Clinical application of d-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis deformans

Minami, Saburo; Hata, Motoji; Tamai, Yoshin; Hashida, Masaki; Takayama, T.; Yamamoto, Satoshi; Okada, Michiyo; Funatsu, Toshihiro; Tsuka, Takeshi; Imagawa, Tomohiro; Okamoto, Yoshiharu

doi:10.1016/j.carbpol.2010.06.021

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…We did not directly confirm type II collagen and proteoglycan synthesis in dogs after administration of GlcN. However, oral administration of GlcN induced obvious functional recovery in various kinds of canine orthopedic diseases [ 2 ]. To confirm these phenomena occur in dogs is required to understand the mechanism of GlcN in dog joint diseases.…”

Section: Resultsmentioning

confidence: 99%

“…Glucosamine hydrochloride (GlcN) and N -acetyl- d -glucosamine (GlcNAc) are components of glycosaminoglycan now widely used as dietary supplements [ 1 ]. Moreover, GlcN is useful for the treatment of joint diseases both in humans and in veterinary medicine, including dogs and horses [ 2 , 3 ]. The bioavailability of GlcN has been reported as 26% in humans [ 4 ], 19% in rats [ 5 ], 12% in dogs [ 6 ], and 2–6.1% in horses [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs

et al. 2011

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We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-d-glucosamine (GlcNAc) and d-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs. The PFAA concentrations increased in the control group and the GlcNAc group at one hour after feeding, and each amino acid concentration increased. On the other hand, in the GlcN group and the Glc group PFAA concentrations decreased at one hour after feeding. A significant decrease in amino acid concentration was observed for glutamate, glycine and alanine. Our results suggest the existence of differences in PFAA dynamics after oral administration of GlcN and GlcNAc in dogs.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs

et al. 2011

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“…The hydrostatic extraction is also performed with the aid of "water". In this regard, Kołodziejska et al reports one of the first research works on the effects of variable time (15 to 120 min) and temperature (45,70,100) in pure water for skin and back bones of fish and cod, respectively [119]. The authors found an astonishing 100% yield of gelatin at 45 • C after 15 to 60 min of the extraction procedure [119].…”

Section: Water Extractionmentioning

confidence: 99%

Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review

et al. 2021

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The collagen hydrolysate, a proteinic biopeptide, is used for various key functionalities in humans and animals. Numerous reviews explained either individually or a few of following aspects: types, processes, properties, and applications. In the recent developments, various biological, biochemical, and biomedical functionalities are achieved in five aspects: process, type, species, disease, receptors. The receptors are rarely addressed in the past which are an essential stimulus to activate various biomedical and biological activities in the metabolic system of humans and animals. Furthermore, a systematic segregation of the recent developments regarding the five main aspects is not yet reported. This review presents various biological, biochemical, and biomedical functionalities achieved for each of the beforementioned five aspects using a systematic approach. The review proposes a novel three-level hierarchy that aims to associate a specific functionality to a particular aspect and its subcategory. The hierarchy also highlights various key research novelties in a categorical manner that will contribute to future research.

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“…GlcN is useful for the treatment of joint diseases in both humans and animals [ 4 , 5 ]. The bioavailability of GlcN has been reported to be 26% in humans [ 6 ], 19% in rats [ 7 ], 12% in dogs [ 8 ], and 2%–6.1% in horses [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

et al. 2012

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D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).

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Clinical application of d-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis deformans

Cited by 8 publications

References 18 publications

Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs

Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs

Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review

Metabolomic Analyses of Blood Plasma after Oral Administration of D-Glucosamine Hydrochloride to Dogs

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