Clinical Application of Breath Biomarkers of Oxidative Stress Status

Risby, Terence H.; Sehnert, Shelley S.

doi:10.1016/b978-0-444-50957-4.50010-7

Cited by 20 publications

(33 citation statements)

References 15 publications

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“…Thus, correction for background concentrations of volatile compounds in inspiratory air is necessary (Risby and Sehnert, 1999). To standardize the sampling procedure and to get rid of many inspiratory contaminants, correction for the actual background concentrations by subtracting them from the exhaled breath concentrations is often employed.…”

Section: Samplingmentioning

confidence: 99%

“…This feature is very important when analysing physiological samples. The identification of molecules in breath based only upon the mass-to-charge ratios of chemically ionized molecular ions is difficult (Mueller et al, 1998;Risby and Sehnert, 1999;Wilson and Monster, 1999;Ípan!l and Smith, 2001;Ípan!l et al, 2006).…”

Section: Analysis and Detectionmentioning

confidence: 99%

“…Carboxen (S BET = 1000 m 2 /g) is very hydrophobic and is suitable for highly volatile substances (hydrocarbons C2-C8, benzene, styrene). Graphitized activated carbon (S BET = 120 m 2 /g) is hydrophobic, adsorbs the smallest amount of water, and is suited for substances with a boiling point above 50°C (Mueller et al, 1998;Risby and Sehnert, 1999). The principal disadvantage of sorbent sampling is that it is not a realtime technique (Harper, 2000).…”

Section: Preconcentrationmentioning

confidence: 99%

“…During sample collection dead space air is pulled into the sampling system diluting the alveolar matrix thus affecting quantitation. Collection of breath samples can be done so that end expired air is sampled or mixed expired air is collected (Risby and Sehnert, 1999). The determination of partial pressure of CO 2 in breath is a useful factor to assess the representativeness of the taking samples.…”

Section: Samplingmentioning

confidence: 99%

“…The TOF instrument provides fast data proton transfer (Mueller et al, 1998;Risby and Sehnert, 1999;Ípan!l and Smith, 2001).…”

Section: Analysis and Detectionmentioning

confidence: 99%

See 4 more Smart Citations

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

672

531

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Over the last few years, breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, especially since breath sampling is a non-invasive technique, totally painless and agreeable to patients. The investigation of human breath samples with various analytical methods has shown a correlation between the concentration patterns of volatile organic compounds (VOCs) and the occurrence of certain diseases. It has been demonstrated that modern analytical instruments allow the determination of many compounds found in human breath both in normal and anomalous concentrations. The composition of exhaled breath in patients with, for example, lung cancer, inflammatory lung disease, hepatic or renal dysfunction and diabetes contains valuable information. Furthermore, the detection and quantification of oxidative stress, and its monitoring during surgery based on composition of exhaled breath, have made considerable progress. This paper gives an overview of the analytical techniques used for sample collection, preconcentration and analysis of human breath composition. The diagnostic potential of different disease-marking substances in human breath for a selection of diseases and the clinical applications of breath analysis are discussed.

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Section: Samplingmentioning

confidence: 99%

Section: Analysis and Detectionmentioning

confidence: 99%

Section: Preconcentrationmentioning

confidence: 99%

Section: Samplingmentioning

confidence: 99%

“…The TOF instrument provides fast data proton transfer (Mueller et al, 1998;Risby and Sehnert, 1999;Ípan!l and Smith, 2001).…”

Section: Analysis and Detectionmentioning

confidence: 99%

See 3 more Smart Citations

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

672

531

View full text Add to dashboard Cite

show abstract

Breath Analysis: Analytical Methodologies and Clinical Applications

Ceccarini

Francesco

Fuoco

et al. 2012

Analytical Techniques for Clinical Chemistry

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Breathomics from exhaled volatile organic compounds in pediatric asthma

Neerincx

Vijverberg

Bos

et al. 2017

Pediatric Pulmonology

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Asthma is the most common chronic disease in children, and is characterized by airway inflammation, bronchial hyperresponsiveness, and airflow obstruction. Asthma diagnosis, phenotyping, and monitoring are still challenging with currently available methods, such as spirometry, F NO or sputum analysis. The analysis of volatile organic compounds (VOCs) in exhaled breath could be an interesting non-invasive approach, but has not yet reached clinical practice. This review describes the current status of breath analysis in the diagnosis and monitoring of pediatric asthma. Furthermore, features of an ideal breath test, different breath analysis techniques, and important methodological issues are discussed. Although only a (small) number of studies have been performed in pediatric asthma, of which the majority is focusing on asthma diagnosis, these studies show moderate to good prediction accuracy (80-100%, with models including 6-28 VOCs), thereby qualifying breathomics for future application. However, standardization of procedures, longitudinal studies, as well as external validation are needed in order to further develop breathomics into clinical tools. Such a non-invasive tool may be the next step toward stratified and personalized medicine in pediatric respiratory disease.

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Clinical Application of Breath Biomarkers of Oxidative Stress Status

Cited by 20 publications

References 15 publications

Human exhaled air analytics: biomarkers of diseases

Human exhaled air analytics: biomarkers of diseases

Breath Analysis: Analytical Methodologies and Clinical Applications

Breathomics from exhaled volatile organic compounds in pediatric asthma

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