Clinical Application of Chitin Artificial Skin (Beschitin W)

Kifune, Koji

doi:10.1007/978-94-011-5942-5_2

Cited by 34 publications

(16 citation statements)

References 2 publications

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“…A chitin material, Beschitin ® , was used for human application as dressing for skin and nasal wounds (Kifune, 1992). From then on chitin and chitosan were consistently shown to enhance wound healing in animals (Okamoto et al, 1993) and human subjects (Azad et al, 2004).…”

Section: Chitosan Historymentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

471

215

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Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

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Section: Chitosan Historymentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

471

215

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“…The polymer skeleton, which consists of pyranose rings of β-(1→4)-2-acetamido-2-deoxy-β-D-glucose (chitin) and β-(1→4)-2-amino-2-deoxy-β-Dglucose (chitosan) linked with a glycosidic linkage, dictates many advantageous properties, for example; biodegradability, 1 biocompatibility, 2 bioactivity, 3 non-toxicity, 4 antimicrobial activities, 5 and ion absorption ability. 6 Based on those specific properties, chitin and chitosan have received much attention as biomaterials for value-added products, especially foods 7 and drugs 8 including cosmetics. 9 …”

Section: Introductionmentioning

confidence: 99%

Chitosan gallate as a novel potential polysaccharide antioxidant: an EPR study

Pasanphan

Buettner

Chirachanchai

2010

Carbohydrate Research

143

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A novel biopolymer-based antioxidant, chitosan conjugated with gallic acid (chitosan galloylate, chitosan– GA), is proposed. Electron paramagnetic resonance (EPR) demonstrates a wide range of antioxidant activity for chitosan–GA as evidenced from its reactions with oxidizing free radicals, that is, 1,1-diphenyl-2-picryl-hydrazyl (DPPH), horseradish peroxidase (HRP)–H2O2, carbon-centered alkyl radicals, and hydroxyl radicals. The EPR spectrum of the radical formed on chitosan–GA was attributed to the semiquinone radical of the gallate moiety. The stoichiometry and effective concentration (EC50) of the DPPH free radical with chitosan–GA show that the radical scavenging capacity is maintained even after thermal treatment at 100 °C for an hour. Although the degree of substitution of GA on chitosan was about 15%, its antioxidant capacity, that is, the reaction with carbon-centered and hydroxyl radicals, is comparable to that of GA.

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“…Chitin is a promising polymer for biomedical applications because of its biocompatibility, biodegradability and structural similarity to the glycosaminoglycans [2]. A number of clinical studies using chitin have been reported [3], including its use as a wound-dressing material [4][5][6], as a treatment of chronic gastroduodenitis [7], and as an endodontic treatment [8]. Recently, results have been reported from a clinical trial where chitin membranes were used to treat patients with deep burns, orthopedic injury, trauma and ulcer conditions [9].…”

Section: Introductionmentioning

confidence: 99%