Clinical and xeroradiographic lymphangiography studies of acute and chronic<i>Brugia pahangi</i>infections in dogs

Snowden, Karen F.; Hammerberg, Bruce; Smallwood, James E.

doi:10.1080/00034983.1986.11812005

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…The prompt development of lymphocyte responses and of antibody panels during early primary infection in animals is readily demonstrable, but the histological correlates of these early events are elusive: thus, in the Brugia-iniected canine, early tissue reactions to irradiated L-3 forms have been difficult to locate (Ah, McCall & Thompson, 1974). In dogs or cats, weeks may elapse between Brugia inoculation and the onset of regional lymphadenopathy (Snowden, Hammerberg & Smallwood, 1986). Clearly, there is a need for a method by which invasive filarial larvae can be isotope-tagged and traced in the manner already achieved for schistosomula (Georgi, 1982).…”

Section: Immunoregulation Of Host Inflammatory Responsesmentioning

confidence: 99%

The Wellcome Trust Lecture: Inflammatory responses to filarial connective tissue parasites

Lichtenberg

1987

Parasitology

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SUMMARYThe inflammatory responses to lymphatic filariae and to Onchocerca volvulus are reviewed with particular attention to (1) evolutionary biology; (2) inflammatory host spectrum; (3) non-specific components; (4) immunoregulation; (5) immune evasion versus immunomodulation; (6) chronic tissue damage and scarring and (7) disease models. Basic principles of pathogenesis are emphasized, comparisons drawn with schistosome infection, and critical items of missing information are highlighted.

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Section: Immunoregulation Of Host Inflammatory Responsesmentioning

confidence: 99%

The Wellcome Trust Lecture: Inflammatory responses to filarial connective tissue parasites

Lichtenberg

1987

Parasitology

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The lymphatic pathology of chronic Brugia pahangi infection in the dog

Snowden

Hammerberg

1989

Transactions of the Royal Society of Tropical Medicine and Hygi

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The dog infected with Brugia pahangi is an excellent model for studying the clinical and immunological pathogenesis of lymphatic filarial infection and disease. Dogs demonstrated a range of clinical changes including varying levels of microfilaraemia, episodic lymphadenopathy, lymphangitis, and limb oedema similar to the clinical spectrum reported in man. Histologically, tissues from parasite-infected dogs were characterized by fibrosis of the lymph nodes and their afferent and efferent lymphatic ducts in the infected limbs. Some nodes were atrophied while others were characterized by reactive hyperplasia. Duct walls of some afferent lymphatics were thickened with a mononuclear inflammatory infiltrate. Parasite antigen deposition was detected in the subcapsular sinuses and middle of germinal centres of infected popliteal lymph nodes, using an immunohistochemical technique.

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