Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Lusambo, Nadine Nsiangani; Kaimbo, D. Kaimbo Wa; Ngoyi, Dieudonné Mumba; Ngoy, Janvier Kilangalanga; Bambi, Marie-Thérèse Ngoyi; Mutombo, Théodore Kadima; Makela, Guy Kintoki; Nzamokili, Lady Ngandowe; de-la-Torre, Alejandra

doi:10.1080/09273948.2022.2140297

Cited by 2 publications

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“…Among the 96 cases of toxoplasmosis, 24 patients (25%) had cicatricial OT. Other clinical characteristics of patients with OT have been previously described 20…”

Section: Resultsmentioning

confidence: 99%

Risk factors for ocular toxoplasmosis among uveitis patients in Kinshasa, DR Congo

et al. 2023

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ObjectiveTo identify the risk factors associated with ocular toxoplasmosis (OT) in a cohort of Congolese patients with uveitis.Methods and analysisA cross-sectional study was conducted between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa. Patients with a diagnosis of uveitis were enrolled in the study. Each patient underwent an interview, an ophthalmological examination and serology testing. Logistic regression was performed to identify risk factors for OT.Results212 patients were included in the study with a mean age at presentation of 42.1±15.9 years (limits: 8–74 years) and a sex ratio of 1.1:1. OT concerned 96 patients (45.3%). The age of the patients below 60 years (p=0.001, OR=9.75 CI 95% 2.51 to37.80)), the consumption of cat meat (p=0.01, OR=2.65 CI 95% 1.18 to 5.96)) and undercooked meat (p=0.044, OR=2.30 CI 95% 1.02 to 5.21)) and living in rural area (p=0.021, OR=11.4 (CI 95% 1.45 to 89.84])) were identified as risk factors for OT.ConclusionOT affects more young people. It is associated with dietary habits. Informing and educating the population is necessary to avoid infection.

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“…Among the 96 cases of toxoplasmosis, 24 patients (25%) had cicatricial OT. Other clinical characteristics of patients with OT have been previously described 20…”

Section: Resultsmentioning

confidence: 99%

Risk factors for ocular toxoplasmosis among uveitis patients in Kinshasa, DR Congo

et al. 2023

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“…In Africa, data on genetic diversity of Toxoplasma gondii and clinical forms of toxoplasmosis are limited ( Mercier et al., 2010 ; Galal et al., 2018 ; Galal et al., 2019a ; Galal et al., 2019b ). However, in West and Central Africa, it has been shown that ocular toxoplasmosis can be a significant health problem ( Abu et al., 2016 ; Nsiangani Lusambo et al., 2023 ). In addition, recent studies in France have described cases of severe toxoplasmosis imported from tropical Africa in immunocompetent patients and associated in some cases with strains belonging to the Africa 1 lineage ( Beltrame et al., 2016 ; Gachet et al., 2018 ; Leroy et al., 2019 ; Artiaga et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

First detection of Toxoplasma gondii Africa 4 lineage in a population of carnivores from South Africa

Račka,

Bártová,

Hamidović

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionThere have only been a few molecular studies conducted on the detection of T. gondii in tissues of carnivores in South Africa, with no data on the genetic diversity of this parasite. That is why the aim of this study was to detect and genotype T. gondii DNA in tissues of selected wild and domestic carnivores in South Africa.MethodsSamples were collected from 80 animals of 20 species (mainly road-killed) in the four provinces of Limpopo (n=57), Mpumalanga (n=21), Gauteng (n=1) and Free State (n=1) during the period 2014–2018. Samples of brain (n=31), heart (n=4), liver (n=40), spleen (n=2) and lung (n=3) were used to detect T. gondii by real-time PCR targeting a 529 bp repeating fragment of T. gondii DNA. Samples that were positive in real-time PCR were genotyped using 15 microsatellite markers.ResultsT. gondii DNA was detected in 4 (5 %) samples: in the brain from a Black-backed Jackal (Canis mesomelas), in the liver from a African Wildcat (Felis silvestris lybica) and in the liver and heart of two Rusty-spotted Genets (Genetta maculata) respectively. The DNA sample from Black-backed Jackal was genotyped and characterized as belonging to the type Africa 4 lineage (equivalent to RFLP genotype ToxoDB#20), that is a widespread lineage in Africa.DiscussionThis is the first genetic characterization of T. gondii isolated from a wild carnivore on the African continent and the first report of T. gondii in Black-backed Jackal. The Africa 4 lineage was also confirmed in the region of Southern Africa for the first time.

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Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Cited by 2 publications

References 40 publications

Risk factors for ocular toxoplasmosis among uveitis patients in Kinshasa, DR Congo

Risk factors for ocular toxoplasmosis among uveitis patients in Kinshasa, DR Congo

First detection of Toxoplasma gondii Africa 4 lineage in a population of carnivores from South Africa

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