Clinical application of a new hyaluronic acid filler based on its rheological properties and the anatomical site of injection

Abstract

Background: Hyaluronic acid (HA) filler is the most commonly used filler for soft tissue augmentation. There are numerous commercially available HA fillers in the cosmetic market, and there are guidelines for each filler as determined by the manufacturing company. The successful use of injectable fillers requires an understanding of each option available so that the most appropriate form of hyaluronic acid may be selected for patients. The purpose of this study was to determine whether newly developed HA fillers are appropriate for forehead augmentation considering their rheological properties and the anatomical site of injection. Methods: The rheological properties of new HA fillers were assessed e.t.p.q. S100, S300, S500 (Zetema®). Comparing the rheological properties, the authors chose e.t.p.q. S300® for forehead augmentation. The filler was injected into the foreheads of 40 consecutive patients for esthetic purposes.Results: e.t.p.q. S300® was determined to be an appropriate filler for the forehead. The injection procedure employed was considered to be easy and safe when applied to the preperiosteal layer using a cannula. None of the patients had complications such as vascular compromise, infections, granulomas, or migration. Conclusions: Understanding the physical properties of new fillers is necessary. As the preperiosteal layer of the forehead is an appropriate layer for the filler injection, physicians should consider injecting fillers with enough strength to withstand the shearing forces.

Evaluation of the Rheologic and Physicochemical Properties of a Novel Hyaluronic Acid Filler Range with eXcellent Three-Dimensional Reticulation (XTR™) Technology

“…No individual product can be used for every indication; hence, the clinician's experience, as well as the specific guiding principles provided by the originating company, are often used as the bases for choosing the type of HA fillers that are appropriate for certain indications and for injection into specific anatomical layers. More importantly, whenever novel fillers and related technologies are introduced, developing a familiarity of the basic science of HA fillers would allow aesthetic medicine specialists to select the best options for their patients [7].…”

In vitro evaluation of viscosity of facial hyaluronic acid fillers through shear tension analysis. Preliminary data

“…Additionally, when considering volumizing in an aesthetic facial harmonization treatment, the practitioner should apply the product at the deep dermis level. When the product is injected in the subcutaneous layer, there is a risk of vascular compression and/or vascular occlusion (Lee et al, 2018).…”

Development and Usability of a Virtual Reality-Based Filler Injection Training System

“…The filler procedure is performed by injecting a semi-solid material into the body through a thin tube, such as a needle or cannula. The filler’s viscous and elastic properties allow it to effectively function as an implant inside the human body [ 14 , 15 ]. Compared to that with traditional implantation using surgical methods, the filler procedure can be performed with less worry about scars caused by the skin incision, and additional shape correction is possible by removing the filler using an enzyme material injection [ 16 – 18 ].…”