Clinical and therapeutic aspects of extrapulmonary small cell carcinoma

Walenkamp, Annemiek; Sonke, Gabe S.; Sleijfer, Dirk

doi:10.1016/j.ctrv.2008.10.007

Cited by 174 publications

(218 citation statements)

References 105 publications

Supporting

Mentioning

196

Contrasting

Unclassified

Order By: Relevance

“…As with other epsccs, gu scc has many features in common with small-cell lung carcinoma (sclc), including aggressive behaviour (as manifested by the occurrence of metastases early in the course of the disease) and frequent but short-lasting responses to chemotherapy, except in limited-stage (ls) disease [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

et al. 2013

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In these cases, therapeutic radiotherapy and chemotherapy are advocated (16). The chemotherapeutic regimen for small cell carcinoma of pulmonary origin, which typically includes cisplatin and etoposide, has been used for the treatment of extrapulmonary lesions (2,3,16). The current case was considered to be operable as the patient presented with a single localized gingival lesion.…”

Section: Discussionmentioning

confidence: 99%

“…However, numerous patients exhibit disseminated disease at the time of diagnosis, thus, undergoing radical surgery is not feasible. In these cases, therapeutic radiotherapy and chemotherapy are advocated (16). The chemotherapeutic regimen for small cell carcinoma of pulmonary origin, which typically includes cisplatin and etoposide, has been used for the treatment of extrapulmonary lesions (2,3,16).…”

Section: Discussionmentioning

confidence: 99%

“…A thorough clinical evaluation of the patient is necessary to exclude the possibility of a metastatic SNEC (3,12). Although some differences may exist in the clinical behavior of tumors arising from different subsites, in general, SNEC of the head and neck have a tendency for aggressive local invasion and a strong propensity for both regional and distant metastasis (3,16). Treatment may include surgical resection, radiotherapy, chemotherapy, or some combination of these modalities (3,16).…”

Section: Introductionmentioning

confidence: 99%

“…Treatment may include surgical resection, radiotherapy, chemotherapy, or some combination of these modalities (3,16). The overall prognosis of head and neck SNEC is poor (3,9,16).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature

et al. 2015

View full text Add to dashboard Cite

Abstract. Small cell neuroendocrine carcinoma (SNEC) of the oral cavity is a rare and distinctive tumor with aggressive clinical behavior. Thus far, only a small number of cases have been reported and no definitive standard treatment strategy has been determined. The current study reports a case of oral SNEC arising in the lower gingiva in a 73-year-old male. Computed tomography displayed a relatively well-defined mass measuring 2.8x2x1.4 cm in size. The mass was located in the buccal side of the right mandibular posterior gingiva and exhibited no bony involvement. Histopathological examination revealed a proliferation of small cells with ovoid-to spindle-shaped nuclei, fine granular chromatin, inconspicuous nucleoli, scant cytoplasm and high mitotic activity. Immunohistochemically, the tumor cells were positive for cytokeratin AE1/AE3, chromogranin A, synaptophysin and neuron-specific enolase. Surgical resection and radical neck dissection were performed prior to the administration of adjuvant chemotherapy with a combination of cisplatin and etoposide. No evidence of local recurrence or metastasis was observed at 14 months post-surgery.

show abstract

New-Onset Nasal Obstruction and Epistaxis of the Left Side of the Nose

Lin

et al. 2014

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

A woman in her 50s presented to our otolaryngology clinic with a 3-month history of persistent nasal obstruction of and occasional epistaxis from the left side of her nose. She denied having symptoms associated with aural or cranial nerve involvement. However, a nontender, firm, 3 × 4-cm mass fixed over the upper left side of her neck was detected. The patient was a nonsmoker, and her medical history was not remarkable. The flexible nasopharyngoscopy revealed an unclearly delineated fleshy mass obliterated the left side of the posterior choana (Video 1 and Video 2). Axial T1-weighted gadolinium-enhanced fat-suppressed magnetic resonance image revealed an expansile tumor originating from the posterolateral recess of the nasopharynx, with direct extension into the left sinonasal cavity (Figure, A). The patient then underwent an immediate biopsy. The histopathologic findings revealed an image consisting of nests of small round to oval cells with scant cytoplasm, finely dispersed chromatin, nuclear molding, and inconspicuous nucleoli (Figure, B). Prominent mitotic activity and necrosis, cellular fragility with crushed artifact, and formation of pseudorosettes were readily identifiable. Use of immunohistochemical staining showed these cells to be positive for neural cell-adhesion molecule CD56 (Figure, C), with a dot-like staining pattern for pankeratin marker (clone: AE1/AE3) ( Figure, D), but negative for thyroid transcription factor-1 (TTF-1), synaptophysin, chromogranin A, neuron-specific enolase, cytokeratin 20, CD99, and leukocyte common antigen. These cells also showed strong cytoplasmic expression of p16 but were negative for human papillomavirus (HPV) by in situ hybridization. Subsequent positron emission tomographic-computed tomographic scanning revealed no evidence of distant metastasis.

show abstract

Clinical and therapeutic aspects of extrapulmonary small cell carcinoma

Cited by 174 publications

References 105 publications

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature

New-Onset Nasal Obstruction and Epistaxis of the Left Side of the Nose

Contact Info

Product

Resources

About