Clinical and sociodemographic factors that affect the quality of life of survivors of head and neck cancer

Bonzanini, Laura Izabel Lampert; Soldera, Eloisa Barbieri; Ortigara, Gabriela Barbieri; Schulz, Riéli Elis; Antoniazzi, Raquel Pippi; Ardenghi, Thiago Machado; Ferrazzo, Kívia Linhares

doi:10.1007/s00520-019-05008-4

Cited by 19 publications

(23 citation statements)

References 39 publications

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“…In spite of the strides which have been made in multimodal therapy, the low survival rates have not significantly improved over the last decades ( 1 , 2 ). Additionally, most patients with OSCC may be affected by several morbidities, including severe functional and cosmetic defects, mucositis, xerostomia and osteoradionecrosis, which impair the patients’ quality of life ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population

Jm¹,

Fs²,

Santos‐Silva³

et al. 2021

Med Oral

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Background Among the oral potentially malignant disorders, leukoplakia stands out as the most prevalent. The purpose of this study was to analyse the clinical-pathological features of oral leukoplakia in groups of patients from three major pathology centers in two different regions of Brazil, in order to determine which factors would be associated to the clinical risk of malignant transformation. Material and Methods A total of 148 patients was analyzed, and data regarding gender, age, site, classification of the clinical subtype, harmful habits such as use of tobacco and alcohol, time of evolution and presence of dysplasia were collected. The association between risk factors and malignant transformation was investigated using the chi-square test and Fischer's exact test for correlation of variables. A significance level of 5% ( p ≤0.05) was used. Results The mean age of the patients was 60 years, and 56% were female. Most of the lesions (34,5%) were located in the lateral and ventral regions of the tongue. Of the 148 patients, ninety had clinical follow-up. Malignant transformation occurred in 13 patients (8.8%), with an average of 44 months of follow up. Conclusions Non-smoker, nonhomogeneous clinical presentation, location at the tongue, and the presence of high degree of dysplasia were statistically relevant factors associated with a higher risk of transformation transformation. Key words: Potentially malignant disorders, leukoplakia, malignant transformation, squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population

Jm¹,

Fs²,

Santos‐Silva³

et al. 2021

Med Oral

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“…These include dysphagia (swallowing difficulties), xerostomia (dry mouth), dysgeusia (taste disturbances), and trismus (reduced mouth opening) [8]. The negative effects of eating problems on quality of life (QOL) and everyday life in patients treated for HNC have been documented in quantitative [8][9][10][11][12][13] and qualitative [5,[14][15][16][17][18][19] studies. Based on existing studies [4-7, 18, 20, 21] it is suggested that appropriate rehabilitation services can strengthen the patient's ability to cope with eating problems and thereby reduce the negative consequences.…”

Section: Introductionmentioning

confidence: 99%

Rationale and design of a randomised controlled trial investigating the effect of multidisciplinary nutritional rehabilitation for patients treated for head and neck cancer (the NUTRI-HAB trial)

Kristensen

Wessel²,

Beck

et al. 2020

Nutr J

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Background: Eating problems frequently affect quality of life and physical, psychological and social function in patients treated for head and neck cancer (HNC). Residential rehabilitation programmes may ameliorate these adverse effects but are not indicated for all individuals. Systematic assessment of rehabilitation needs may optimise the use of resources while ensuring referral to rehabilitation for those in need. Yet, evidence lacks on which nutrition screening and assessment tools to use. The trial objectives are: 1) To test the effect of a multidisciplinary residential nutritional rehabilitation programme compared to standard care on the primary outcome body weight and secondary outcomes health-related quality of life, physical function and symptoms of anxiety and depression in patients curatively treated for HNC and 2) To test for correlations between participants' development in outcome scores during their participation in the programme and their baseline scores in Nutritional Risk Screening 2002 (NRS 2002), the Scored Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF), and M. D. Anderson Dysphagia Inventory (MDADI) and to assess sensitivity, specificity and predictive values of the three tools in relation to a clinically relevant improvement in outcome scores.

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“…Patient perceptions in outcome may vary from the provider's perspective and from radiologic or video assessments of functional results. Validated questionnaires such as the UW‐QOL are an increasingly utilized method aimed at capturing patient‐reported perceptions in outcome 17–20 . Particularly in localized early‐stage disease, in which 5‐year survival can be expected to be quite good following surgical resection alone, patient‐reported perceptions of QOL are important outcomes 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Validated questionnaires such as the UW-QOL are an increasingly utilized method aimed at capturing patient-reported perceptions in outcome. [17][18][19][20] Particularly in localized early-stage disease, in which 5-year survival can be expected to be quite good following surgical resection alone, patient-reported perceptions of QOL are important outcomes. 1 We think the data provided in this study are informative and relevant.…”

Section: Discussionmentioning

confidence: 99%

Patient‐Reported Quality of Life After Resection With Primary Closure for Oral Tongue Carcinoma

et al. 2020

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Objectives/Hypothesis For early‐stage oral tongue carcinoma and carcinoma in situ (ESOTCCIS), we evaluated patient‐reported quality‐of‐life (QOL) outcomes following resection with primary closure (R‐PC). Study Design Retrospective review at an academic cancer center. Methods Thirty‐nine ESOTCCIS patients (Tis, T1, T2) who underwent R‐PC without radiation completed the University of Washington Quality of Life Questionnaire Version 4 (UW‐QOL) at least 6 months since R‐PC (mean = 2.39 years; range = 0.5–6.7 years). We compared UW‐QOL scores for pain, swallowing, chewing, speech, and taste to established normative population scores. Multivariable regression analysis evaluated factors associated with QOL impairment. Results ESOTCCIS patients who underwent R‐PC in comparison to the normative population reported significantly worse mean speech (87.7 vs. 98, P < .001) and taste (85.6 vs. 95, P = .002) scores and no significant differences in mean pain (91.7 vs. 86, P = .96), swallowing (100 vs. 98, P = .98), chewing (97.4 vs. 94, P = .98) scores. For speech and taste, 59% (23/39) reported no postoperative change from baseline, whereas 41% (16/39) and 35.9% (14/39) reported mild impairment, respectively. Overall, postoperative QOL was reported as good, very good, or outstanding by 87.2% (34/39). Higher American Society of Anesthesiologists class, cT1 compared to CIS, and ventral tongue involvement were independently associated with worse speech. Age < 60 years was independently associated with worse taste. Conclusions ESOTCCIS patients who undergo R‐PC without radiation can expect long‐term swallowing, chewing, and pain to be in the normative range. Although a majority of patients can expect to achieve normative speech and taste outcomes, R‐PC carries the risks of mild speech and/or taste impairments. Level of Evidence 4 Laryngoscope, 131:312–318, 2021

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Clinical and sociodemographic factors that affect the quality of life of survivors of head and neck cancer

Cited by 19 publications

References 39 publications

Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population

Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population

Rationale and design of a randomised controlled trial investigating the effect of multidisciplinary nutritional rehabilitation for patients treated for head and neck cancer (the NUTRI-HAB trial)

Patient‐Reported Quality of Life After Resection With Primary Closure for Oral Tongue Carcinoma

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