Liver and Bone Marrow: A Literature Review

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