Clinical application of a 3D-printed scaffold in chronic wound treatment: a case series

Sun, Hongfan; Lv, Huayao; Qiu, Fanghui; Sun, Duolun; Gao, Yue; Chen, Ning; Zheng, Yongke; Deng, Kunxue; Yang, Yuqing; Zhang, Haitao; Xu, Tao; Ren, Dongni

doi:10.12968/jowc.2018.27.5.262

Cited by 19 publications

(8 citation statements)

References 10 publications

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“…Similar to PRP, PRF can also be used as a source of GFs to be included in a wound dressing, and once embedded in a gelatin gel, it can promote angiogenesis, granulation tissue formation, and repair of full-thickness skin defects 174 . A recent case study presented by Sun and co-workers showed that the application of a 3D-printed scaffold fabricated with poly(L-lactide acid) (PLLA) and gelatin which are absorbable materials, in combination with PRF, is a highly effective way to repair difficult-to-heal wounds 175 . Interestingly, this kind of system demonstrated ease of application and complete absorption without the need to be removed or changed, two features that increase comfort for patients involved in the study.…”

Section: 41mentioning

confidence: 99%

Wound dressings as growth factor delivery platforms for chronic wound healing

Catanzano

Quaglia

Boateng

2021

Expert Opinion on Drug Delivery

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Introduction: Years of tissue engineering research have clearly demonstrated the potential of integrating growth factors (GFs) into scaffolds for tissue regeneration, a concept that has recently been applied to wound dressings. The old concept of wound dressings that only take a passive role in wound healing has now been overtaken, and advanced dressings which can take an active part in wound healing, are of current research interest. Areas covered:In this review we will focus on the recent strategies for the delivery of GFs to wound sites with an emphasis on the different approaches used to achieve fine tuning over spatial and temporal concentrations to achieve therapeutic efficacy.Expert Opinion: The use of GFs to accelerate wound healing and reduce scar formation is now considered a feasible therapeutic approach in patients with a high risk of infections and complications. The integration of micro-and nanotechnologies into wound dressings could be the key to overcome the inherent instability of GFs and offer adequate control over the release rate. Many investigations have led to encouraging outcomes in various in vitro and in vivo wound models, and it is expected that some of these technologies will satisfy clinical needs and will enter commercialization.

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Section: 41mentioning

confidence: 99%

Wound dressings as growth factor delivery platforms for chronic wound healing

Catanzano

Quaglia

Boateng

2021

Expert Opinion on Drug Delivery

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“…The effectiveness of 3D-printed scaffolds in chronic wounds has not yet been proven, but this seems to be a promising strategy. Sun et al (2018) reported that 3D-printed scaffold membrane alone (n = 1 patient), and 3D-printed scaffold powder mixed with platelet-rich fibrinogen (n = 2) reduced healing time in patients with pressure ulcer and/or DFU (Sun et al, 2018). Another group developed a 3D-printed scaffold that included a drug delivery system based on the body temperature (Pushparaj and Ranganathan, 2017).…”

Section: New Generation Of Dressing and Graftsmentioning

confidence: 99%

Alternative Approaches for the Management of Diabetic Foot Ulcers

et al. 2021

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Diabetic foot ulcers (DFU) represent a growing public health problem. The emergence of multidrug-resistant (MDR) bacteria is a complication due to the difficulties in distinguishing between infection and colonization in DFU. Another problem lies in biofilm formation on the skin surface of DFU. Biofilm is an important pathophysiology step in DFU and may contribute to healing delays. Both MDR bacteria and biofilm producing microorganism create hostile conditions to antibiotic action that lead to chronicity of the wound, followed by infection and, in the worst scenario, lower limb amputation. In this context, alternative approaches to antibiotics for the management of DFU would be very welcome. In this review, we discuss current knowledge on biofilm in DFU and we focus on some new alternative solutions for the management of these wounds, such as antibiofilm approaches that could prevent the establishment of microbial biofilms and wound chronicity. These innovative therapeutic strategies could replace or complement the classical strategy for the management of DFU to improve the healing process.

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“…The novel ECM structure has shown good regeneration capacity in tissue repair. The biomimetic PLLA membrane has been preliminarily applied in dura mater repair and complex wound healing 9–11 . However, only few bioactive materials finally applied in clinic, especially in urethral reconstruction field.…”

Section: Introductionmentioning

confidence: 99%

“…The biomimetic PLLA membrane has been preliminarily applied in dura mater repair and complex wound healing. 9 , 10 , 11 However, only few bioactive materials finally applied in clinic, especially in urethral reconstruction field. In the present study, we aimed to investigate the preclinical and clinical outcomes of the novel biomimetic PLLA fiber graft in anterior urethral substitutional urethroplasty.…”

Section: Introductionmentioning

confidence: 99%

Anterior substitutional urethroplasty using a biomimetic poly‐l‐lactide nanofiber membrane: Preclinical and clinical outcomes

Song

Deng²,

Yuan

et al. 2022

Bioengineering & Transla Med

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The aim of this study is to investigate the feasibility and efficacy of a novel biomimetic poly‐l‐lactide (PLLA) nanofiber membrane in repairing anterior urethral strictures from both preclinic and clinic. Biomimetic PLLA membrane was fabricated layer by layer according to the structure of human extracellular matrix. Microstructure, tensile strength, and suture retention strength were fully assessed. Before the clinical application, the safety and toxicology test of the biomimetic PLLA membrane was performed in vitro and in experimental animals. The patients underwent urethroplasty used dorsal onlay or lateral onlay technique. Then, they were followed up for 1 month, 3 months, 6 months, and then annually after the surgery. The mechanical experiments showed well property for application. Biomimetic PLLA membrane was safe according to the in vitro and animal studies. Then, a total of 25 patients (mean age 48.96 years) were included in the study from September 2016 to December 2018. After a mean follow‐up of 33.56 months, 20 patients successfully treated with biomimetic PLLA membrane. Five patients (2 bulbar and 3 penile) suffered postoperational urethral stricture recurrence. None of infection or urinary fistula or any other adverse events related to the use of biomimetic PLLA membrane were observed during the follow‐up period for all patients. The preliminary result confirmed the feasibility and efficacy of the biomimetic PLLA membrane as a novel material for anterior urethral repair. The long‐term effects with more patients should be investigated in further studies.

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Clinical application of a 3D-printed scaffold in chronic wound treatment: a case series

Abstract: This study demonstrated that 3D-printed scaffold was convenient to use, have the potential to improve wound healing rates, and provided a safe and effective way for treating chronic wounds.

Cited by 19 publications

References 10 publications

Wound dressings as growth factor delivery platforms for chronic wound healing

Wound dressings as growth factor delivery platforms for chronic wound healing

Alternative Approaches for the Management of Diabetic Foot Ulcers

Anterior substitutional urethroplasty using a biomimetic poly‐l‐lactide nanofiber membrane: Preclinical and clinical outcomes

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