Clinical and radiological manifestations of 206 patients with pulmonary hydatidosis over a ten-year period

Darwish, Bassam

doi:10.1016/j.pcrj.2006.05.006

Cited by 20 publications

(18 citation statements)

References 10 publications

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“…Also, there were multiple lung cysts in 38.46% of cases and bilateral cysts in 21.53% of cases. These results are similar to those shown in previous studies where pulmonary hydatid cysts were solitary in most cases (∼75%),31 with a slight predilection for the right lung (∼60%)14 and frequently located in the lower lobes (∼60%),3 and a minority of cases had multiple pulmonary cysts (∼30%) or bilateral cysts (∼20%) 3,32. Interestingly, the number of cysts was not correlated to the chances of being seropositive on EITB, as previously shown with other less specific assays 17,18,23,27.…”

Section: Discussionsupporting

confidence: 93%

Absence of Brain Involvement and Factors Related to Positive Serology in a Prospective Series of 61 Cases with Pulmonary Hydatid Disease

Santivañez

Sotomayor

Vasquez

et al. 2008

The American Journal of Tropical Medicine and Hygiene

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A prospective series of 65 patients with surgically confirmed lung cystic hydatid disease was evaluated in terms of their radiologic characteristics, serologic response, and presence of cysts in other organs. Cysts were mostly single and located in lower lung lobes. Liver compromise was found in 34% of the patients. Despite a systematic search, no patient showed brain cysts in this series. Twelve patients had previous hydatid disease: six in the liver and eight in the lung (two had involvement of both organs in the past). Serology using bovine cyst fluid in an immunoblot assay was 85% sensitive. Serologic response was not associated with number or cyst or compromise of other organs but was clearly associated to the presence of at least one complicated cyst. Cyst status in terms of complications should be described to allow appropriate assessment of serologic evaluations.

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Section: Discussionsupporting

confidence: 93%

Absence of Brain Involvement and Factors Related to Positive Serology in a Prospective Series of 61 Cases with Pulmonary Hydatid Disease

Santivañez

Sotomayor

Vasquez

et al. 2008

The American Journal of Tropical Medicine and Hygiene

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“…Community X-ray surveys in Peru have demonstrated a 1.1% to 2% prevalence of pulmonary cases in the general population (11,15), with the majority of them being asymptomatic. The proportions of symptomatic cases vary greatly, from 27% to 59% (7,17). Morbidity of lung CHD is higher than that of liver cases, probably due to rapid growth of cysts in the loose lung tissue and the development of a thinner cystic membrane that makes these cysts more likely to rupture or to host an additional bacterial or fungal infection (2,20).…”

Section: Discussionmentioning

confidence: 99%

Serological Diagnosis of Lung Cystic Hydatid Disease Using the Synthetic p176 Peptide

Santivañez

Arias

Portocarrero

et al. 2012

Clin Vaccine Immunol

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ABSTRACTCystic hydatid disease (CHD) is a worldwide zoonosis caused by the larval stage of the dog tapewormEchinococcus granulosus. Diagnosis is based on imagenological tools (abdominal ultrasound, chest X-rays, or computed tomography [CT] scan). Serological antibody-detecting assays, using diverse native antigens, have been used as a supportive diagnostic tool, but their sensitivities and specificities differ greatly. The use of synthetic peptides as antigens should provide more reliability and allow better assessment and comparison of test formats and case series. The synthetic peptide p176, corresponding to the N-terminal extreme of the subunit of antigen B (AgB8/1), has shown promising performances for diagnosis of CHD. We evaluated the performance of the synthetic peptide p176 for the diagnosis of pulmonary hydatid disease in an enzyme-linked immunosorbent assay (ELISA) format. Sixty-one serum samples from patients with a diagnosis of pulmonary hydatidosis confirmed by surgery and 128 from healthy volunteers were tested. The overall sensitivity and specificity of the p176 ELISA for lung CHD were 78.69% and 96.88%, respectively. On bivariate analysis, positive serum antibody reactions were associated with the presence of complications and with the number of cysts (single/multiple). Only the presence of persistent complications significantly associated with seropositivity on multivariate logistic regression analysis (odds ratio [OR], 9.58; 95% confidence interval [CI], 2.15 to 42.6;P= 0.003). The p176 ELISA performs well for the diagnosis of lung CHD and adds an easily reproducible diagnostic assay to the existing diagnostic tools.

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“…In the case of Syria, current prevalence data regarding human infection are not available and detailed epidemiological studies are required from this country. A single report described more than 20 cases of pulmonary CE undergoing surgery per year in a university hospital in Damascus (Darwish, 2006).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

Global Distribution of Alveolar and Cystic Echinococcosis

Deplazes

Rinaldi

Rojas

et al. 2017

Advances in Parasitology

743

679

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Clinical and radiological manifestations of 206 patients with pulmonary hydatidosis over a ten-year period

Cited by 20 publications

References 10 publications

Absence of Brain Involvement and Factors Related to Positive Serology in a Prospective Series of 61 Cases with Pulmonary Hydatid Disease

Absence of Brain Involvement and Factors Related to Positive Serology in a Prospective Series of 61 Cases with Pulmonary Hydatid Disease

Serological Diagnosis of Lung Cystic Hydatid Disease Using the Synthetic p176 Peptide

Global Distribution of Alveolar and Cystic Echinococcosis

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