Clinical Application and Progress of Fecal Microbiota Transplantation in Liver Diseases: A Review

Gu, Xinpei; Qin, Lu; Zhang, Chengcheng; Tang, Zhewei; Chu, Liuxi

doi:10.1055/s-0041-1732319

Cited by 12 publications

(8 citation statements)

References 94 publications

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“…FMT has therapeutic effects on various liver diseases ( Gu et al, 2021b ), such as viral hepatitis (grade 3), liver cirrhosis (grade 6), and other liver diseases (grade 5). In addition, there is an altered microbial composition in liver transplantation patients (grade 4) and a distinct signature of microbiota associated with the perioperative period ( Lai et al, 2022 ), so FMT may be an intervention strategy to improve transplant outcomes.…”

Section: Discussionmentioning

confidence: 99%

Global research trends and hotspots of fecal microbiota transplantation: A bibliometric and visualization study

et al. 2022

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IntroductionFecal microbiota transplantation (FMT) has gained considerable attention in a variety of clinical research areas, and an increasing number of articles are being published. It is very critical to reveal the global status, future research trends, and hotspots in the FMT research and application.MethodsWe searched the Web of Science Core Collection up to May 10, 2022, and only articles and review articles about FMT were included finally. CiteSpace 5.8.R3, VOSviewer 1.6.18, Scimago Graphica and Microsoft Office Excel 2019 were used for data analysis and visualization. The results included publication characteristics, Co-authorships analysis, Co-cited analysis, Co-occurrence analysis, and burst analysis.ResultsEleven thousand nine hundred seventy-two records were used for the analysis and visualization finally, these records were published between 1980 and 2022, and the publication about FMT is increasing year by year. Co-authorship analysis shown that the USA played a key role in this field. After data analysis and visualization, a total of 57 hotspots about FMT were produced. We summarized these hotspots and classified them into 7 grades according to the number of evidence sources. The evidence sources included top 25 of Web of Science categories, top 30 most Co-cited references, top 10 clusters of references, top 25 references with the strongest citation bursts, top 25 keywords with the most occurrence frequency, major 15 clusters of keywords, top 25 keywords with the strongest citation bursts, and top 35 disease keywords.ConclusionThis bibliometric analysis is expected to provide overall perspective for FMT. FMT has gained increasing attention and interest, there are many hotspots in this field, which may help researchers to explore new directions for future research.

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Section: Discussionmentioning

confidence: 99%

Global research trends and hotspots of fecal microbiota transplantation: A bibliometric and visualization study

et al. 2022

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“…When we use viruses to treat human genetic diseases, we must not forget that the gut microbiota that lives with us from birth to death ( Van Treuren and Dodd, 2020 ; Gu et al., 2021 ). Gut microorganisms play a key role in maintaining health dysbiosis and induce inflammation and metabolic dysfunctions that are associated with metabolic, GI, and neurological diseases; GI tract cancers; and atherosclerotic cardiovascular diseases ( Zununi Vahed et al., 2018 ; Yu et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Adeno-associated virus vector intraperitoneal injection induces colonic mucosa and submucosa transduction and alters the diversity and composition of the faecal microbiota in rats

Lian

Bai

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundViral vector technology, especially recombinant adeno-associated virus vector (rAAV) technology, has shown great promise in preclinical research for clinical applications. Several studies have confirmed that rAAV can successfully transduce the enteric nervous system (ENS), and rAAV gene therapy has been approved by the Food and Drug Administration (FDA) for the treatment of the early childhood blindness disease Leber congenital amaurosis and spinal muscular atrophy (SMA). However, until now, it has not been possible to determine the effect of AAV9 on intestinal microbiota. MethodsWe examined the efficiency of AAV9-mediated ascending colon, transverse colon and descending colon transduction through intraperitoneal (IP) injection, performed 16S rRNA gene amplicon sequencing and analysed specific faecal microbial signatures following AAV9 IP injection via bioinformatics methods in Sprague–Dawley (SD) rats. ResultsOur results showed (1) efficient transduction of the mucosa and submucosa of the ascending, transverse, and descending colon following AAV9 IP injection; (2) a decreased alpha diversity and an altered overall microbial composition following AAV9 IP injection; (3) significant enrichments in a total of 5 phyla, 10 classes, 13 orders, 15 families, 29 genera, and 230 OTUs following AAV9 IP injection; and (4) AAV9 can significantly upregulate the relative abundance of anaerobic microbiota which is one of the seven high-level phenotypes that BugBase could predict.ConclusionIn summary, these data show that IP injection of AAV9 can successfully induce the transduction of the colonic mucosa and submucosa and alter the diversity and composition of the faecal microbiota in rats.

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“…90 FMT has also become a potential therapy for the treatment of NAFLD. 91 Craven et al 92 reported that endoscopic FMT to the distal duodenum in 21 patients with NAFLD resulted in improved small intestine permeability but no significant changes in insulin resistance and hepatic proton density fat fraction. 92 Probiotics are live micro-organisms that improve the microbiota balance in the intestinal tract.…”

Section: Role Of the Intestinal Microbial Barrier In Nafld Developmentmentioning

confidence: 99%

Intestinal Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Liu¹,

Yin²,

Gao³

et al. 2022

J Clin Transl Hepatol

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The mechanisms involved in NAFLD onset are complicated and multifactorial. Recent literature has indicated that altered intestinal barrier function is related to the occurrence and progression of liver disease. The intestinal barrier is important for absorbing nutrients and electrolytes and for defending against toxins and antigens in the enteric environment. Major mechanisms by which the intestinal barrier influences the development of NAFLD involve the altered epithelial layer, decreased intracellular junction integrity, and increased intestinal barrier permeability. Increased intestinal permeability leads to luminal dysbiosis and allows the translocation of pathogenic bacteria and metabolites into the liver, inducing inflammation, immune response, and hepatocyte injury in NAFLD. Although research has been directed to NAFLD in recent decades, the pathophysiological changes in NAFLD initiation and progression are still not completely understood, and the therapeutic targets remain limited. A deeper understanding on the correlation between NAFLD pathogenesis and intestinal barrier regulation must be attained. Therefore, in this review, the components of the intestinal barrier and their respective functions and disruptions during the progression of NAFLD are discussed.

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Clinical Application and Progress of Fecal Microbiota Transplantation in Liver Diseases: A Review

Cited by 12 publications

References 94 publications

Global research trends and hotspots of fecal microbiota transplantation: A bibliometric and visualization study

Global research trends and hotspots of fecal microbiota transplantation: A bibliometric and visualization study

Adeno-associated virus vector intraperitoneal injection induces colonic mucosa and submucosa transduction and alters the diversity and composition of the faecal microbiota in rats

Intestinal Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease

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