Clinical and virological features of an aseptic meningitis outbreak in North-Eastern France, 2005

Molecular characterisation of enteroviruses and clinical findings from a cluster of paediatric viral meningitis cases in Tshwane, South Africa 2010–2011

“…Previously reported outbreaks of enteroviral meningitis in children were characterised by the triad of fever, nausea and vomiting [22,24] which was consistent with the findings of this study. In the infant group the findings of fever and irritability also correlated with previous studies [24,36] and vomiting was a common symptom in both the infants (5/8; 63%) and older children (15/20; 75%).…”

“…A single strain of CV-B5 was detected while two strains could not be typed. The predominance of echoviruses in this study was not an unusual finding as in recent years echoviruses have been implicated in numerous outbreaks of aseptic meningitis worldwide [18][19][20][21][22][23][24][25], including SA [10], with E-30, and to a lesser extent E-6 and E-9,being the most frequent EV serotypes identified in outbreaks, including Brazil [20], France [22], Greece [26], India [19], Italy [27,28], Kuwait [23] and Panama [25], and E-4 considered to be a "rare" serotype [21]. The occurrence of E-4 however appears to be a localized rather than global phenomenon as E-4 has been identified as the predominant serotype in outbreaks of aseptic meningitis in Australia [24], Argentina [29], India [19], Italy [27], and in a travel-associated outbreak imported from India to Italy [28].…”

“…In contrast to an E-4-associated outbreak of aseptic meningitis reported in Australia where a significant number of infants presented with diarrhoea (57%) and a rash (22%) [24], there were no dermatological symptoms or diarrhoea in this infant group. The clinical course of all the patients was without sequelae which is not always the case as a fatal case of HEV-related leukoencephalitis in an 18-month old infant was noted in an outbreak in North-Eastern France [22].…”

Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

“…Enteroviruses detected by molecular biology RT-PCR or Real Time PCR or cellular culture analysis show an incidence varying from 10 to 46% 9,12,15,17,19 . Herpesviruses, HHV6, VZV, and a mixed infection by HHV6/EV, were detected in a lower proportion [20][21][22] . In the present study in addition to enterovirus, positive samples for HSV (10%), EBV (3%) and HHV6 (3%) were observed.…”

Rapid Virological Diagnosis of Central Nervous System Infections by Use of a Multiplex Reverse Transcription-PCR DNA Microarray

“…They are responsible for encephalitis and aseptic meningitis (3,5,35). Encephalitis is a rare but one of the most devastating neurological disorders.…”